<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation N155H
Rx >=1 INI
IncludeMixtures No
References 15
Patients 59
Isolates 73
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Malet (2008)1bH-SH1-W8FJ538990RAL8Q148R, N155H E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
 2aH3-W24FJ538978RAL24N155H E10D, L101I, G106A, K156N, V165I, S195C, V201I, I220VB
 2bH5-W18FJ538982RAL17N155HG163RV32I, S39C, M50I, T112I, I113V, T124N, V201I, L234V, S255RB
 2dH2-W28FJ538976RAL29E92Q, N155H E11D, V31M, V32I, S39C, I72V, L101I, K111R, S119P, I135V, G193E, V201I, T218SB
 H1H1-W12FJ538974RAL13N155H L2W, K7R, R20K, V31I, L101I, T112V, T124A, T125A, F181L, V201I, K219N, N222KB
 H6H6-W20FJ538984RAL20N155HT97A, V151IE11D, V31I, L101I, K111T, I113V, S119T, T124N, T125A, S195C, A196P, A205T, T218S, D232NB
 HSH2H-SH2-W12FJ538993RAL16N155H S17N, R20K, L28I, S39C, T124A, T125A, V201I, I208LB
Baldanti (2009)PV9PV9GU350734RAL52N155H L101I, K127R, G193E, T206SB
 PV3PV3GU350736RAL13G140S, Q148H, N155H S17N, I72V, T124A, M154I, E170A, V201IB
 PV6PV6GU350737RAL26N155HE92GA23V, T124AB
Garrido (2009)Pt04Pt04 RAL N155HV151IE11D, S17T, I72V, E198D, V201I, K211R, D270DAB
 Pt05Pt05 RAL N155HL74M, V151IE11D, R20K, L101I, S119P, T122I, T124A, S195T, I203M, Y227F, D253DY, S255N, D256EB
 Pt06Pt06 RAL N155HG163KS17N, A38AV, L101I, T112I, T124A, T125V, E157Q, K160Q, K211R, D256EB
 Pt08Pt08 RAL N155HE138EDM50IT, L101I, L104I, T124A, A205AS, T206S, I208IL, D256EB
 Pt09Pt09 RAL N155H E11D, R20K, L28I, S39C, L101I, S119P, T122I, F181L, V201I, Y227F, L234V, D256EB
Sichtig (2009)Pt075163FJ183699RAL62N155HQ146QKE11D, K14R, A21T, A23V, V88I, I113V, S119P, T124N, T125A, Q177R, T206SB
 Pt085255FJ183703RAL76N155HV151VI, G163GRT112I, T124N, M154I, V201I, D232DNB
 Pt095358FJ183704RAL106N155HV151IK14KR, I72IV, T124A, I162V, E170AT, S195SR, I200L, V201I, I220L, L234I, I251ILB
 Pt044833FJ183697RAL41N155HV151VI, G163GRS17N, V31I, T112V, T124N, T125A, V126L, S230N, D256EB
  4951FJ183698RAL50N155HV151I, G163RS17N, V31I, T112V, T124N, T125A, V126L, S230N, D256EB
Wittkop (2009)77_M3GU358385RAL12N155H S17N, I72V, L101I, S119G, T122I, T125A, A169S, T218S, I220L, Y227FB
Hatano (2010)3Virus9GU121685RAL N155HV151ID6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275VB
  Virus10GU121686RAL N155HV151ID6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275VB
  Virus11GU121687RAL N155HV151ID6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275VB
  Virus12GU121688RAL N155HV151ID6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275VB
