<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation Q148H
Rx >=1 INI
IncludeMixtures No
References 13
Patients 32
Isolates 53
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Malet (2008)1aSH1-W12FJ538986RAL13G140S, Q148H K7Q, E11D, V31I, M50L, I72V, L101I, T124A, I135V, I200L, V201I, I220LB
 1bH-SH1-W16FJ538991RAL15G140S, Q148H E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
 1cSH2-W10FJ538988RAL11G140S, Q148H S17N, L28I, S39C, S119P, T122I, T124A, T125AB
 HSH2H-SH2-W22FJ538994RAL22G140S, Q148HG163RS17N, R20K, L28I, S39C, G70R, T124A, T125A, V201I, I208LB
Baldanti (2009)PV5PV5GU350729RAL26G140S, Q148H E13D, L101I, M154L, V165I, A196P, V201I, I208L, L234V, D256EB
 PV3PV3GU350736RAL13G140S, Q148H, N155H S17N, I72V, T124A, M154I, E170A, V201IB
Canducci (2009)pt6pt6W36EU908753RAL39G140S, Q148HT97AL101I, S119R, K156N, I208LB
  pt6w48EU908754RAL52E138A, G140S, Y143H, Q148H L101I, S119R, K156N, I208L, R224RGB
 pt3pt3w24EU908758RAL26G140S, Q148HV54IV31I, I113V, T124A, T125A, V201I, K215NB
Sichtig (2009)Pt025068FJ183700RAL35G140S, Q148HG163KS17N, R20K, L28I, S39C, L45V, I113V, T124N, T125A, V201I, V259IB
  5864FJ183701RAL79G140S, Q148HG163EKQS17N, R20K, L28I, S39C, L45V, I113L, T124N, T125A, V201IB
Wittkop (2009)11_M6GU358379RAL25G140S, Q148H E10D, R20K, V32I, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222KB
  1_M9GU358380RAL39E138EA, G140S, Q148H E10D, R20K, V32I, L45LI, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K, V259VIB
  1_M12GU358381RAL52E138EA, G140S, Q148H E10D, R20K, V32VI, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K, V259VIB
 55_M1GU358392RAL4G140S, Q148H E11D, E13D, V31I, M50I, S57G, I89V, S119P, T122I, T124A, T206S, S255N, D256E, S283GB
  5_M3GU358393RAL12G140S, Q148H E11D, E13D, V31I, M50I, S57G, S119P, T122I, T124A, T206S, S255N, D256E, S283GB
  5_M6GU358394RAL25G140S, Q148H E11D, E13D, V31I, M50I, S57G, L63LI, S119P, T122I, T124A, T206S, T210TS, S255N, D256E, S283GB
  5_M9GU358395RAL39G140S, Q148HL74LME11D, E13D, V31I, K34KR, M50I, S57G, L63I, S119P, T122I, T124A, T206S, I208IL, S255N, D256E, S283GB
 22_M6GU358401RAL25G140S, Q148H D3DN, E10ED, R20K, K160R, V201IB
  2_M9GU358402RAL39G140S, Q148H D3DN, R20K, K160R, V201IB
Hatano (2010)1Virus4GU121680RAL G140S, Q148H S17N, S24D, S39C, L45LQ, L101I, T124N, D167E, V201I, E212A, R284G, D286NB
  Virus5GU121681RAL G140S, Q148H S17N, S24D, S39C, L45LQ, L101I, T124N, D167E, V201I, E212A, R284G, D286NB
 2Virus114GU121790RAL G140S, Q148H L63I, I73V, L74I, E96D, L101I, T112I, I208L, D232E, L234LFB
  Virus8GU121684RAL G140S, Q148H L63I, I73V, L74I, E96D, L101I, T112I, I208L, D232EB
 5Virus27GU121703RAL G140S, Q148H S17N, I72V, L101I, K156N, V201I, D207DG, I208LB
