<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation M154L
Rx II-naive
IncludeMixtures No
References 39
Patients 104
Isolates 107
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Herring (2001)1052PT1052 None   L101I, T125A, I135V, M154L, K211R, S230NB
Reinke (2001)R104R104AF203330None   E11D, S17T, V37M, I72V, T112V, S119P, T122I, M154L, V165I, V201I, S230NB
Rousseau (2006)Pt2303PS045MB2DQ396398None   E11D, E13D, R20K, A21T, D41G, I72V, K111R, T124A, M154L, V165I, D207G, K211R, T218I, S230NB
Badreddine (2007)J11462SB_J11462DQ375276None   V31VI, I72V, A91S, L101I, T124N, M154L, F181L, V201I, K211R, T218IB
Lataillade (2007)01-3751ML_01-3751EF472761None  F121FSE11D, D25E, V31I, I72V, S119P, T122I, T124A, M154L, V201IB
 02-1435ML_02-1435EF472781None   R20K, A23V, I72V, L101I, T124A, M154L, F181L, V201I, T206S, K219KR, Y227F, E246ED, S255N, D256EB
Brennan (2008)ABB32-96ABB32-96EU618519None   E11D, M50I, I72V, T124A, M154L, E157G, G193D, S195T, K211R, I268L, D270NB
Buzon (2008)Pt34Pt34Y1996EU883889None   D6DE, S24G, D25E, S39C, D41N, I72V, I84IM, L101LI, M154L, V165I, V201IB
  Pt34Y2000EU883890None   S24G, D25E, S39C, D41N, I72V, I84M, L101I, M154LB
  Pt34Y2003EU883891None   S24G, D25E, S39C, D41N, I72V, I84IM, L101LI, T124TA, M154L, V165I, V201VIB
  Pt34Y2005EU883892None   S24G, D25E, S39C, D41N, I72V, I84M, L101I, M154L, V165I, V201IB
Matthews (2008)PS045PS045FJ199626None   E11D, E13D, R20K, A21T, D41G, I72V, K111R, T124A, M154L, V165I, D207G, K211R, T218I, S230NB
Miura (2008)BEC7BEC7EU517862None   S24SG, I72V, K111KT, M154L, V165I, T206SB
 BEC117BEC117EU517864None   E11D, A21T, I72V, T112A, S119P, T124TA, M154L, I208L, Q252QK, I267ITB
 BEC49BEC49EU517874None   E11D, S24N, N27S, I72V, Q95H, M154L, V201I, I220M, N222H, S255R, A265VB
 BEC121BEC121EU517896None   I72V, L101I, M154LB
Brumme (2009)INT_3533INT_3533FJ812984None   I72V, L74I, L101I, S119G, T122I, M154LB
 INT_3577INT_3577FJ813028None   C56CG, A91AS, L101I, S119SG, T122I, T124TA, M154L, V180VA, V201VI, A265AVB
 INT_3584INT_3584FJ813035None   E11D, I72V, S119AGPR, T122TI, T124TN, T125V, M154L, T218TI, I220L, Q221HB
 INT_3662INT_3662FJ813113None   E11D, V32I, I72V, T124S, T125M, V126M, M154L, V201I, T206SB
 INT_3745INT_3745FJ813196None   I72V, P90S, T124TA, M154L, K173R, V201IB
 INT_3782INT_3782FJ813233None   L101I, T124TA, M154L, L234IB
 INT_3786INT_3786FJ813237None   I72V, L101I, M154L, R284RGB
 INT_3800INT_3800FJ813251None   E11D, L28I, S39SC, I72V, T124A, M154L, I200L, V201IB
 INT_3875INT_3875FJ813326None   E11D, I72IV, L101I, T112TA, S119G, T122I, M154L, R187RK, S195T, D256EB
 INT_3906INT_3906FJ813357None   E11ED, I72V, T124S, T125M, V126M, M154L, V201IB
 D3532D3532GQ371819None   I72V, A133AG, M154L, Q164QHB
 F2528F2528GQ371865None   K14R, V31I, I72V, A91S, Q95H, T112I, I113V, S119P, T125A, M154L, V201I, T206S, D256EB
 L8537L8537GQ371996None   D6E, E11D, E13D, V31I, L101LI, T112AV, S119P, T122I, T124TA, M154L, D256EB
 M4526M4526GQ372008None   E11D, K14R, I72V, K103R, S119P, T122I, T124N, T125A, M154L, G189R, S195T, V201I, T218I, R262RKB
 N6522N6522GQ372039None   G70E, I72V, T124A, M154L, G193D, V201I, T206S, Q216H, Y226F, L234I, K266KR, I268L, D270HB
 P4505P4505GQ372084None   K14R, L28I, S39C, I84M, L101I, T124A, M154L, V201I, K240RB
 V0570V0570GQ372200None   E11D, H16HP, Q53QE, I72V, S119P, T122I, T124N, T125A, M154L, G193R, V201I, T206SB
 V5578V5578GQ372210None   I72V, I84M, S119P, M154L, V201I, A205S, T206S, D207E, T218I, D256DEB