 11Virus104GU121780RAL G140GS, N155HA128AT, V151VIE10DG, E11D, V31I, S119P, T122I, T125A, V126M, G163E, S195C, L234V, D279DNB
Blanco (2011)CA4825CA128619 RAL21N155HG163KE11D, S24N, V31I, L101I, I113V, S119P, T122I, T124N, T125A, V201I, K211KRB
 ACM_09BLACM_09BL RAL N155H E10D, S119G, T122I, T124N, T125A, M154I, K211RB
 GCC_10BLGCC_10BL RAL N155HV151IA21S, M22I, A23V, S24G, I84V, M154I, V165I, V201I, D232NB
Brenner (2011)INT12INT12_1HQ207812RAL N155HL74LM, V151I, G163GRE11D, S24N, V31I, L101I, S119P, T122I, K136Q, V150A, K211R, D286NB
 INT6INT6_1HQ207828RAL Y143C, N155HS230RS17N, M50I, L101I, T112I, T124N, G163E, A169S, V201I, T206S, I220L, Q221S, D279GB
 081911.030081911.030HQ423437RAL N155HV151I, G163GRE11D, S24N, L101I, S119P, T206S, D207E, E212AB
Canducci (2011)Pt8Pt8w12JN163901RAL13Y143R, N155H S17N, A49S, I72V, T124A, M154I, E170A, V201I, G277RB
 Pt9Pt9w4JN163903RAL4N155H A23V, T124AB
Armenia (2012)PT_69PT_69_MO_5JN544100RAL N155HE92EAA8P, D25E, L28I, S39C, L101I, V165I, K215N, Q216HB
  PT_69_MO_7JN544101RAL E92EAPQ, E138EK, N155HV151VIR20RK, D25E, L28I, E35EK, S39C, G47GE, L101I, V165I, K215KN, Q216H, D232DN, D286DNB
 PT_145PT_145_MO_10JN544115RAL N155HE92EA, T97TAE10D, L28I, K34KR, L101I, S119SR, K136NB
 PT_229PT_229_MO_9JN544121RAL Y143C, N155HS230RK7R, S17N, L101I, S119P, T122I, K156N, V165I, V201I, T206S, T218S, K219N, D256E, D278A, V281VMB
  PT_229_MO_11JN544122RAL Y143C, N155HS230RK7R, S17N, E69EQ, L101I, S119P, T122I, K156N, V165I, V201I, T206S, T218S, K219N, N222NK, D256DE, D278A, V281VMB
 PT_141PT_141_MO_6JN544113RAL N155HV151I, G163GRD6T, K7E, E11D, K14R, V31I, M50I, I72IV, I113V, S119SR, T125A, V201I, D256E, V281VMB
 PT_81PT_81_MO_3JN544105RAL N155H H16P, L28I, T112I, S119P, K156N, V201IB
Garrido (2012)BAA295872BAA295872JQ716873RAL52N155HL74LME11D, K14R, K34R, D41N, P90S, L101I, K111KQ, S119SR, K156N, I208L, D256EB
 BAA295882BAA295882JQ716875RAL52E92EQ, N155HT97TAK7R, S17N, R20K, L101I, T112V, S119P, T124A, I135V, I220L, D232DN, D253DNB
 BAA295856BAA295856JQ716880RAL52Y143YH, N155H S17N, E96N, L101I, S119P, T122I, T124A, K156N, V201I, T206S, I208L, Y227F, D253Y, D256EB
 BAA295902BAA295902JQ716896RAL52N155H S17N, L101I, T112I, V165I, H171L, T206S, D256EB
Lee (2012)350841205A.8JQ666926RAL30N155HV151ID6E, E10D, A23S, V31I, L101I, T124A, K156N, V201I, D232N, M275VB
Parczewski (2012)307307_18KC409156RAL196N155H E10D, L101I, T112I, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278GB
  307_xKC409158RAL201N155H E10D, L101I, T112I, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278GB
