<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation M154I
Rx >=1 INI
IncludeMixtures No
References 11
Patients 40
Isolates 43
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Baldanti (2009)PV10PV10GU350735RAL52  E10D, S24N, L101I, M154I, G163S, V165I, K240TB
 PV3PV3GU350736RAL13G140S, Q148H, N155H S17N, I72V, T124A, M154I, E170A, V201IB
Sichtig (2009)Pt085255FJ183703RAL76N155HV151VI, G163GRT112I, T124N, M154I, V201I, D232DNB
Hatano (2010)4Virus15GU121691RAL Y143RT97AK7R, S17N, V31I, L101I, T112A, T125A, M154I, V201IB
  Virus16GU121692RAL Y143RT97A, G163GRK7R, S17N, V31I, L101I, T112A, S119T, T125A, M154I, V201VIB
Blanco (2011)ACM_09BLACM_09BL RAL N155H E10D, S119G, T122I, T124N, T125A, M154I, K211RB
 GCC_10BLGCC_10BL RAL N155HV151IA21S, M22I, A23V, S24G, I84V, M154I, V165I, V201I, D232NB
Canducci (2011)Pt8Pt8w12JN163901RAL13Y143R, N155H S17N, A49S, I72V, T124A, M154I, E170A, V201I, G277RB
Fransen (2012)pt2pt2 RAL Y143YR, N155NHQ95QK, V151I, G163GRE10D, V31I, L101I, M154I, V165I, V201IB
Garrido (2012)BAA295911BAA295911JQ716900RAL52  G4GE, L101LI, M154I, I220VB
Molina (2012)41324132_2 EVG83  S39SN, P90PS, L101I, M154I, V201I, T210TI, K215N, L234LF, L242LF, D279GB
 40424042_2 EVG48  M22MV, L101I, M154I, V165I, H171L, K211RB
  4042_3 EVG106  A91AT, L101I, M154I, V165I, H171L, K211R, S283SGB
 40544054_2 RAL82 V151VIS17SN, L101LI, M154I, I203IVB
 34653465_2 EVG12  E10D, A38AV, I84IV, T124N, T125A, I135IV, I141IT, M154I, D202DG, D207DNB
  3465_3 EVG36  E10D, T124N, T125A, I135IV, M154I, V201VIB
 33523352_2 RAL32  L101I, V110VI, T124A, T125A, M154I, H171Y, R187K, T206S, K211RB
 30603060_2 EVG64T66I, Q148QR T112A, T125A, V126L, M154I, L234IB
 34213421_2 RAL91  S24G, L101I, T124A, S153A, M154I, I200M, V201I, Q216H, Q221R, D256EB
Sax (2012)66676667_2 EVG48E92Q M50I, T125A, I135V, M154I, I162V, V201I, K215N, L234IB
de Souza Cavalcanti (2014)BRSP73BRSP73 RAL N155H D25E, V31I, M154I, S230NB
 BRSP54BRSP54 RAL   S17N, I72V, I84M, N117T, T124A, T125A, M154I, V201I, Q221NB
 BRSP39BRSP39 RAL G140S, Q148H A23V, T125A, M154I, A169T, R187K, K188R, V201IB
 BRSP126BRSP126 RAL   S17N, I72V, T124A, M154I, V165I, V201I, Y227F, L234V, D256E, S283GB
Hurt (2014)IN_2223IN_2223 RAL E138EK, G140S, Q148H K14R, S17C, M50I, I72V, T125A, I135V, M154I, R187RK, T206S, K219N, N222K, D286NB
 IN_1525IN_1525 RAL G140S, Q148H E11D, S24N, D25E, V31I, I72V, L101IV, S119P, T122I, T124A, M154I, V165I, T218S, D253EB
 IN_265IN_265 RAL E138K, G140S, Q148H K14R, V31I, S39C, M50I, L101I, T124A, M154I, V201I, K211Q, S230N, L234I, D253EB
 IN_2513IN_2513 RAL E138K, G140S, Q148H S17N, T124N, T125A, K127KR, M154I, V165IB
 IN_1016IN_1016 RAL G140GS, Q148H K14R, I84V, T112A, I113IV, T125A, K136KR, M154I, S230N, L234VB
 IN_3256IN_3256 RAL E138K, G140S, Q148H R20RK, S39C, M50MT, I84IL, L101I, K136N, M154I, D167E, V201I, K215KN, K244KRB
 IN_708IN_708 RAL G140S, Q148HL74LMS17N, I72V, I84L, T97TS, L101I, T112I, T124A, M154I, V165I, L234VB
 IN_156IN_156 RAL E138EK, G140S, Q148H K14KR, S17N, T124N, T125AV, M154I, V165IB
 IN_3244IN_3244 RAL N155H D6DE, S17N, D25E, K34R, M50MI, L101LI, T124N, T125A, I135V, M154I, V201VI, K219N, N222K, D286DNB
 IN_3328IN_3328 RAL G140S, Q148H S17N, D25E, I84V, L101I, T124S, T125M, I135V, M154I, D286NB
 IN_369IN_369 RAL N155HV151IE10D, I72V, I84V, I135V, M154I, V201I, D232NB
 IN_1915IN_1915 RAL E138A, G140S, Q148H T124A, M154I, G193E, V201I, I208L, D278N, S283GB
 IN_1128IN_1128 RAL E92EQ S39SN, M50MI, T125A, I135V, M154I, I162V, V201I, K215N, L234IB
 IN_803IN_803 RAL N155HV151VI, G163GRE10ED, I72V, L101LI, M154I, V165I, V201I, T206TS, I208IL, K211KR, E212ALSV, D232DN, L234IB
 IN_237IN_237 RAL G140S, Q148H E13D, K14R, V31VI, T124N, T125TAIV, V126VL, M154I, V201I, K211R, I217IV, D232DN, D256EB
 IN_1097IN_1097 RAL E138EA, G140S, Q148H S17N, E87D, T112A, T124N, T125A, M154I, V201VIB
 IN_396IN_396 RAL G140S, Q148H I72V, Y99F, T124N, M154I, R187K, V201I, K211R, S230NB
 IN_553IN_553 RAL G140S, Q148H S17N, M50ML, E87D, T112TA, T124N, T125A, M154I, V201VIB
 IN_1250IN_1250 RAL N155NH S17N, T124N, M154I, V201IB