 X9501X9501GQ372267None   I72V, K103K*, S119PT, T124N, T125TA, V126L, A133AG, M154L, I217IT, T218SB
 Y1525Y1525GQ372275None   K7R, V31I, I72V, L101I, K111KR, T124TA, I135V, M154L, F181L, T206S, I220MB
Canducci (2009)pt4pt4blEU908759None   D3Q, G70E, L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256EB
Garrido (2009)154INT-154GU217001None   A23V, I72V, M154L, V201I, D279NB
 325INT-325GU217172None   D25E, V31I, S39N, I72V, L101I, I113V, S119P, T124A, K136N, M154L, D253HB
Low (2009)F-15F-15FJ786302None   I72V, T124N, T125A, V126L, M154L, V201I, T206S, C280SB
 G-8G-8FJ786303None   I72V, L101I, S119T, M154L, V201I, S283GB
 ahi96ahi96_03FJ786364None   S17N, I72V, T124N, T125A, I135V, M154L, V201IB
 mdr3mdr3FJ786386None   V31I, M50L, I72V, M154L, H171Q, V201I, T218S, S283GB
Passaes (2009)BR.RJ.FT46BR.RJ.FT46HM026767None   K7R, E11D, V31I, I72V, L101V, M154L, T206SB
Sichtig (2009)21-E21-EFJ183544None   E11D, K14R, A21T, V31I, V32I, I72V, I84MV, L101I, T122TI, T124A, T125A, I135V, M154L, V165I, S230NB
Wang (2009)L8124PL8124PFJ469741None   I72V, L101I, T112I, S119P, T122I, T124N, T125A, M154L, D167E, V201I, T206S, I208M, D256EB
 PRLS28PRLS28FJ469766None   D25E, I72V, T124N, M154LB
Arruda (2010)EI018EI018GQ864173None   E10D, K14T, L28I, S39C, I72V, I84M, E96A, I113L, T122I, T124N, N144H, M154L, K211R, D253EB
Rangel (2010)HIV202bHIV202bGU797510None   I72V, I113V, T124N, M154L, V201I, T206S, S230SN, D256EB
 HIV249pHIV249pGU797528None   I72V, A91S, L101I, S119P, M154L, V201I, T206S, T210TI, K211KR, D256EB
 HIV270bHIV270bGU797543None   A23V, L101I, K103KR, M154L, T218S, D253EB
 HIV270pHIV270pGU797544None   A23V, I72IV, L101I, K111KR, M154L, Y194C, I204IK, T218S, D253EB
Blanco (2011)CA14192CA124188 None   T112V, M154L, V201I, V259VIB
Brenner (2011)51PHI51PHIHQ207725None  L74ME11D, M50I, L101V, M154L, K211Q, D278NB
 67996799HQ207740None   E11D, D25DE, V31I, I72V, T112A, T124N, T125I, M154L, D256E, S283G, D288GB
 68526852HQ207744None   E11D, V31I, I72V, T112A, T124N, T125I, M154L, V165H, D256E, S283G, D288GB
 69586958HQ207745None   E11D, D25DE, V31I, I72V, T112A, T124N, T125I, M154L, D256E, S283G, D288GB
 96049604HQ207797None   V31I, I72V, T112A, T124N, T125M, M154L, S230N, D256E, S283GB
Canducci (2011)Pt2Pt2blJN163880None   L101I, S119R, T124N, T125A, M154L, V165I, D256E, G277CB
Kousiappa (2011)CY190CY190JF683743None   E11D, S24N, V31I, L45V, I72V, T112A, S119P, T124N, M154L, K211RB
 CY194CY194JF683746None   E11D, S24N, V31I, L45V, I72V, T112A, S119P, T124N, M154L, A196T, V201I, K211RB
 CY268CY268JF683809None   E11D, S24N, V31I, L45V, I72V, T93N, T112A, S119P, T124N, M154L, N254KB
Rolland (2011)2495consensus_2495JF320054None   E11D, A21T, M22I, A23V, L28M, V32I, I72V, I84M, T112A, S119P, T124A, T125A, M154LB
 2000consensus_2000JF320276None   S17N, V31I, I72V, L74V, T112A, T125A, V126M, M154L, V201VI, K211KRB
 0388consensus_0388JF320315None   E10D, L45V, I72V, L101I, K103R, S119P, T122I, M154L, K211RB
 0176consensus_0176JF320363None   I72V, P90S, T124N, T125V, M154L, K173R, V201IB
 1709consensus_1709JF320460None   V31VI, V32VI, L101I, T125TA, M154L, V165I, V201I, V281MB
Brockman (2012)AEHIV30AEHIV30JQ080114None   R20K, I72V, K111R, M154L, T210I, K211R, D256EB
Iamarino (2012)BF.BR.0441BF.BR.0441JN234034None   F100Y, L101I, T125A, M154L, L234V, D256E, S283GB
Molina (2012)40204020_1 None   V31I, P90PS, T112AV, T124A, M154L, K211R, T218S, S230N, S283GB
 32693269_1 None   S39C, M50I, L101I, S119P, M154L, K173KR, Q177QL, V201I, T206S, T218SB
