Integrase Inhibitors

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Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	M154I
Rx	II-naive
IncludeMixtures	No

References	29
Patients	77
Isolates	80

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	INIMajorDRMs	INIMinorDRMs	OtherMut	Subtype
Skinner (1998)	2	ED002		None			D41N, I72V, M154I, K211R	B
Hierholzer (2002)	BK132	BK132	AY173951	None			I72V, M154I	B
	US1	US1	AY173952	None			S17N, I72V, I84V, T124A, M154I, K173R	B
Swanson (2003)	BK132	BK132	AY214056	None			I72V, T125TM, M154I	B
	US1	US1_2	AY214059	None			S17N, I72V, I84V, T124A, M154I, K173R	B
Sierra (2004)	V62	V62	AY536236	None			I72V, T124A, M154I, V165I, F185Y, R187K, S283G	B
Brown (2005)	BB_85US_Ba-L	85US_Ba-L	AY713409	None			V88I, M154I	B
de Sa Filho (2005)	BREPM107	BREPM107	AY771588	None			S17N, V32I, S57N, I60M, I72V, S119T, M154I, V165I, V201I, T206S, L234V, D256E, V281M, S283G	B
de Sa Filho (2006)	BREPM11884	BREPM11884	DQ085868	None			E11D, L101I, M154I, H171Y, V201I, D256E, S283G	B
Sanabani (2006)	02BR006	02BR006	DQ358807	None			L101I, M154I, V201I, A205S, I251L, D256E, S283G	B
Andresen (2007)	PMVL 039	PMVL 039	EF514703	None			S39C, L45V, L101I, M154I, V165I, R187K, K211R, K215N	B
Brennan (2007)	01BAB055	01BAB055	EF150549	None			I72V, S119T, T124A, S153A, M154I, V165I, G193R, V201I, A265V	B
	01BAB063	01BAB063	EF150555	None			I72IV, T124A, M154I, V165I, R187K, V201VI	B
	01BAB034	01BAB034	EF150619	None			E11D, K14R, S17T, M50I, I72V, T124A, M154I, V165I, V201I, T206S, Y227F, L234V, D256E, S283G	B
	01CEB079	01CEB079	EF150626	None			E11D, M50I, I72V, I84L, L101LI, M154I, V165I, V201I, A205S, L234V	B
Lataillade (2007)	03-5187	ML_03-5187	EF472782	None			K7Q, T112TP, T124N, T125A, V126L, M154I, V201I, I220V	B
Buzon (2008)	Pt17	Pt17Y2004	EU883839	None			E10D, M50I, I84V, M154I, V201I, T206S	B
	Pt41	Pt41Y1995	EU883905	None			E10D, T124A, M154I, K211R, D253DE	B
		Pt41Y2005	EU883906	None			E10D, M50I, L101I, M154I, I162IL, H171HL, V201I, K211R	B
Miura (2008)	BEC33	BEC33	EU517866	None			S17N, I72V, T112A, T122I, T124A, M154I, A265V	B
	BEC51	BEC51	EU517876	None			D6DN, V31I, I72IV, T112A, T124N, M154I, I191L	B
	BEC59	BEC59	EU517880	None			E10G, T125A, M154I, N222NH, L234V	B
	BEC71	BEC71	EU517886	None			L101I, T125A, M154I, I162V, V165I, K173R, V176I, F181L, R187K, V201I, N254H, D256E	B
	BEC77	BEC77	EU517887	None			E10V, A21T, I72V, M154I, A265V	B
Brumme (2009)	INT_3493	INT_3493	FJ812944	None			S17SN, V31VIM, I72V, L101LI, M154I, V201VI, T218TS	B
	INT_3522	INT_3522	FJ812973	None			S17N, I72V, K111R, S119T, T124A, M154I, K188KR	B
