<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation M154I
Rx II-naive
IncludeMixtures No
References 34
Patients 101
Isolates 105
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Skinner (1998)2ED002 None   D41N, I72V, M154I, K211RB
Hierholzer (2002)BK132BK132AY173951None   I72V, M154IB
 US1US1AY173952None   S17N, I72V, I84V, T124A, M154I, K173RB
Swanson (2003)BK132BK132AY214056None   I72V, T125TM, M154IB
 US1US1_2AY214059None   S17N, I72V, I84V, T124A, M154I, K173RB
Sierra (2004)V62V62AY536236None   I72V, T124A, M154I, V165I, F185Y, R187K, S283GB
Brown (2005)BB_85US_Ba-L85US_Ba-LAY713409None   V88I, M154IB
de Sa Filho (2005)BREPM107BREPM107AY771588None   S17N, V32I, S57N, I60M, I72V, S119T, M154I, V165I, V201I, T206S, L234V, D256E, V281M, S283GB
de Sa Filho (2006)BREPM11884BREPM11884DQ085868None   E11D, L101I, M154I, H171Y, V201I, D256E, S283GB
Sanabani (2006)02BR00602BR006DQ358807None   L101I, M154I, V201I, A205S, I251L, D256E, S283GB
Andresen (2007)PMVL 039PMVL 039EF514703None   S39C, L45V, L101I, M154I, V165I, R187K, K211R, K215NB
Brennan (2007)01BAB05501BAB055EF150549None   I72V, S119T, T124A, S153A, M154I, V165I, G193R, V201I, A265VB
 01BAB06301BAB063EF150555None   I72IV, T124A, M154I, V165I, R187K, V201VIB
 01BAB03401BAB034EF150619None   E11D, K14R, S17T, M50I, I72V, T124A, M154I, V165I, V201I, T206S, Y227F, L234V, D256E, S283GB
 01CEB07901CEB079EF150626None   E11D, M50I, I72V, I84L, L101LI, M154I, V165I, V201I, A205S, L234VB
Lataillade (2007)03-5187ML_03-5187EF472782None   K7Q, T112TP, T124N, T125A, V126L, M154I, V201I, I220VB
Buzon (2008)Pt17Pt17Y2004EU883839None   E10D, M50I, I84V, M154I, V201I, T206SB
 Pt41Pt41Y1995EU883905None   E10D, T124A, M154I, K211R, D253DEB
  Pt41Y2005EU883906None   E10D, M50I, L101I, M154I, I162IL, H171HL, V201I, K211RB
Miura (2008)BEC33BEC33EU517866None   S17N, I72V, T112A, T122I, T124A, M154I, A265VB
 BEC51BEC51EU517876None   D6DN, V31I, I72IV, T112A, T124N, M154I, I191LB
 BEC59BEC59EU517880None   E10G, T125A, M154I, N222NH, L234VB
 BEC71BEC71EU517886None   L101I, T125A, M154I, I162V, V165I, K173R, V176I, F181L, R187K, V201I, N254H, D256EB
 BEC77BEC77EU517887None   E10V, A21T, I72V, M154I, A265VB
Brumme (2009)INT_3493INT_3493FJ812944None   S17SN, V31VIM, I72V, L101LI, M154I, V201VI, T218TSB
 INT_3522INT_3522FJ812973None   S17N, I72V, K111R, S119T, T124A, M154I, K188KRB
 INT_3589INT_3589FJ813040None   S17SN, L101I, M154I, K173KR, V176VLB
 INT_3610INT_3610FJ813061None   L45I, M154I, V201IB
 INT_3681INT_3681FJ813132None   S17SN, T112V, T124N, M154I, V201VIB
 INT_3773INT_3773FJ813224None   M50MIT, I72V, A91AG, T122TI, T124TN, T125TAIV, V126VA, M154IB
 INT_3903INT_3903FJ813354None   E11D, A21T, A23V, L101I, M154I, N222NTB
 INT_3910INT_3910FJ813361None   A21AT, L45I, L63LI, L101I, M154I, R187K, L242LFB
 B3506B3506GQ371794None   I72IN, K111KR, M154I, K188KR, R228RGB
 B3535B3535GQ371796None   E11D, S17N, D25E, L45I, I72V, I84L, L101I, T124TA, M154I, V165I, K188R, K211T, V259I, S283G, D288NB
 B7521B7521GQ371807None E138K E11D, K14R, S24N, I84IV, T125A, M154I, K156N, V201I, K211RB