 33133313_1 None   K7KR, E11D, D25E, L101I, K111R, S119P, T122I, T124A, M154L, D256EB
 42514251_1 None   S39SC, M50I, S119P, T125A, M154L, D167E, V201I, K211R, T218IB
 30383038_1 None   S39C, G59E, T124N, T125A, V126L, M154L, V201IB
 31723172_1 None   P90PS, L101I, M154L, V201VIB
Capel (2013)107107KC238633None   E11D, K14R, S17T, V31I, I72V, T112A, T124A, T125A, M154LB
Kijak (2013)05TH35561405TH355614JN248343None   K7R, S17N, L28I, I84M, L101I, T124A, T125A, M154L, K211QB
 05TH64518905TH645189JN248353None   E11D, S24N, I60M, S119P, T125A, I135V, M154L, V165I, V201IB
Reigadas (2013)209209JX425676None   I72V, K111H, S119T, M154L, T206S, I208L, L234IB
 3131531315JX451901None   L45I, M50R, I72V, M154L, G193E, V201I, L234I, D286NB
Chikata (2014)KI-630KI-630AB873921None   E11D, D41N, I72V, I84M, T112V, T124TN, F139Y, M154L, S195C, I203MB
 KI-742KI-742AB874073None   V31I, L74I, T125A, M154L, K160KT, G163E, V165I, H171HQ, S195C, V201I, K215N, S230N, L234V, D279GB
 KI-552KI-552AB873909None   E11D, V32I, D41N, I72IV, I84M, T112V, M154L, S255CB
Martin (2014)ACU13ACU13KJ869622None   E11D, T122I, M154L, D167E, V201I, S283GB
Stekler (2014)PIC1889PGA52PIC1889PGA52KJ151995None   E10D, V31I, I72V, I84M, T124N, M154L, D167DY, V201I, N222KB
 PIC1897PGX53PIC1897PGX53KJ151980None   M50V, I72V, T122I, T124N, T125A, V126L, M154L, K211R, A265VB
Cuevas (2015)R14R14KT200350None   E11D, R20K, L28I, L101I, S119G, M154L, K156N, E157Q, V201I, T218S, Y227F, D256E, S283GB
Hachiya (2015)95229522LC022279None   E11D, L28LIM, V31VI, V32VI, I84M, L101LI, K103KR, T112V, T124N, M154L, V176VI, S195C, V201I, I203M, K215KN, S230NB
 95219521LC022278None   E11D, L28LIM, V31VI, V32VI, I84M, L101LI, K103KR, T112V, T124N, M154L, V165VI, S195C, V201I, I203M, K215N, S230NB
 92419241LC022390None   K14R, S39C, I84M, S119T, T124N, M154L, V201I, T206S, S230N, D232EB
 96809680LC022317None   E11D, K14KR, V31VI, V32VI, I72V, V77A, L101I, M154L, V165I, S195C, E198D, V201I, K215N, D279DGB
 94719471LC022206None   E11D, D25DE, I72V, L74V, L101I, T124TA, M154L, S195C, V201I, K215N, P233PL, D279GB
 96789678LC022205None   E11D, V31VI, L45LI, I72V, L101I, T112A, T125TA, I135V, M154L, S195C, V201I, K215N, D279GB
 N0664N0664LC022441None   I72V, M154L, S195C, E198D, V201IB
 93559355LC022204None   D6E, S17N, L101I, T124TA, M154LB
 96359635LC022343None   E11D, V31VI, L101I, E152EK, M154L, V165I, G189GR, S195C, V201I, K215N, N254ND, D279GB
 96869686LC022379None   L28LI, K42KR, L45LIV, I72V, L74I, P90S, T112A, T124N, T125A, M154L, S195C, S283GB
 N0671N0671LC022446None   E11D, I72V, L101I, M154L, S195C, V201I, K215N, D279DG, D286DNB
 97019701LC022154None   E11D, L28I, I72V, I84M, P90A, L101I, T112V, K136R, M154L, S195C, E198D, V201I, K215NB
 N0718N0718LC022479None   S24SG, L45LQ, I72V, P90A, L101I, T112V, T124TAGS, T125TM, M154L, V165I, V201I, S283GB
Han (2015)BJ2006001BJ2006001KP178421None   V31I, L101I, M154L, K156N, V201I, S230N, D278NB
Hora (2015)DEMB10TH002DEMB10TH002KP109514None   S17N, L28I, G59E, I72V, L101I, T124A, T125A, M154L, I162VB
Kinloch (2015)INT_165INT_165KT167724None   I72V, T112A, M154LB
 INT_99INT_99KT167658None   S24G, L28I, I72V, M154L, V165I, D167E, K211RB
 INT_258INT_258KT167817None   E11D, I72V, S119R, M154L, K211RB
Pessoa (2015)10BR_SP049SP049KJ849827None   E11D, S17N, A21S, I72V, I84M, G106A, T112M, S119P, T124S, M154L, V201I, I203M, T206S, D256EB
Li (2016)18451845KT191961None   S17N, V88I, A91T, L101I, S119T, T124N, T125A, M154L, K156N, V201I, T218S, I220LB