<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation Q148R
Rx >=1 INI
IncludeMixtures No
References 14
Patients 53
Isolates 61
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Charpentier (2008)Pt1Pt1-W4 RAL4Q148R E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
  Pt1-W8 RAL8Q148R E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, V259I, D278EB
 Pt3Pt3-W15 RAL15G140S, Q148R I72V, T124TA, K156N, D167E, S283G, D288NB
Malet (2008)1bH-SH1-W8FJ538990RAL8Q148R, N155H E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
Baldanti (2009)PV2PV2GU350733RAL51Q148R E10D, I72V, L101I, K156N, L234IB
Canducci (2009)pt6pt6W8EU908749RAL8Q148R L101I, K156N, I208LB
  pt6W12EU908750RAL13G140S, Q148R D3N, L101I, K156N, I208LB
Garrido (2009)Pt01Pt01 RAL G140A, Q148R K14R, S24G, D25E, L45I, I113V, T124N, T125A, E157Q, K160S, V165VI, I220L, Y227F, L234V, D256EB
 Pt02Pt02 RAL G140S, Q148R E11D, V31VI, V32I, V37I, L101I, V201I, D232E, D256EB
Hatano (2010)17Virus99GU121775EVG E138K, S147G, Q148R K7KR, I72V, V79VI, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus100GU121776EVG E138K, S147G, Q148RV54VIK7KR, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus103GU121779EVG E138K, S147G, Q148RV54VIK7KR, E35EQ, I72IV, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus20GU121696EVG E138K, S147G, Q148RV54IK7KR, E35EK, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
Brenner (2011)1037910379_1HQ423444RAL E138EA, G140A, Q148R E10EQ, E11D, S24N, D25E, M50I, K111T, I203M, L234LV, V259VIB
Canducci (2011)Pt1Pt1W8BJN163875RAL8E138K, Q148R L101I, K156N, I208LB
  Pt1w12JN163876RAL13G140S, Q148R L101I, K156N, I208LB
 Pt7Pt716JN163897RAL13G140S, Q148R T125V, K156N, I208M, D256EB
  Pt7W40JN163898RAL39G140A, Q148RG163RE10G, K14R, V79I, T125V, K156N, I208M, D232N, D256EB
 Pt10Pt10w20JN163905RAL21Q148R S24N, L74I, L101I, T125A, V201I, Q216HB
Armenia (2012)PT_84PT_84_MO_4JN544109RAL G140S, Q148R D6S, K7E, S17N, I72V, V201I, D256EB
DeJesus (2012)73597359_2 EVG20Q148R E10D, I72IV, L101I, S119P, T122I, T124N, T125S, V165VI, T218SB
 72997299_2 EVG32G140C, Q148R K14R, S17N, K34R, G59E, S119P, T124N, T125A, H183HP, V201I, S230N, D256EB
Garrido (2012)BAA295958BAA295958JQ716866RAL52G140A, Q148R V31I, D41N, L101I, V201I, T206S, I268L, R269KB
 BAA295891BAA295891JQ716892RAL52G140A, Q148R K14R, S24G, D25E, L45I, I113V, T124N, T125A, E157Q, K160S, V165VI, I220L, Y227F, L234V, D256EB
Souza Cavalcanti (2012)BRSPBR10SP296JQ797733RAL130E138K, G140C, Q148RV54IE11D, V31I, V32I, V37I, D41N, V79I, L101I, T125A, K136Q, V201I, T206S, L234V, D270EB
de Souza Cavalcanti (2014)BRSP446BRSP446 RAL Q148R L101I, K111T, S119P, T122I, T124A, V201I, T206SB
 BRSP461BRSP461 RAL G140A, Q148R K14R, S17N, V31I, V32VG, S39R, V79I, L101I, S119G, T122I, T125A, P142SB
 BRSP17BRSP17 RAL G140A, Q148R E10D, V31I, M50I, V79I, L101I, K111T, S119T, T124Q, T125A, I135V, I203M, I208L, L234LV, V259VIB
 BRSP318BRSP318 RAL E138K, G140C, Q148RV54I, L74MD6T, K7E, K14R, V31I, I72V, V79I, S119P, K156KN, E157Q, K160KT, V201I, T218S, R284GB
 BRSP296BRSP296 RAL E138K, G140C, Q148RV54IE11D, V31I, V32I, V37I, D41N, V79I, L101I, T125A, K136Q, V201I, T206S, L234V, D270EB
