Integrase Inhibitors

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Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	M154L
Rx	II-naive
IncludeMixtures	No

References	25
Patients	67
Isolates	70

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	INIMinorDRMs	OtherMut	Subtype
Reinke (2001)	R104	R104	AF203330	None		E11D, S17T, V37M, I72V, T112V, S119P, T122I, M154L, V165I, V201I, S230N	B
Rousseau (2006)	Pt23	03PS045MB2	DQ396398	None		E11D, E13D, R20K, A21T, D41G, I72V, K111R, T124A, M154L, V165I, D207G, K211R, T218I, S230N	B
Badreddine (2007)	J11462	SB_J11462	DQ375276	None		V31VI, I72V, A91S, L101I, T124N, M154L, F181L, V201I, K211R, T218I	B
Lataillade (2007)	01-3751	ML_01-3751	EF472761	None	F121FS	E11D, D25E, V31I, I72V, S119P, T122I, T124A, M154L, V201I	B
	02-1435	ML_02-1435	EF472781	None		R20K, A23V, I72V, L101I, T124A, M154L, F181L, V201I, T206S, K219KR, Y227F, E246ED, S255N, D256E	B
Sa-Filho (2007)	BREPM1029	BREPM1029	EF637052	None		E11D, S17T, V37I, I72V, I84L, L101I, T112A, S119R, M154L, V165I, V201I, L234V, D256E	B
Brennan (2008)	ABB32-96	ABB32-96	EU618519	None		E11D, M50I, I72V, T124A, M154L, E157G, G193D, S195T, K211R, I268L, D270N	B
Buzon (2008)	Pt34	Pt34Y1996	EU883889	None		D6DE, S24G, D25E, S39C, D41N, I72V, I84IM, L101LI, M154L, V165I, V201I	B
		Pt34Y2000	EU883890	None		S24G, D25E, S39C, D41N, I72V, I84M, L101I, M154L	B
		Pt34Y2003	EU883891	None		S24G, D25E, S39C, D41N, I72V, I84IM, L101LI, T124TA, M154L, V165I, V201VI	B
		Pt34Y2005	EU883892	None		S24G, D25E, S39C, D41N, I72V, I84M, L101I, M154L, V165I, V201I	B
Matthews (2008)	PS045	PS045	FJ199626	None		E11D, E13D, R20K, A21T, D41G, I72V, K111R, T124A, M154L, V165I, D207G, K211R, T218I, S230N	B
Miura (2008)	BEC7	BEC7	EU517862	None		S24SG, I72V, K111KT, M154L, V165I, T206S	B
	BEC117	BEC117	EU517864	None		E11D, A21T, I72V, T112A, S119P, T124TA, M154L, I208L, Q252QK, I267IT	B
	BEC49	BEC49	EU517874	None		E11D, S24N, N27S, I72V, Q95H, M154L, V201I, I220M, N222H, S255R, A265V	B
	BEC121	BEC121	EU517896	None		I72V, L101I, M154L	B
Brumme (2009)	INT_3533	INT_3533	FJ812984	None		I72V, L74I, L101I, S119G, T122I, M154L	B
	INT_3577	INT_3577	FJ813028	None		C56CG, A91AS, L101I, S119SG, T122I, T124TA, M154L, V180VA, V201VI, A265AV	B
	INT_3584	INT_3584	FJ813035	None		E11D, I72V, S119AGPR, T122TI, T124TN, T125V, M154L, T218TI, I220L, Q221H	B
	INT_3662	INT_3662	FJ813113	None		E11D, V32I, I72V, T124S, T125M, V126M, M154L, V201I, T206S	B
	INT_3745	INT_3745	FJ813196	None		I72V, P90S, T124TA, M154L, K173R, V201I	B
	INT_3782	INT_3782	FJ813233	None		L101I, T124TA, M154L, L234I	B
	INT_3786	INT_3786	FJ813237	None		I72V, L101I, M154L, R284RG	B
	INT_3800	INT_3800	FJ813251	None		E11D, L28I, S39SC, I72V, T124A, M154L, I200L, V201I	B
	INT_3875	INT_3875	FJ813326	None		E11D, I72IV, L101I, T112TA, S119G, T122I, M154L, R187RK, S195T, D256E	B
	INT_3906	INT_3906	FJ813357	None		E11ED, I72V, T124S, T125M, V126M, M154L, V201I	B
	D3532	D3532	GQ371819	None		I72V, A133AG, M154L, Q164QH	B
	F2528	F2528	GQ371865	None		K14R, V31I, I72V, A91S, Q95H, T112I, I113V, S119P, T125A, M154L, V201I, T206S, D256E	B
	L8537	L8537	GQ371996	None		D6E, E11D, E13D, V31I, L101LI, T112AV, S119P, T122I, T124TA, M154L, D256E	B
	M4526	M4526	GQ372008	None		E11D, K14R, I72V, K103R, S119P, T122I, T124N, T125A, M154L, G189R, S195T, V201I, T218I, R262RK	B
	N6522	N6522	GQ372039	None		G70E, I72V, T124A, M154L, G193D, V201I, T206S, Q216H, Y226F, L234I, K266KR, I268L, D270H	B
	P4505	P4505	GQ372084	None		K14R, L28I, S39C, I84M, L101I, T124A, M154L, V201I, K240R	B
	V0570	V0570	GQ372200	None		E11D, H16HP, Q53QE, I72V, S119P, T122I, T124N, T125A, M154L, G193R, V201I, T206S	B