de Souza Cavalcanti (2014)BRSP332BRSP332 RAL N155HT97A, V151I, G163RS17N, V31I, I72V, S119R, T124A, T125V, K156N, V165I, Q168R, V201I, R224Q, D256E, R269K, V281M, S283GB
 BRSP94BRSP94 RAL N155HT97A, V151ID6E, E10D, A21S, A23V, S39R, M50I, L101I, S119P, T122I, K156R, A169V, S230N, L234I, S283NB
 BRSP73BRSP73 RAL N155H D25E, V31I, M154I, S230NB
 BRSP37BRSP37 RAL N155HT97A, V151IS17N, A21S, D25E, L28I, S39C, L101I, S119R, T218SB
 BRSP24BRSP24 RAL N155HE138D, V151IE10D, A21S, E170AB
 BRSP545BRSP545 RAL E92Q, N155H K14R, Y15H, V32I, S39C, M50I, I73IV, L101I, S119P, T124A, I135V, K136N, E157Q, K160Q, I162V, V201I, L234V, K240RB
 BRSP380BRSP380 RAL N155HE138D, V151IE11D, D25E, L28I, V37I, S39C, M50L, L74I, L101LF, T124A, E157Q, K160T, I203M, I208M, D232N, L234I, D253E, N254GB
 BRSP406BRSP406 RAL N155H S17N, I72V, L101I, S119R, T124A, I135V, K156N, S283GB
 BRSP101BRSP101 RAL N155HV151IS17N, L101I, S119ST, T124TA, K136Q, E157Q, K160T, A169V, L172LI, I208M, D232N, L234I, D253E, D256EB
 BRSP385BRSP385 RAL N155HV151IS24G, S119P, T122I, T124A, T125A, V201I, A205S, S255NB
 BRSP268BRSP268 RAL N155HV151IS17N, L28I, T112I, S119G, T122I, T124N, T125A, E157Q, K160Q, V201IB
 BRSP359BRSP359 RAL N155HV151ID6T, K7E, E10D, V31I, K71KQ, I72V, I84M, A91R, L101I, T112I, V201I, T206S, D279DNB
 BRSP496BRSP496 RAL E92Q, N155HV151IH12Q, K14R, A21S, A23T, V31I, L101I, T124A, I204V, K215N, D279NB
 BRSP95BRSP95 RAL N155HT97A, V151ID6N, K7E, M50I, L101I, S119P, V201I, T206S, I208L, K211R, E212L, D232NB
 BRSP145BRSP145 RAL N155HV151VIS17N, S24D, L28I, S39C, T124N, T125A, V126L, T218S, D278NB
 BRSP705BRSP705 RAL E92Q, N155HV151IE10D, A21SB
 BRSP710BRSP710 RAL Y143C, N155HS230RV31I, L101I, T112I, S119T, T124A, E157Q, K160Q, V201I, C280SB
 BRSP128BRSP128 RAL N155HV151ID3E, S17N, A21S, S24N, I72V, V77A, L101I, I113V, T124A, D232NB
 BRSP273BRSP273 RAL Y143YC, N155HV151IS17N, A21S, V31I, L101I, K103R, T124A, I135V, V201I, T218L, K219Q, L234V, D256E, S283GB
 BRSP231BRSP231 RAL N155HA128T, V151IS17N, L28I, I72V, I208L, L234H, S283GB
Hardy (2014)Pt1INTPt1INT RAL22N155H R20K, V31I, L45I, L101I, I135IV, E157Q, K160Q, V201I, K215N, A265VB
  Pt1INT RAL, DTG69N155HV151IR20K, V31I, L45I, L101I, S119SR, I135V, E157Q, K160Q, V201I, K215NB
  Pt1INT RAL, DTG110E138K, S147G, N155HT97A, V151ID6DN, R20RK, V31I, L45I, L101I, S119R, I135V, E157Q, K160Q, V201I, K215NB
  Pt1INT RAL, DTG157E138K, S147G, N155HT97A, V151IR20K, V31I, L45I, A49P, L101I, S119R, T122TAIV, I135V, E157Q, K160Q, V201I, K215N, L234VB
  Pt1INT RAL, DTG168E138K, S147G, N155HT97A, V151IR20RK, V31I, L45I, A49P, L68LF, L101I, S119R, T122TAIV, I135V, E157Q, K160Q, V201I, K215N, L234VB