<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation M154I
Rx II-naive
IncludeMixtures No
References 44
Patients 199
Isolates 203
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Skinner (1998)2ED002 None   D41N, I72V, M154I, K211RB
Hierholzer (2002)BK132BK132AY173951None   I72V, M154IB
 US1US1AY173952None   S17N, I72V, I84V, T124A, M154I, K173RB
Swanson (2003)BK132BK132AY214056None   I72V, T125TM, M154IB
 US1US1_2AY214059None   S17N, I72V, I84V, T124A, M154I, K173RB
Sierra (2004)V62V62AY536236None   I72V, T124A, M154I, V165I, F185Y, R187K, S283GB
Brown (2005)BB_85US_Ba-L85US_Ba-LAY713409None   V88I, M154IB
de Sa Filho (2005)BREPM107BREPM107AY771588None   S17N, V32I, S57N, I60M, I72V, S119T, M154I, V165I, V201I, T206S, L234V, D256E, V281M, S283GB
de Sa Filho (2006)BREPM11884BREPM11884DQ085868None   E11D, L101I, M154I, H171Y, V201I, D256E, S283GB
Sanabani (2006)02BR00602BR006DQ358807None   L101I, M154I, V201I, A205S, I251L, D256E, S283GB
Andresen (2007)PMVL 039PMVL039EF514703None   S39C, L45V, L101I, M154I, V165I, R187K, K211R, K215NB
Brennan (2007)01BAB05501BAB055EF150549None   I72V, S119T, T124A, S153A, M154I, V165I, G193R, V201I, A265VB
 01BAB06301BAB063EF150555None   I72IV, T124A, M154I, V165I, R187K, V201VIB
 01BAB03401BAB034EF150619None   E11D, K14R, S17T, M50I, I72V, T124A, M154I, V165I, V201I, T206S, Y227F, L234V, D256E, S283GB
 01CEB07901CEB079EF150626None   E11D, M50I, I72V, I84L, L101LI, M154I, V165I, V201I, A205S, L234VB
Lataillade (2007)58BML_58BEF472779None   L2LF, K7KN, S17N, V31V*EL, I72V, T124N, M154I, D256DEB
 03-5187ML_03-5187EF472782None   K7Q, T112TP, T124N, T125A, V126L, M154I, V201I, I220VB
Buzon (2008)Pt17Pt17Y2004EU883839None   E10D, M50I, I84V, M154I, V201I, T206SB
 Pt41Pt41Y1995EU883905None   E10D, T124A, M154I, K211R, D253DEB
  Pt41Y2005EU883906None   E10D, M50I, L101I, M154I, I162IL, H171HL, V201I, K211RB
Miura (2008)BEC33BEC33EU517866None   S17N, I72V, T112A, T122I, T124A, M154I, A265VB
 BEC51BEC51EU517876None   D6DN, V31I, I72IV, T112A, T124N, M154I, I191LB
 BEC59BEC59EU517880None   E10G, T125A, M154I, N222NH, L234VB
 BEC71BEC71EU517886None   L101I, T125A, M154I, I162V, V165I, K173R, V176I, F181L, R187K, V201I, N254H, D256EB
 BEC77BEC77EU517887None   E10V, A21T, I72V, M154I, A265VB
Brumme (2009)INT_3493INT_3493FJ812944None   S17SN, V31VIM, I72V, L101LI, M154I, V201VI, T218TSB
 INT_3522INT_3522FJ812973None   S17N, I72V, K111R, S119T, T124A, M154I, K188KRB
 INT_3589INT_3589FJ813040None   S17SN, L101I, M154I, K173KR, V176VLB
 INT_3610INT_3610FJ813061None   L45I, M154I, V201IB
 INT_3681INT_3681FJ813132None   S17SN, T112V, T124N, M154I, V201VIB
 INT_3773INT_3773FJ813224None   M50MIT, I72V, A91AG, T122TI, T124TN, T125TAIV, V126VA, M154IB
 INT_3903INT_3903FJ813354None   E11D, A21T, A23V, L101I, M154I, N222NTB