	INT_3589	INT_3589	FJ813040	None			S17SN, L101I, M154I, K173KR, V176VL	B
	INT_3610	INT_3610	FJ813061	None			L45I, M154I, V201I	B
	INT_3681	INT_3681	FJ813132	None			S17SN, T112V, T124N, M154I, V201VI	B
	INT_3773	INT_3773	FJ813224	None			M50MIT, I72V, A91AG, T122TI, T124TN, T125TAIV, V126VA, M154I	B
	INT_3903	INT_3903	FJ813354	None			E11D, A21T, A23V, L101I, M154I, N222NT	B
	INT_3910	INT_3910	FJ813361	None			A21AT, L45I, L63LI, L101I, M154I, R187K, L242LF	B
	B3506	B3506	GQ371794	None			I72IN, K111KR, M154I, K188KR, R228RG	B
	B3535	B3535	GQ371796	None			E11D, S17N, D25E, L45I, I72V, I84L, L101I, T124TA, M154I, V165I, K188R, K211T, V259I, S283G, D288N	B
	B7521	B7521	GQ371807	None	E138K		E11D, K14R, S24N, I84IV, T125A, M154I, K156N, V201I, K211R	B
	D5513	D5513	GQ371825	None			V31I, T124N, T125A, K136Q, M154I, F185FY, L234V, D253E, R262RK, E287A	B
	F4520	F4520	GQ371871	None			I72V, I84V, K111R, M154I, D167E, V201I	B
	J9520	J9520	GQ371951	None			D25E, K34R, I72V, F100S, L101I, T125A, M154I, V165I, K173KN, V201I, T206S, R262RK, D270E	B
	M1546	M1546	GQ372004	None			K14KR, M50I, L74I, I84IV, M154I, V201I	B
	N5523	N5523	GQ372036	None			S17N, T124N, T125A, M154I, V165I, V201I, R269K	B
	P3502	P3502	GQ372080	None		L68V	S17N, D41N, M50I, P90S, S119R, T124N, M154I, G163E, K211R, D256E	B
	P8578	P8578	GQ372096	None			K7Q, N27G, T124N, M154I, V201I, L234I, R262RK, S283G	B
	V5522	V5522	GQ372209	None		V54I	E10D, M50I, T124A, M154I, Q216N	B
	X3522	X3522	GQ372252	None			S24G, V32I, D41N, I72V, T124N, T125A, K136Q, M154I, V165I, V201I	B
	Y4518	Y4518	GQ372283	None			S17N, V31VIM, I72V, T124N, M154I, Q164QH, V165VI, Y227F, D256E	B
Eshleman (2009)	ARG2982	ARG2982	FJ480322	None			E10D, I72IV, T124TA, M154I, V165I, L234V, D256E, S283G	B
	BrRJ96-002	BrRJ96-002	FJ480324	None			S24N, L28I, M154I, V165I, V201I, I208L, Q216H	B
Garrido (2009)	83	INT-83	GU216930	None			S17N, V31I, M50I, I72V, N117HY, T124A, K127R, M154I, I162KN, R166RK, V201I, D253DE, D279N	B
	87	INT-87	GU216934	None			D3G, G4G*, S17N, L101I, T112V, S119T, T124N, M154I, V201I, D256E, D279DN	B
	261	INT-261	GU217108	None			D6E, E10D, S17T, S119P, T122I, T124N, T125A, M154I	B
Low (2009)	A-6	A-6	FJ786270	None			M154I, V201I	B
	mdr11	mdr11	FJ786396	None			E10K, D25K, E69K, I72V, L101I, K111Q, S119G, T122I, M154I, E157K, V201I, L234V, D256E	B
Nadai (2009)	129473	129473	EU839603	None			I72V, T124A, M154I, I208L, K211R, E212I, Q216H, V260I	B
Passaes (2009)	BR.RJ.FT36	BR.RJ.FT36	HM026765	None			E10D, I60M, M154I, D167E, N254S, S255G, V281M	B