 7Virus129GU121805RAL G140S, Q148HV151ID25E, I72V, K211R, K215NB
Blanco (2011)CA8070CA124205 RAL29G140S, Q148H K14R, L101I, T112A, G193E, D279GB
  CA124204 RAL85G140S, Y143YH, Q148H K14R, L63I, L101I, T112A, G193E, D279GB
  CA128615 RAL113G140S, Q148H K14R, Q44QH, L63I, L101I, T112A, G193E, D229E, D279GB
  CA153556 RAL161G140S, Q148H K14R, L63I, L101I, T112AS, G193E, V201VI, D229E, D279GB
 CLD_01_BCLD_01_B RAL G140S, Q148H E11D, S24G, L28I, L101I, I113L, T122I, T124A, V201VIB
 DCR_02BLDCR_02BL RAL G140S, Q148H A23V, V31I, T125V, D232E, A265VB
 JRM_04BLJRM_04BL RAL G140S, Q148H K14R, V32I, S39C, L101I, T112I, I135V, V201I, T206S, T218S, I220V, K240R, C280S, D286NB
Brenner (2011)INT21INT21HQ207822RAL G140S, Q148H L45V, L101I, E157Q, K160Q, K215N, D232N, D256EB
 INT9INT9_1HQ207832RAL G140GS, Q148H V31I, I72V, T124N, V126M, I135V, A265VB
 092807.021092807.021HQ423434RAL G140S, Q148H E11D, M50I, G193E, V201I, D232DN, D256E, D286DNB
 093107.007093107.007HQ423436RAL G140S, Q148HG163EKV31I, L45I, L101I, S119G, T122I, E157Q, K160Q, V176L, V201I, I208M, K215N, L234I, D253H, D256EB
 090808.001090808.001HQ423438RAL G140S, Q148H E11D, V31VIM, L101I, K111AS, T125TA, I135V, K156N, R187K, V201I, I220IV, S283SGB
 1080610806HQ423445RAL G140S, Q148H E11D, S24N, D25E, M50I, K111T, T112TK, I203MB
Canducci (2011)Pt1Pt1W24JN163878RAL26G140S, Q148HT97AL101I, S119R, K156N, I161F, I208LB
  Pt1W48JN163879RAL43E138A, G140S, Y143H, Q148H L101I, S119R, K156N, I208L, G277RB
 Pt4Pt4W24JN163889RAL26G140S, Q148HV54IV31I, I113V, T124A, T125A, V201I, K215N, G277CB
 Pt7Pt7W64JN163899RAL65G140S, Q148HG163RK14R, V79I, T112A, T125V, K156N, I208M, D256EB
 Pt10Pt10w28JN163906RAL30G140S, Q148H S24N, L101I, T125A, V201I, Q216HB
  Pt10w32JN163907RAL35G140S, Q148H S24N, D41N, L74I, A91T, L101I, T125A, V201I, Q216H, N254SB
Armenia (2012)PT_27PT_27_MO_10JN544092RAL G140S, Q148H E11D, V32I, D41N, A91AV, L101I, K111T, N222HB
Garrido (2012)BAA295893BAA295893JQ716870RAL52G140S, Q148H E11D, S24N, V31I, T112IM, T206S, I208L, D253DEB
 BAA295889BAA295889JQ716890RAL52G140S, Q148H D6E, K14R, S17SN, V31I, L101I, K111KE, A128AV, I135V, G163Q, G193E, V201I, D256EB
Lee (2012)318041193A.8JQ666905RAL28G140S, Q148H S17N, S24D, S39C, L45LQ, L101I, T124N, D167E, V201I, E212A, R284G, D286NB
Parczewski (2012)103103_42KC409138RAL84G140S, Q148H E11D, R20K, G70D, I73IV, L101I, S119R, T124N, G193E, S195T, T206S, T218TS, D270NB
  103_43KC409139RAL96G140S, Q148H E11D, R20K, G70D, L101I, S119R, T124N, G193E, S195T, T206S, T218TS, D270NB
  103_46KC409140RAL145G140S, Q148H E11D, R20K, G70D, L101I, S119R, T124N, T125TS, G193E, S195T, T206S, T218TS, D270NB
  103_49KC409141RAL180G140S, Q148H E11D, R20K, G70D, K71KR, L101I, S119R, T124N, T125TS, G193E, S195T, T206S, T218S, D270NB