 INT_3910INT_3910FJ813361None   A21AT, L45I, L63LI, L101I, M154I, R187K, L242LFB
 B3506B3506GQ371794None   I72IN, K111KR, M154I, K188KR, R228RGB
 B3535B3535GQ371796None   E11D, S17N, D25E, L45I, I72V, I84L, L101I, T124TA, M154I, V165I, K188R, K211T, V259I, S283G, D288NB
 B7521B7521GQ371807None E138K E11D, K14R, S24N, I84IV, T125A, M154I, K156N, V201I, K211RB
 D5513D5513GQ371825None   V31I, T124N, T125A, K136Q, M154I, F185FY, L234V, D253E, R262RK, E287AB
 F4520F4520GQ371871None   I72V, I84V, K111R, M154I, D167E, V201IB
 J9520J9520GQ371951None   D25E, K34R, I72V, F100S, L101I, T125A, M154I, V165I, K173KN, V201I, T206S, R262RK, D270EB
 M1546M1546GQ372004None   K14KR, M50I, L74I, I84IV, M154I, V201IB
 N5523N5523GQ372036None   S17N, T124N, T125A, M154I, V165I, V201I, R269KB
 P3502P3502GQ372080None  L68VS17N, D41N, M50I, P90S, S119R, T124N, M154I, G163E, K211R, D256EB
 P8578P8578GQ372096None   K7Q, N27G, T124N, M154I, V201I, L234I, R262RK, S283GB
 T9507T9507GQ372193None   D6E, E10D, M50I, I72IN, L74I, F139FINY, I141IT, P142PL, M154I, L234H, D253E, D256EB
 V5522V5522GQ372209None  V54IE10D, M50I, T124A, M154I, Q216NB
 W9532W9532GQ372243None   D6E, S17N, I60M, L101I, T124A, T125M, I135V, M154I, V165I, Q216H, K219Q, N222NI, D278NB
 X3522X3522GQ372252None   S24G, V32I, D41N, I72V, T124N, T125A, K136Q, M154I, V165I, V201IB
 Y4518Y4518GQ372283None   S17N, V31VIM, I72V, T124N, M154I, Q164QH, V165VI, Y227F, D256EB
Eshleman (2009)ARG2982ARG2982FJ480322None   E10D, I72IV, T124TA, M154I, V165I, L234V, D256E, S283GB
 BrRJ96-002BrRJ96-002FJ480324None   S24N, L28I, M154I, V165I, V201I, I208L, Q216HB
Garrido (2009)83INT-83GU216930None   S17N, V31I, M50I, I72V, N117HY, T124A, K127R, M154I, I162KN, R166RK, V201I, D253DE, D279NB
 87INT-87GU216934None   D3G, G4G*, S17N, L101I, T112V, S119T, T124N, M154I, V201I, D256E, D279DNB
 261INT-261GU217108None   D6E, E10D, S17T, S119P, T122I, T124N, T125A, M154IB
Low (2009)A-6A-6FJ786270None   M154I, V201IB
Nadai (2009)129473129473EU839603None   I72V, T124A, M154I, I208L, K211R, E212I, Q216H, V260IB
Passaes (2009)BR.RJ.FT36BR.RJ.FT36HM026765None   E10D, I60M, M154I, D167E, N254S, S255G, V281MB
Sichtig (2009)24732473FJ183513None   R20K, I72V, L101I, M154I, V165I, I182V, V201IB
 10-E10-EFJ183515None   K14KR, S17N, R20RK, M22MR, I72V, I113V, S119T, T124A, M154I, V165I, V201I, T206TS, I208IL, T218TSB
 29-E29-EFJ183526None   M154I, V201I, T218SB
 48344834FJ183622None   R20RK, S39ST, I72V, L101I, M154I, G193EB
 57605760FJ183676None   K14KR, M154I, V201I, D229EB
Wang (2009)F706F706FJ469728None   S24G, D41N, I72V, M154IB
 L827L827FJ469747None  G163RE10D, I72V, T125A, M154I, K156N, V201I, D256EB
 PRLS01PRLS01FJ469753None   S17N, I72V, L101I, K111R, S119P, T124A, T125A, M154I, K211Q, T218I, D232E, D256EB