 BRSP239BRSP239 RAL E138K, S147G, Q148RV151I, G163RK14R, L74I, V75M, V79I, S119P, T122I, T124A, T125A, K156N, V201I, T218I, L234V, D256E, S283G, R284GB
Hurt (2014)IN_1622IN_1622 RAL E138K, S147G, Q148RQ95KK14R, R20K, V32I, L45V, L101I, K103R, T124A, G163E, V201I, K215N, N222K, D270HB
 IN_1151IN_1151 RAL E138EK, Q148R K14R, S17N, K34R, M50V, I72V, T124A, V201I, S283G, R284RGB
 IN_65IN_65 RAL E138K, S147G, Q148R K7R, K14R, K71N, V79VI, A91AT, S119R, T124N, T125A, K156N, G193E, V201I, N222K, S230N, L234VB
 IN_1725IN_1725 RAL G140S, Q148R A23V, I72V, K211QB
 IN_543IN_543 RAL E138K, Q148RA128TS17N, I72V, P90S, L101I, K156N, V201I, I220VB
 IN_612IN_612 RAL E138A, G140A, Q148R K14R, L101I, S119P, T124A, K136T, P142T, I203M, I208M, T218S, Y227F, L234I, D256EB
 IN_617IN_617 RAL G140S, Q148RL74IME11D, L28I, V37I, I72V, L101I, T112K, S119P, T122I, T124A, T125A, D167E, K211Q, Q216QR, L234V, A265VB
 IN_2222IN_2222 RAL E138K, S147G, Q148RG163RM50I, V79I, Y99F, L101I, M154MI, K156N, K211KRB
 IN_2095IN_2095 RAL E138K, S147G, Q148RV54VI, V151VIV31I, A49P, L74I, V79I, L101I, T124TA, I141V, I203IM, I204IVB
 IN_81IN_81 RAL G140S, Q148RL74MS17SN, I72V, F100S, L101I, K111T, S119P, T124A, T125A, E157Q, K160KINB
 IN_1542IN_1542 RAL E138EK, Q148R K46KQ, I72V, F181L, V201I, A265VB
 IN_524IN_524 RAL G140A, Q148R D6E, E10D, E11D, V31I, M50T, V201I, T206S, L234I, R269KB
 IN_1723IN_1723 RAL E138K, G140C, Q148RV54IV79I, T124A, K136N, V201VI, I208M, L234H, V259I, R284GB
 IN_1200IN_1200 RAL G140S, Q148R S17N, V31I, G106A, T125A, V126L, K156N, G163T, K173R, V201I, D253DN, D256EB
 IN_3306IN_3306 RAL G140S, Q148R S17N, V31I, L63I, L74I, L101I, T112TA, I113IL, K156N, Q216H, L234LV, D256EB
 IN_2457IN_2457 RAL G140S, Q148RG163KE11D, S24N, L101I, K111KR, T112A, T125A, K156NB
 IN_1638IN_1638 RAL E138K, S147G, Q148RQ95KK14R, R20K, V32I, L45V, L101I, K103R, T124A, G163E, V201I, K215N, N222K, D270HB
 IN_221IN_221 RAL G140A, Q148R E11D, V31I, V79I, T125V, E152EK, L158I, L234V, D286NB
 IN_1139IN_1139 RAL G140S, Q148RG163RK14R, V31I, L45I, I72V, K160N, D167E, T206S, T218S, D256EB
 IN_995IN_995 RAL G140C, Q148RL74M, E138GS17N, L101I, T124A, T125A, D167E, D253EB
 IN_1439IN_1439 RAL E138K, Q148R S17N, L28I, M50I, I72V, T124A, K156N, I162V, I208L, D256EB
 IN_1121IN_1121 RAL E138K, G140S, Q148RG163GRE11ED, K14KR, S39SN, L45LI, T112A, T124A, T125A, K136E, K156N, G193R, T206S, I208L, K211KQ, E212A, T218S, D232DN, L234I, A265AVB
 IN_2511IN_2511 RAL G140S, Q148R V31I, M50I, L101I, T124N, D167E, T206S, Y227F, S230N, D256E, A265VB
 IN_746IN_746 RAL E138K, Q148R E13ED, L45AV, K111R, T112TI, T124A, T125A, V126L, K211R, S230N, R284RGB
 IN_2739IN_2739 RAL G140S, Q148RG163RL63V, I72V, L74I, T112TI, T124A, K156N, I182V, V201I, N254Q, V259IB
 IN_849IN_849 RAL G140A, Q148R E11D, K111T, T124N, D167E, V201VI, I203IMB
 IN_994IN_994 RAL G140S, Q148R K14R, V31I, K42KR, M50T, L63LV, L74I, K111T, T206S, D256DE, V259VIB
 IN_2925IN_2925 RAL E138K, Q148RV151VIM50I, I72V, L101I, T112V, T124A, I135V, K160KN, D167E, V201I, R284GB
 IN_442IN_442 RAL G140GS, Q148R K14R, I72V, T124N, T125AV, V201I, D232E, D256E, A265VB
 IN_727IN_727 RAL S147G, Q148RH114YE11D, V31VIM, I113V, T124N, T125V, L158V, S195TB