Sichtig (2009)	2473	2473	FJ183513	None			R20K, I72V, L101I, M154I, V165I, I182V, V201I	B
	10-E	10-E	FJ183515	None			K14KR, S17N, R20RK, M22MR, I72V, I113V, S119T, T124A, M154I, V165I, V201I, T206TS, I208IL, T218TS	B
	29-E	29-E	FJ183526	None			M154I, V201I, T218S	B
	4834	4834	FJ183622	None			R20RK, S39ST, I72V, L101I, M154I, G193E	B
	5760	5760	FJ183676	None			K14KR, M154I, V201I, D229E	B
van Hal (2009)	W82	W82	FJ554755	None			E10D, K14R, I72V, S119G, T122I, T125A, M154I, V201I, R284G, Q285R	B
Wang (2009)	F706	F706	FJ469728	None			S24G, D41N, I72V, M154I	B
	L827	L827	FJ469747	None		G163R	E10D, I72V, T125A, M154I, K156N, V201I, D256E	B
	PRLS01	PRLS01	FJ469753	None			S17N, I72V, L101I, K111R, S119P, T124A, T125A, M154I, K211Q, T218I, D232E, D256E	B
	PRLS12	PRLS12	FJ469759	None			D6E, E11D, A21T, I72V, I84V, S119P, T124N, T125A, V126L, M154I	B
	PRLS17	PRLS17	FJ469761	None			Q62R, I84V, T122I, T125A, M154I, K211R, K219N, N222K	B
	SH8183	SH8183	FJ469768	None			E10A, E11D, A21T, I84V, T112R, S119P, T122I, T125A, M154I, L234I	B
Rangel (2010)	N477p	N477p	GU797498	None			L28I, P30A, I72V, L101I, T112A, S119T, T125A, M154I, T206S, K215N, N222K	B
Brenner (2011)	INT10	INT10	HQ207809	None		L74LIM	I60IM, I84M, L101I, M154I, G163A, K173KR, V201I, A205S	B
Rolland (2011)	1399	consensus_1399	JF320012	None			I84V, L101I, T112A, T125A, M154I, V165I, Q177L, F181Y, L234I	B
	1512	consensus_1512	JF320356	None			S17N, M50I, I72V, I84V, P90A, T124A, M154I, V201I, D253E, D256E	B
Sanabani (2011)	BR2025	BR2025	JN692435	None			S17N, V31I, I72V, P90S, T124N, V126L, M154I, V201I, T218S	B
	BR1079	BR1079	JN692462	None			S17N, L28I, I72V, T124A, M154I, T206S, Y227F, L234H, D256E, R284G	B
Brockman (2012)	AEHIV56	AEHIV56	JQ080140	None			L45I, M154I, V201I	B
Iamarino (2012)	BF.BR.1470	BF.BR.1470	JN234040	None			E11D, S17N, M50L, I72V, I84M, I113V, S119T, T124N, T125A, M154I, V165I, V201I, L234V, D256E, S283G	B
	BF.BR.1027	BF.BR.1027	JN234054	None			S17N, A21S, A23V, D25E, V31I, E69K, G70E, I113V, T124A, T125A, M154I, E157K, D167E, T206S, D253E	B
	BF.BR.1038	BF.BR.1038	JN234056	None		V151I	S17N, A21S, A23V, V31I, L101I, T112I, M154I, V201I, T206S	B
	B.BR.1009	B.BR.1009	JN234114	None			S24G, D25E, L45I, S119G, T122I, T124N, T125A, M154I, V165I, K211R, I220V	B
	B.BR.1039	B.BR.1039	JN234120	None			S17N, I72V, T124A, M154I, V165I, V201I, D229E, S230N, S283G	B
	B.BR.1546	B.BR.1546	JN234179	None			K7R, I72V, T124A, M154I, V201I	B
Rolland (2012)	AA040a_WG13	AA040a_WG13	JX447158	None	E138K	T97A	G70E, L101I, S119R, T124N, T125S, M154I, K211R	B

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