 PRLS12PRLS12FJ469759None   D6E, E11D, A21T, I72V, I84V, S119P, T124N, T125A, V126L, M154IB
 PRLS17PRLS17FJ469761None   Q62R, I84V, T122I, T125A, M154I, K211R, K219N, N222KB
 SH8183SH8183FJ469768None   E10A, E11D, A21T, I84V, T112R, S119P, T122I, T125A, M154I, L234IB
Rangel (2010)N477pN477pGU797498None   L28I, P30A, I72V, L101I, T112A, S119T, T125A, M154I, T206S, K215N, N222KB
Brenner (2011)INT10INT10HQ207809None  L74LIMI60IM, I84M, L101I, M154I, G163A, K173KR, V201I, A205SB
Rolland (2011)1399consensus_1399JF320012None   I84V, L101I, T112A, T125A, M154I, V165I, Q177L, F181Y, L234IB
 1512consensus_1512JF320356None   S17N, M50I, I72V, I84V, P90A, T124A, M154I, V201I, D253E, D256EB
Sanabani (2011)BR2025BR2025JN692435None   S17N, V31I, I72V, P90S, T124N, V126L, M154I, V201I, T218SB
 BR1067BR1067JN692456None   S17N, I72V, L101I, S119T, T124A, M154I, V165I, V201I, T218I, L234V, D256E, S283GB
 BR1079BR1079JN692462None   S17N, L28I, I72V, T124A, M154I, T206S, Y227F, L234H, D256E, R284GB
Armenia (2012)PT_63PT_63_BLJN544098None   S24N, D25DE, L101I, T124Q, T125M, M154I, V165I, D232E, L234VB
Brockman (2012)AEHIV56AEHIV56JQ080140None   L45I, M154I, V201IB
Iamarino (2012)BF.BR.1470BF.BR.1470JN234040None   E11D, S17N, M50L, I72V, I84M, I113V, S119T, T124N, T125A, M154I, V165I, V201I, L234V, D256E, S283GB
 BF.BR.1027BF.BR.1027JN234054None   S17N, A21S, A23V, D25E, V31I, E69K, G70E, I113V, T124A, T125A, M154I, E157K, D167E, T206S, D253EB
 BF.BR.1038BF.BR.1038JN234056None  V151IS17N, A21S, A23V, V31I, L101I, T112I, M154I, V201I, T206SB
 B.BR.1009B.BR.1009JN234114None   S24G, D25E, L45I, S119G, T122I, T124N, T125A, M154I, V165I, K211R, I220VB
 B.BR.1039B.BR.1039JN234120None   S17N, I72V, T124A, M154I, V165I, V201I, D229E, S230N, S283GB
 B.BR.1546B.BR.1546JN234179None   K7R, I72V, T124A, M154I, V201IB
Molina (2012)40424042_1 None   R20RK, I84IV, L101I, T112TI, T125TA, M154I, V165I, H171L, K211RB
 34653465_1 None   E10D, T124N, T125A, I135IV, M154I, P261F, R262FB
 33523352_1 None   I89IV, L101I, V110VI, T124A, T125A, M154I, H171Y, R187K, T206S, K211RB
Rolland (2012)AA040a_WG13AA040a_WG13JX447158None E138KT97AG70E, L101I, S119R, T124N, T125S, M154I, K211RB
Capel (2013)3737KC238587None   D6DE, L28I, I72V, M154IB
 5050KC238594None   S24N, I72V, M154IB
 3838KC238588None   D6E, M154IB
 137137KC238661None   E10D, I72V, T112I, T125V, M154I, V165I, V201IB
Reigadas (2013)330330JX425451None   S17N, I72V, I113V, T124A, T125A, M154I, V165I, R187TB
 1616JX425484None   S17N, I72V, I113IV, T124N, T125MV, M154I, S230N, D256DEB
 3737JX425505None   D25E, M154I, K188R, V201I, T218I, L234VB
 4141JX425509None   S17N, M154I, V201IB
 145145JX425613None   K7R, K14R, S24G, L28I, P30A, I72V, T93N, T124A, M154I, V165I, K211P, T218S, I220V, D253HB
