Integrase Inhibitors

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Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	N155H
Rx	>=1 INI
IncludeMixtures	No

References	11
Patients	31
Isolates	39

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	Wks	INIMajorDRMs	INIMinorDRMs	OtherMut	Subtype
Malet (2008)	1b	H-SH1-W8	FJ538990	RAL	8	Q148R, N155H		E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
	2a	H3-W24	FJ538978	RAL	24	N155H		E10D, L101I, G106A, K156N, V165I, S195C, V201I, I220V	B
	2b	H5-W18	FJ538982	RAL	17	N155H	G163R	V32I, S39C, M50I, T112I, I113V, T124N, V201I, L234V, S255R	B
	2d	H2-W28	FJ538976	RAL	29	E92Q, N155H		E11D, V31M, V32I, S39C, I72V, L101I, K111R, S119P, I135V, G193E, V201I, T218S	B
	H1	H1-W12	FJ538974	RAL	13	N155H		L2W, K7R, R20K, V31I, L101I, T112V, T124A, T125A, F181L, V201I, K219N, N222K	B
	H6	H6-W20	FJ538984	RAL	20	N155H	T97A, V151I	E11D, V31I, L101I, K111T, I113V, S119T, T124N, T125A, S195C, A196P, A205T, T218S, D232N	B
	HSH2	H-SH2-W12	FJ538993	RAL	16	N155H		S17N, R20K, L28I, S39C, T124A, T125A, V201I, I208L	B
Baldanti (2009)	PV9	PV9	GU350734	RAL	52	N155H		L101I, K127R, G193E, T206S	B
	PV3	PV3	GU350736	RAL	13	G140S, Q148H, N155H		S17N, I72V, T124A, M154I, E170A, V201I	B
	PV6	PV6	GU350737	RAL	26	N155H	E92G	A23V, T124A	B
Garrido (2009)	Pt04	Pt04		RAL		N155H	V151I	E11D, S17T, I72V, E198D, V201I, K211R, D270DA	B
	Pt05	Pt05		RAL		N155H	L74M, V151I	E11D, R20K, L101I, S119P, T122I, T124A, S195T, I203M, Y227F, D253DY, S255N, D256E	B
	Pt06	Pt06		RAL		N155H	G163K	S17N, A38AV, L101I, T112I, T124A, T125V, E157Q, K160Q, K211R, D256E	B
	Pt08	Pt08		RAL		N155H	E138ED	M50IT, L101I, L104I, T124A, A205AS, T206S, I208IL, D256E	B
	Pt09	Pt09		RAL		N155H		E11D, R20K, L28I, S39C, L101I, S119P, T122I, F181L, V201I, Y227F, L234V, D256E	B
Sichtig (2009)	Pt07	5163	FJ183699	RAL	62	N155H	Q146QK	E11D, K14R, A21T, A23V, V88I, I113V, S119P, T124N, T125A, Q177R, T206S	B
	Pt08	5255	FJ183703	RAL	76	N155H	V151VI, G163GR	T112I, T124N, M154I, V201I, D232DN	B
	Pt09	5358	FJ183704	RAL	106	N155H	V151I	K14KR, I72IV, T124A, I162V, E170AT, S195SR, I200L, V201I, I220L, L234I, I251IL	B
	Pt04	4833	FJ183697	RAL	41	N155H	V151VI, G163GR	S17N, V31I, T112V, T124N, T125A, V126L, S230N, D256E	B
		4951	FJ183698	RAL	50	N155H	V151I, G163R	S17N, V31I, T112V, T124N, T125A, V126L, S230N, D256E	B
Wittkop (2009)	7	7_M3	GU358385	RAL	12	N155H		S17N, I72V, L101I, S119G, T122I, T125A, A169S, T218S, I220L, Y227F	B
Hatano (2010)	3	Virus9	GU121685	RAL		N155H	V151I	D6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275V	B
		Virus10	GU121686	RAL		N155H	V151I	D6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275V	B
		Virus11	GU121687	RAL		N155H	V151I	D6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275V	B
		Virus12	GU121688	RAL		N155H	V151I	D6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275V	B
	11	Virus104	GU121780	RAL		G140GS, N155H	A128AT, V151VI	E10DG, E11D, V31I, S119P, T122I, T125A, V126M, G163E, S195C, L234V, D279DN	B
Blanco (2011)	CA4825	CA128619		RAL	21	N155H	G163K	E11D, S24N, V31I, L101I, I113V, S119P, T122I, T124N, T125A, V201I, K211KR	B
	ACM_09BL	ACM_09BL		RAL		N155H		E10D, S119G, T122I, T124N, T125A, M154I, K211R	B
	GCC_10BL	GCC_10BL		RAL		N155H	V151I	A21S, M22I, A23V, S24G, I84V, M154I, V165I, V201I, D232N	B
Brenner (2011)	INT12	INT12_1	HQ207812	RAL		N155H	L74LM, V151I, G163GR	E11D, S24N, V31I, L101I, S119P, T122I, K136Q, V150A, K211R, D286N	B
	INT6	INT6_1	HQ207828	RAL		Y143C, N155H	S230R	S17N, M50I, L101I, T112I, T124N, G163E, A169S, V201I, T206S, I220L, Q221S, D279G	B
	081911.030	081911.030	HQ423437	RAL		N155H	V151I, G163GR	E11D, S24N, L101I, S119P, T206S, D207E, E212A	B
Garrido (2012)	BAA295872	BAA295872	JQ716873	RAL	52	N155H	L74LM	E11D, K14R, K34R, D41N, P90S, L101I, K111KQ, S119SR, K156N, I208L, D256E	B
	BAA295882	BAA295882	JQ716875	RAL	52	E92EQ, N155H	T97TA	K7R, S17N, R20K, L101I, T112V, S119P, T124A, I135V, I220L, D232DN, D253DN	B
	BAA295856	BAA295856	JQ716880	RAL	52	Y143YH, N155H		S17N, E96N, L101I, S119P, T122I, T124A, K156N, V201I, T206S, I208L, Y227F, D253Y, D256E	B
	BAA295902	BAA295902	JQ716896	RAL	52	N155H		S17N, L101I, T112I, V165I, H171L, T206S, D256E	B
Lee (2012)	3508	41205A.8	JQ666926	RAL	30	N155H	V151I	D6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275V	B
Parczewski (2012)	307	307_18	KC409156	RAL	196	N155H		E10D, L101I, T112I, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278G	B
		307_x	KC409158	RAL	201	N155H		E10D, L101I, T112I, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278G	B

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