 D5513D5513GQ371825None   V31I, T124N, T125A, K136Q, M154I, F185FY, L234V, D253E, R262RK, E287AB
 F4520F4520GQ371871None   I72V, I84V, K111R, M154I, D167E, V201IB
 J9520J9520GQ371951None   D25E, K34R, I72V, F100S, L101I, T125A, M154I, V165I, K173KN, V201I, T206S, R262RK, D270EB
 M1546M1546GQ372004None   K14KR, M50I, L74I, I84IV, M154I, V201IB
 N5523N5523GQ372036None   S17N, T124N, T125A, M154I, V165I, V201I, R269KB
 P3502P3502GQ372080None  L68VS17N, D41N, M50I, P90S, S119R, T124N, M154I, G163E, K211R, D256EB
 P8578P8578GQ372096None   K7Q, N27G, T124N, M154I, V201I, L234I, R262RK, S283GB
 V5522V5522GQ372209None  V54IE10D, M50I, T124A, M154I, Q216NB
 X3522X3522GQ372252None   S24G, V32I, D41N, I72V, T124N, T125A, K136Q, M154I, V165I, V201IB
 Y4518Y4518GQ372283None   S17N, V31VIM, I72V, T124N, M154I, Q164QH, V165VI, Y227F, D256EB
Eshleman (2009)ARG2982ARG2982FJ480322None   E10D, I72IV, T124TA, M154I, V165I, L234V, D256E, S283GB
 BrRJ96-002BrRJ96-002FJ480324None   S24N, L28I, M154I, V165I, V201I, I208L, Q216HB
Garrido (2009)83INT-83GU216930None   S17N, V31I, M50I, I72V, N117HY, T124A, K127R, M154I, I162KN, R166RK, V201I, D253DE, D279NB
 87INT-87GU216934None   D3G, G4G*, S17N, L101I, T112V, S119T, T124N, M154I, V201I, D256E, D279DNB
 261INT-261GU217108None   D6E, E10D, S17T, S119P, T122I, T124N, T125A, M154IB
Low (2009)A-6A-6FJ786270None   M154I, V201IB
 mdr11mdr11FJ786396None   E10K, D25K, E69K, I72V, L101I, K111Q, S119G, T122I, M154I, E157K, V201I, L234V, D256EB
Nadai (2009)129473129473EU839603None   I72V, T124A, M154I, I208L, K211R, E212I, Q216H, V260IB
Passaes (2009)BR.RJ.FT36BR.RJ.FT36HM026765None   E10D, I60M, M154I, D167E, N254S, S255G, V281MB
Sichtig (2009)24732473FJ183513None   R20K, I72V, L101I, M154I, V165I, I182V, V201IB
 10-E10-EFJ183515None   K14KR, S17N, R20RK, M22MR, I72V, I113V, S119T, T124A, M154I, V165I, V201I, T206TS, I208IL, T218TSB
 29-E29-EFJ183526None   M154I, V201I, T218SB
 48344834FJ183622None   R20RK, S39ST, I72V, L101I, M154I, G193EB
 57605760FJ183676None   K14KR, M154I, V201I, D229EB
van Hal (2009)W82W82FJ554755None   E10D, K14R, I72V, S119G, T122I, T125A, M154I, V201I, R284G, Q285RB
Wang (2009)F706F706FJ469728None   S24G, D41N, I72V, M154IB
 L827L827FJ469747None  G163RE10D, I72V, T125A, M154I, K156N, V201I, D256EB
 PRLS01PRLS01FJ469753None   S17N, I72V, L101I, K111R, S119P, T124A, T125A, M154I, K211Q, T218I, D232E, D256EB
 PRLS12PRLS12FJ469759None   D6E, E11D, A21T, I72V, I84V, S119P, T124N, T125A, V126L, M154IB
 PRLS17PRLS17FJ469761None   Q62R, I84V, T122I, T125A, M154I, K211R, K219N, N222KB
 SH8183SH8183FJ469768None   E10A, E11D, A21T, I84V, T112R, S119P, T122I, T125A, M154I, L234IB
Rangel (2010)N477pN477pGU797498None   L28I, P30A, I72V, L101I, T112A, S119T, T125A, M154I, T206S, K215N, N222KB
Brenner (2011)INT10INT10HQ207809None  L74LIMI60IM, I84M, L101I, M154I, G163A, K173KR, V201I, A205SB
Rolland (2011)1399consensus_1399JF320012None   I84V, L101I, T112A, T125A, M154I, V165I, Q177L, F181Y, L234IB
 1512consensus_1512JF320356None   S17N, M50I, I72V, I84V, P90A, T124A, M154I, V201I, D253E, D256EB