 153153JX425620None   S17N, M50I, I84IV, T124TA, M154I, V201I, T218SB
 176176JX425643None   S17N, I72V, L74I, I84V, L101I, M154I, V165I, H171L, T218S, I251IT, D256DEB
 185185JX425652None   E10D, L101I, S119G, T122I, T124N, M154I, V165IB
 187187JX425654None   E11D, S17C, L101V, K111T, S119G, T124N, T125A, M154I, V165IB
 207207JX425674None   S17N, L101I, T125A, M154I, V165I, V201I, K215N, D256E, Q285PB
 218218JX425685None   S17N, V31I, I72V, L101I, M154I, V201I, Q209P, K215N, Q216PB
 229229JX425696None   K14R, I84V, M154I, V201I, S230N, L234H, R284GB
 257257JX425724None   D3DE, E10D, K34R, L101I, T112A, T125A, M154I, N254QB
 264264JX425731None   E11D, K14R, S24G, D25E, L28I, L45V, L101I, K136N, M154I, R187K, T218S, I220L, S230N, D279GB
Chikata (2014)KI-767KI-767AB874093None   E10D, T125A, Q137QH, M154I, V201IB
 KI-644KI-644AB874005None   S17C, L101I, I113V, S119T, T124A, T125A, M154I, V165I, V201I, L234I, D253EB
 KI-823KI-823AB874146None   V31VI, V32VI, S39C, S57N, I84M, S119T, T124N, M154I, V201I, T206S, K215NB
 KI-908KI-908AB874205None   K14R, S17C, A76AS, I84M, L101I, T124A, T125A, M154I, V165I, A196P, V201IB
 KI-573KI-573AB873935None   L68A, G70E, L101I, T112A, S119R, T125A, M154I, H171Q, K173R, R187K, L234IB
Martin (2014)CHR5CHR5KJ869728None  L74LMK7KQ, R20RK, S24SN, N27G, T124N, T125TA, M154I, V201I, L234IB
Stekler (2014)PIC1895PHM57PIC1895PHM57KJ152011None   L45Q, M154I, S195T, V201I, L234VB
 PIC1876PFW53PIC1876PFW53KJ152022None   L45Q, M154I, S195T, V201I, L234VB
Hachiya (2015)N0734N0734LC022484None   K14R, S17C, I84L, L101I, G106GE, T124A, T125A, M154I, V165I, E198D, V201IB
 D9668D9668LC022632None   M50I, L74I, M154I, K156N, I208LB
 D9691D9691LC022618None   D6E, E11D, S17N, T112A, T124N, T125A, M154IB
Hora (2015)DEMB09US003DEMB09US003KC473824None   S17N, V31I, M50I, D55N, T122I, T124N, T125A, E152K, M154I, K211R, S230N, A265VB
Kinloch (2015)INT_69INT_69KT167628None  V151IE10ED, E11D, E13ED, S24SN, V31VI, H51HP, Q53QP, I72V, L101I, S119P, T122I, T124A, M154I, T206S, S255SR, D256EB
 INT_206INT_206KT167765None   I72V, M154I, S255R, A265VB
 INT_184INT_184KT167743None   K7R, L28I, L45T, I72V, T122TI, M154IB
 INT_63INT_63KT167622None   S17N, I72V, M154I, V201VI, D256EB
 INT_217INT_217KT167776None   I72V, M154I, I162VB
Pessoa (2016)10BR_MG03010BR_MG030KT427679None   D6E, E10D, M50T, Q137H, M154I, V201I, L234V, K273RB
Worobey (2016)SF3SF3KJ704796None   I72V, T112A, M154I, R166RK, A265VB
 SF20SF20KJ704794None   I72V, T112A, M154I, A265VB
 SF4SF4KJ704795None   I72V, T112A, M154I, A265V, M275IB
Bradley-Stewart (2017)WoSSVC_INT90WoSSVC_INT90MF442529None   E11D, S24N, L101I, S119G, T125V, M154I, K211RB
Chen (2017)225510402225510402KY574999None   S24G, I72V, L101I, K111A, T124N, I135IV, M154I, V165I, K173KR, T218XB
