<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation M154L
Rx >=1 INI
IncludeMixtures No
References 6
Patients 24
Isolates 38
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Baldanti (2009)PV8PV8GU350728RAL26  K7Q, L101I, T125V, I135V, M154L, V165I, K211R, D256EB
 PV5PV5GU350729RAL26G140S, Q148H E13D, L101I, M154L, V165I, A196P, V201I, I208L, L234V, D256EB
Canducci (2009)pt4pt4W4EU908760RAL4 R263KD3Q, G70E, L101I, S119R, T124N, T125A, M154L, V165I, K211R, Q252X, D256E, R262EB
  pt4W12EU908761RAL13  D3Q, G70E, L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256EB
  pt4W24EU908762RAL26Y143CT97AD3Q, L101I, S119R, T124N, T125A, M154L, V165I, D256EB
  pt4w32EU908763RAL35Y143CT97AD3Q, L101I, S119R, T124N, T125A, M154L, V165I, K211KR, D256EB
  pt4w36EU908764RAL39Y143CL74M, T97AD3Q, L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256EB
Blanco (2011)CA5016CA128616 RAL29  S119G, T122I, T125A, M154L, I203M, L234I, D256EB
 CA14192CA128613 RAL35  T112V, M154L, V201IB
Canducci (2011)Pt2Pt2W24JN163881RAL26Y143CT97AL101I, S119R, T124N, T125A, M154L, V165I, D256E, G277CB
  Pt2W36JN163882RAL35 L74M, T97A, Y143GL101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G277CB
  Pt2W37JN163883RAL36 L74M, T97A, Y143GI36V, L101I, S119R, T124N, T125A, M154L, V165I, D256EB
  Pt2W56JN163884RAL55Y143RT97AL101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G277RB
  Pt2W64JN163885RAL64E138A, Y143CL74M, T97AL101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G272E, G277RB
Molina (2012)40204020_2 EVG73  V31I, P90S, T112AV, T124A, G134GS, M154L, K211R, T218S, S230N, S283GB
 33253325_2 RAL81  R20RK, V31I, E48EK, L101I, I113IV, S119ST, T125A, M154L, K173R, F181L, G193E, T206S, T210I, T218I, I220V, L234H, D279GB
 32693269_2 EVG20  S39C, M50I, L101I, S119P, T125TA, M154L, V201I, T206S, T218S, S255SGB
  3269_3 EVG48 T97TAS39C, M50I, V77VA, L101I, S119P, M154L, V201I, T206S, T218SB
  3269_4 EVG58 T97AS39C, M50I, L101I, S119P, M154L, V201I, T206S, T218SB
 33133313_2 EVG35  K7KR, E11D, D25E, I36IM, M50MV, L101I, K111R, S119P, T122I, T124A, M154L, D256EB
  3313_3 EVG81  K7KR, E11D, D25DE, F26FY, P90PS, L101I, K111R, S119P, T122I, T124A, M154L, D256EB
  3313_4 EVG96  K7KR, E11D, D25E, L101I, K111R, S119P, T122I, T124A, M154L, D256EB
 42514251_2 RAL76  M50I, D55G, V75I, I84M, Q95QR, S119P, T125A, M154L, D167E, V201I, K211R, T218IB
 30383038_2 EVG13  S39C, G59E, T124N, T125A, V126L, M154L, V201I, P233PS, L234LFB
  3038_3 EVG48  S39C, G59E, T124N, T125A, V126L, M154L, K173KR, V201IB
  3038_4 EVG56  S39C, G59E, T124N, T125A, V126L, M154L, V201IB
 31723172_2 EVG47T66TA, N155NH L101LI, M154L, V201I, D232DNB
Hurt (2014)IN_1391IN_1391 RAL Y143CT97A, S230RK14R, V31I, Q95A, L101I, S119T, T124A, M154L, V201IB
 IN_309IN_309 RAL E138EK, G140S, Q148H E11D, V31I, M154L, V201I, T218SB
 IN_1204IN_1204 RAL E138EAKT, G140S, Q148H E11D, V31I, T93TN, L101I, K136KE, M154L, S195C, T218S, K219N, I220IL, N222K, S283G, R284GB
 IN_1612IN_1612 RAL E138A, G140S, Q148HL68LVM50I, I72IV, I113V, T124N, T125A, M154L, D167E, V201IB
 IN_1611IN_1611 RAL E138A, G140S, Q148HL68LVM50I, I72IV, I113V, T124N, T125A, M154L, D167E, V201IB
 IN_1465IN_1465 RAL G140S, Q148H V31VI, M50I, I72V, L101I, M154L, I162VB
 IN_2704IN_2704 RAL N155H E10A, E11D, A21T, M50I, L101I, T112A, S119P, T122I, M154LB
 IN_1444IN_1444 RAL N155HG163GRS17N, L45Q, I72V, I84M, L101I, M154L, V201VI, I208L, K211Q, Q216NT, I220L, Q221H, D270H, D278DA, R284GB
 IN_1757IN_1757 RAL F121Y S24N, L101I, T112A, S119P, T124TN, T125A, M154L, Q177L, D232NSB
 IN_1619IN_1619 RAL E138A, G140S, Q148HL68LVM50I, I72IV, I113V, T124N, T125A, M154L, D167E, V201IB
 IN_2303IN_2303 RAL N155HE138ED, G163RM50I, L101LI, M154L, V201I, K211RB