Sanabani (2011)BR2025BR2025JN692435None   S17N, V31I, I72V, P90S, T124N, V126L, M154I, V201I, T218SB
 BR1079BR1079JN692462None   S17N, L28I, I72V, T124A, M154I, T206S, Y227F, L234H, D256E, R284GB
Armenia (2012)PT_63PT_63_BLJN544098None   S24N, D25DE, L101I, T124Q, T125M, M154I, V165I, D232E, L234VB
Brockman (2012)AEHIV56AEHIV56JQ080140None   L45I, M154I, V201IB
Iamarino (2012)BF.BR.1470BF.BR.1470JN234040None   E11D, S17N, M50L, I72V, I84M, I113V, S119T, T124N, T125A, M154I, V165I, V201I, L234V, D256E, S283GB
 BF.BR.1027BF.BR.1027JN234054None   S17N, A21S, A23V, D25E, V31I, E69K, G70E, I113V, T124A, T125A, M154I, E157K, D167E, T206S, D253EB
 BF.BR.1038BF.BR.1038JN234056None  V151IS17N, A21S, A23V, V31I, L101I, T112I, M154I, V201I, T206SB
 B.BR.1009B.BR.1009JN234114None   S24G, D25E, L45I, S119G, T122I, T124N, T125A, M154I, V165I, K211R, I220VB
 B.BR.1039B.BR.1039JN234120None   S17N, I72V, T124A, M154I, V165I, V201I, D229E, S230N, S283GB
 B.BR.1546B.BR.1546JN234179None   K7R, I72V, T124A, M154I, V201IB
Manak (2012)63_LH0163_LH01JN687678None   K7R, A21T, L101I, M154I, K219N, N222KB
Rolland (2012)AA040a_WG13AA040a_WG13JX447158None E138KT97AG70E, L101I, S119R, T124N, T125S, M154I, K211RB
Capel (2013)3737KC238587None   D6X, L28I, I72V, M154IB
 5050KC238594None   S24N, I72V, M154IB
 3838KC238588None   D6E, M154IB
 137137KC238661None   E10D, I72V, T112I, T125V, M154I, V165I, V201IB
Reigadas (2013)330330JX425451None   S17N, I72V, I113V, T124A, T125A, M154I, V165I, R187TB
 1616JX425484None   S17N, I72V, I113IV, T124N, T125MV, M154I, S230N, D256DEB
 3737JX425505None   D25E, M154I, K188R, V201I, T218I, L234VB
 4141JX425509None   S17N, M154I, V201IB
 145145JX425613None   K7R, K14R, S24G, L28I, P30A, I72V, T93N, T124A, M154I, V165I, K211P, T218S, I220V, D253HB
 153153JX425620None   S17N, M50I, I84IV, T124TA, M154I, V201I, T218SB
 176176JX425643None   S17N, I72V, L74I, I84V, L101I, M154I, V165I, H171L, T218S, I251IT, D256DEB
 185185JX425652None   E10D, L101I, S119G, T122I, T124N, M154I, V165IB
 187187JX425654None   E11D, S17C, L101V, K111T, S119G, T124N, T125A, M154I, V165IB
 207207JX425674None   S17N, L101I, T125A, M154I, V165I, V201I, K215N, D256E, Q285PB
 218218JX425685None   S17N, V31I, I72V, L101I, M154I, V201I, Q209P, K215N, Q216PB
 229229JX425696None   K14R, I84V, M154I, V201I, S230N, L234H, R284GB
 257257JX425724None   D3DE, E10D, K34R, L101I, T112A, T125A, M154I, N254QB
 264264JX425731None   E11D, K14R, S24G, D25E, L28I, L45V, L101I, K136N, M154I, R187K, T218S, I220L, S230N, D279GB
Chikata (2014)KI-767KI-767AB874093None   E10D, T125A, Q137QH, M154I, V201IB
 KI-644KI-644AB874005None   S17C, L101I, I113V, S119T, T124A, T125A, M154I, V165I, V201I, L234I, D253EB
 KI-823KI-823AB874146None   V31VI, V32VI, S39C, S57N, I84M, S119T, T124N, M154I, V201I, T206S, K215NB
 KI-908KI-908AB874205None   K14R, S17C, A76AS, I84M, L101I, T124A, T125A, M154I, V165I, A196P, V201IB
 KI-573KI-573AB873935None   L68A, G70E, L101I, T112A, S119R, T125A, M154I, H171Q, K173R, R187K, L234IB