 225510310225510310KY574998None   S17N, M50I, T124N, T125A, M154I, V201I, D256EB
 219512020219512020KY574955None   S17N, D41DN, I72V, T124A, M154IB
 216511348216511348KY574921None   E10D, K14KR, M154I, G163GA, V201VI, K211R, D256DEB
 216511335216511335KY574920None   K7R, K34R, I72V, L74I, T125M, M154I, V201VI, S283GB
Hachiya (2017)A14-2010191LC160380LC160380None   E11D, S17C, I72V, G106A, T112R, T124N, M154I, V201I, T218S, K219N, N222KB
 B15-5110117LC160429LC160429None   K14R, S39M, I72V, T112V, S153SA, M154I, V201IB
 C10-000710058419LC160444LC160444None   K14R, S17C, L101I, I113V, T124A, T125A, M154I, V165I, Q177L, V201I, T218SB
 C14-51111607LC160864LC160864None   E11D, R20K, L28I, V37I, I72V, L101I, S119G, T122I, T124A, T125A, M154I, K156N, E157Q, K215N, Q221S, N222KB
 C14-51111627LC160884LC160884None   E10D, E13D, S39R, L45V, G70S, L101I, M154I, G163E, V201IB
 C15-55552433720LC161193LC161193None   S24SG, L45X, S57N, M154I, V201I, Q216NB
 E15-50911512LC161439LC161439None   I72IV, L74LI, L101X, K103R, T124A, M154I, H171Y, K173KR, I200L, V201I, I203M, T218S, P233PLB
 H14-20112LC161584LC161584None   S17N, I72IT, I84M, L101I, M154I, V201I, A205SB
 H14-201110LC161592LC161592None   S17N, I84M, A98E, L101I, P109S, F121X, T124TS, M154I, L234LIB
 H14-201121LC161603LC161603None   S17N, I84M, L101X, M154I, L234IB
 C14-2069063LC171085LC171085None   E11D, R20K, L28I, V37I, I72V, L101I, S119G, T122I, T124A, T125A, M154I, K156N, E157Q, K215N, Q221S, N222KB
 C14-2069102LC171116LC171116None   S17N, I84M, L101I, M154I, D288NB
 C15-2069077LC171192LC171192None   K14R, S17C, L101I, I113V, T124A, T125A, M154I, V165I, E198D, V201IB
Meixenberger (2017)86-0019886-00198KM677337None   I72V, M154IB
 86-0047186-00471KM677339None   L45Q, I72V, M154I, V165I, E212A, V249IB
 86-0100886-01008KM677341None   S24G, I72V, M154I, V165IB
 86-0107886-01078KM677342None   I72IV, T125TA, M154I, V165IB
 86-0116686-01166KM677343None   S17SN, I72V, M154I, V165VIB
 86-0119686-01196KM677345None  V151VII72V, M154IB
 86-0126986-01269KM677346None   E10D, I72IV, M154I, N254NK, D256DEB
 86-0147086-01470KM677347None   I72V, I84IV, M154IB
 86-0323286-03232KM677354None   I72V, M154IB
 86-0377486-03774KM677359None   I72V, M154I, V165IB
 86-0412586-04125KM677361None   E10D, I72V, L101I, S119G, T122I, T124TA, M154I, V165VI, I251IVB
 86-0421386-04213KM677362None   I72V, P90S, M154IB
 86-0451686-04516KM677364None   S17N, I72V, T112A, T124A, T125TA, M154I, Q216QHB
 87-0910987-09109KM677374None  T97TAS17SN, P29PS, I72V, F100FY, T125A, M154IB
 88-0177388-01773KM677378None   D64N, I72V, M154IB
 88-0364888-03648KM677380None   M154IB
 88-0444088-04440KM677381None   S17C, T125TA, M154I, V165X, V201VIB
 88-0567788-05677KM677384None   I72V, P90S, M154I, S230NB
 88-0570488-05704KM677385None   E11D, A21T, I72IV, I84V, S119P, T122TI, M154I, Q216HB