	V5578	V5578	GQ372210	None		I72V, I84M, S119P, M154L, V201I, A205S, T206S, D207E, T218I, D256DE	B
	X9501	X9501	GQ372267	None		I72V, K103K*, S119PT, T124N, T125TA, V126L, A133AG, M154L, I217IT, T218S	B
	Y1525	Y1525	GQ372275	None		K7R, V31I, I72V, L101I, K111KR, T124TA, I135V, M154L, F181L, T206S, I220M	B
Canducci (2009)	pt4	pt4bl	EU908759	None		D3Q, G70E, L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E	B
Garrido (2009)	154	INT-154	GU217001	None		A23V, I72V, M154L, V201I, D279N	B
	325	INT-325	GU217172	None		D25E, V31I, S39N, I72V, L101I, I113V, S119P, T124A, K136N, M154L, D253H	B
Kousiappa (2009)	CY037	CY037	FJ388899	None		E11D, S24A, I72V, S119P, M154L, T206S, T218S	B
	CY124	CY124	FJ388933	None		V31I, I72V, L101I, T112A, T124A, M154L	B
	CY031	CY031	FJ388897	None		V31I, I72V, L101I, T124A, M154L	B
	CY038	CY038	FJ388900	None		E11D, S24A, V31I, I72V, M154L, V201I, T206S, T218S, I220L	B
Low (2009)	F-15	F-15	FJ786302	None		I72V, T124N, T125A, V126L, M154L, V201I, T206S, C280S	B
	G-8	G-8	FJ786303	None		I72V, L101I, S119T, M154L, V201I, S283G	B
	ahi96	ahi96_03	FJ786364	None		S17N, I72V, T124N, T125A, I135V, M154L, V201I	B
	mdr3	mdr3	FJ786386	None		V31I, M50L, I72V, M154L, H171Q, V201I, T218S, S283G	B
Passaes (2009)	BR.RJ.FT46	BR.RJ.FT46	HM026767	None		K7R, E11D, V31I, I72V, L101V, M154L, T206S	B
Sichtig (2009)	21-E	21-E	FJ183544	None		E11D, K14R, A21T, V31I, V32I, I72V, I84MV, L101I, T122TI, T124A, T125A, I135V, M154L, V165I, S230N	B
Wang (2009)	L8124P	L8124P	FJ469741	None		I72V, L101I, T112I, S119P, T122I, T124N, T125A, M154L, D167E, V201I, T206S, I208M, D256E	B
	PRLS28	PRLS28	FJ469766	None		D25E, I72V, T124N, M154L	B
Arruda (2010)	EI018	EI018	GQ864173	None		E10D, K14T, L28I, S39C, I72V, I84M, E96A, I113L, T122I, T124N, N144H, M154L, K211R, D253E	B
Rangel (2010)	HIV202b	HIV202b	GU797510	None		I72V, I113V, T124N, M154L, V201I, T206S, S230SN, D256E	B
	HIV249p	HIV249p	GU797528	None		I72V, A91S, L101I, S119P, M154L, V201I, T206S, T210TI, K211KR, D256E	B
	HIV270b	HIV270b	GU797543	None		A23V, L101I, K103KR, M154L, T218S, D253E	B
	HIV270p	HIV270p	GU797544	None		A23V, I72IV, L101I, K111KR, M154L, Y194C, I204IK, T218S, D253E	B
Blanco (2011)	CA14192	CA124188		None		T112V, M154L, V201I, V259VI	B
Brenner (2011)	6799	6799	HQ207740	None		E11D, D25DE, V31I, I72V, T112A, T124N, T125I, M154L, D256E, S283G	B
	6852	6852	HQ207744	None		E11D, V31I, I72V, T112A, T124N, T125I, M154L, V165H, D256E, S283G	B
	6958	6958	HQ207745	None		E11D, D25DE, V31I, I72V, T112A, T124N, T125I, M154L, D256E, S283G	B
	9604	9604	HQ207797	None		V31I, I72V, T112A, T124N, T125M, M154L, S230N, D256E, S283G	B
Rolland (2011)	2495	consensus_2495	JF320054	None		E11D, A21T, M22I, A23V, L28M, V32I, I72V, I84M, T112A, S119P, T124A, T125A, M154L	B
	2000	consensus_2000	JF320276	None		S17N, V31I, I72V, L74V, T112A, T125A, V126M, M154L, V201VI, K211KR	B
	0388	consensus_0388	JF320315	None		E10D, L45V, I72V, L101I, K103R, S119P, T122I, M154L, K211R	B
	0176	consensus_0176	JF320363	None		I72V, P90S, T124N, T125V, M154L, K173R, V201I	B
	1709	consensus_1709	JF320460	None		V31VI, V32VI, L101I, T125TA, M154L, V165I, V201I, V281M	B
Brockman (2012)	AEHIV30	AEHIV30	JQ080114	None		R20K, I72V, K111R, M154L, T210I, K211R, D256E	B
Iamarino (2012)	BF.BR.0441	BF.BR.0441	JN234034	None		F100Y, L101I, T125A, M154L, L234V, D256E, S283G	B
Kijak (2012)	05TH355614	05TH355614	JN248343	None		K7R, S17N, L28I, I84M, L101I, T124A, T125A, M154L, K211Q	B
	05TH645189	05TH645189	JN248353	None		E11D, S24N, I60M, S119P, T125A, I135V, M154L, V165I, V201I	B

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