Integrase Inhibitors

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Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	Y143R
Rx	>=1 INI
IncludeMixtures	No

References	11
Patients	20
Isolates	28

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	Wks	INIMajorDRMs	INIMinorDRMs	OtherMut	Subtype
Canducci (2009)	pt2	pt2w24	EU908741	RAL	26	Y143R		S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E	B
	pt1	pt1w24	EU908745	RAL	26	Y143R		S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H	B
		pt1w48	EU908746	RAL	39	Y143R		S17SN, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H	B
Delelis (2009)	Pt1	Pt1		RAL	48	Y143R		V32I, S39C, K111R, T124N, T125A, G193E, N254K	B
	Pt2	Pt2		RAL	42	Y143R		A205S, I208L, K211Q, E212A	B
	Pt3	Pt3		RAL	16	Y143R		I113V, T124NS, T125A, T206S, I220L, Y227F	B
Garrido (2009)	Pt03	Pt03		RAL		Y143R	T97A	H12HN, V31I, K111T, S119T, T125A, V126L, I135V, P142A, I203M, I208L, D256E	B
Sichtig (2009)	Pt01	4786	FJ183692	RAL	47	Y143R	L74M, T97A	E11D, R20K, V31I, H51HR, S119G, T122I, T125A, V201I, K215N	B
	Pt10	5150	FJ183702	RAL	106	Y143R	L74M, T97A, E138D	S17N, M22I, A23V, L28I, L45V, L101I, S119T, T218TS, L234LV, D256E, I268M	B
Hatano (2010)	4	Virus15	GU121691	RAL		Y143R	T97A	K7R, S17N, V31I, L101I, T112A, T125A, M154I, V201I	B
		Virus16	GU121692	RAL		Y143R	T97A, G163GR	K7R, S17N, V31I, L101I, T112A, S119T, T125A, M154I, V201VI	B
	9	Virus49	GU121725	RAL		E92EQ, Y143R	T97TA	S17N, V31I, L101I, T124A, A169AG, L234I	B
Blanco (2011)	JGG_03BL	JGG_03BL		RAL		Y143R	L74M, E138D	V31I, T125V, D232E	B
Canducci (2011)	Pt2	Pt2W56	JN163884	RAL	55	Y143R	T97A	L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G277R	B
	Pt3	Pt3W24	JN163887	RAL	26	Y143R		S17N, S24N, I113V, S119T, T124A, T125A, V165I, V201I, T206S, E212K, Q216H	B
	Pt6	Pt6W24	JN163894	RAL	19	Y143R		S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E, G277C	B
		Pt6W32	JN163895	RAL	28	Y143R	T97A	S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E	B
	Pt8	Pt8w12	JN163901	RAL	13	Y143R, N155H		S17N, A49S, I72V, T124A, M154I, E170A, V201I, G277R	B
Armenia (2012)	PT_12	PT_12_MO_1	JN544085	RAL		Y143R	T97A	L101I, S283G, D286DN	B
		PT_12_MO_3	JN544086	RAL		Y143R	T97A	L101I, S283G, D286DN	B
		PT_12_MO_7	JN544087	RAL		Y143R	T97A	L101I, T112TA, S119ST, S283G	B
		PT_12_MO_9	JN544088	RAL		Y143R	T97A	D3DN, D25DE, L101I, T112TA, S119ST, S283G	B
Garrido (2012)	BAA295956	BAA295956	JQ716865	RAL	52	Y143R	L74M	K7R, V31I, L101I, T112I, T125V, K219N, N222K	B
	BAA295870	BAA295870	JQ716888	RAL	52	Y143R	T97TA, V151VI	S17N, V31I, M50T, I72V, V75VI, T124A, K156N, T206S, I220IV, D232DN, D256E	B
Souza Cavalcanti (2012)	BRSP	BR11SP363B	JQ797725	RAL	135	Y143R	T97A	E11D, E13X, K14R, S24D, L28I, S39C, K42KR, L74I, S119P, Q164K, R187K, V201I, D232E, L234I	B
de Souza Cavalcanti (2014)	BRSP222	BRSP222		RAL		Y143R	L74M, T97A, E138D	E10D, V31I, M50I, L101I, T112V, S119P, T122I, T124N, T125A, I135V, E157Q, I203M, I208L, T218S, I220L, D253V	B
	BRSP358	BRSP358		RAL		Y143R		S17N, L28I, P30A, I72IV, T112A, K211R	B
	BRSP75	BRSP75		RAL		Y143R		E11D, S24N, V31I, T112TA, I113IV, S119T, T124N, T125V, I203IM, K219N, I220L, N222K	B

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