 88-0676888-06768KM677389None   K7KQ, V31VI, M50MI, M154I, V201IB
 88-0684988-06849KM677390None   I72V, K111R, T124N, M154I, V165I, I251IMB
 88-0686388-06863KM677391None   A23V, S24G, D25DE, L28X, L45LV, I72IV, M154I, V165I, V201VIB
 89-0118189-01181KM677394None   G4GE, I60IV, M154I, D256EB
 89-0146189-01461KM677398None   K7R, I72IV, V110VG, T125A, M154I, F185FS, V201VI, L234LHB
 89-0201489-02014KM677401None   E10D, L28I, I72V, T122I, T125A, M154I, V165I, V201IB
 89-0201889-02018KM677402None   T122I, T124A, M154I, V165IB
 89-0232689-02326KM677405None  T97TAE11D, S17T, M154I, V165IB
 89-0236289-02362KM677406None   S24SG, M154I, T218I, L234IB
 89-0259089-02590KM677409None   M154I, T218TI, L234VB
 89-0414989-04149KM677414None   S17N, I72IV, T124A, M154I, V201VI, D256DEB
 89-0454189-04541KM677416None  T97TA, F121FIE10D, H12HN, I72V, M154IB
 91-0204691-02046KM677421None   I72V, P90S, M154I, V165I, V201IB
 92-0257492-02574KM677429None   I72V, M154I, V249VIB
 92-0269492-02694KM677430None   E10D, I60M, I72V, S119G, T122I, M154I, V201IB
 92-0282892-02828KM677431None   I72V, L101I, T112TI, S119P, T124N, M154IB
 92-0291492-02914KM677432None   Q9Q*, S24N, G106GE, T124TA, M154I, V165I, V201VIB
 92-0460692-04606KM677440None   R20RK, I72V, M154I, V201IB
 92-0511492-05114KM677443None  V151VIM50R, L101I, M154I, V165I, G193EB
 92-0635392-06353KM677451None   S24N, L101I, M154I, V165I, K211Q, E212AB
 93-0423693-04236KM677456None   E10D, A21T, M154I, V165I, S195CB
 94-0099594-00995KM677461None   I72V, L101I, M154IB
 94-0123894-01238KM677462None   K34R, H51X, M154I, I203MB
 94-0154694-01546KM677466None   M154I, I203MB
 94-0434794-04347KM677471None   S17ST, S24N, I72IV, T124TN, M154I, V165I, K211QB
 94-0628394-06283KM677474None   M154I, I203M, K244RB
 94-0629994-06299KM677475None   E10D, V31M, M50I, L101I, M154I, K211RB
 95-0089695-00896KM677481None   M154I, I203M, K244RB
 95-0555595-05555KM677493None   M154I, E157EK, I203MB
 98-0188498-01884KM677513None   I135IV, M154I, V201I, I203M, Q252QRB
 04-0038404-00384KM677593None   D6E, E10D, N27H, T124N, M154I, V201IB
 04-0041604-00416KM677595None   S17N, I72V, M154I, V201I, K211RB
 04-0054004-00540KM677598None   S17N, L28I, I72V, M154I, K188R, I191L, V201I, Q216NB
 04-0054504-00545KM677600None   I72V, T124N, T125V, M154I, V165I, E198D, V201IB
 04-0065304-00653KM677603None   K42KR, T122I, T124A, M154IB
 05-0033905-00339KM677612None   T122I, T124A, M154IB
 05-0093805-00938KM677625None   E10D, E11D, A21T, M50I, I72V, T112I, T125V, M154I, V201IB
 05-0103605-01036KM677628None   K7R, E10A, S17N, I72V, K111KR, T122TI, M154I, K173RB
 06-0101306-01013KM677664None   V31VI, M50MI, I72V, L74I, S119SR, S123C, V126L, M154I, D232E, D256EB
 07-0039407-00394KM677672None   E11D, S17T, L101I, K111A, M154IB