Integrase Inhibitors

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Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	Y143R
Rx	>=1 INI
IncludeMixtures	No

References	12
Patients	59
Isolates	67

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	Wks	INIMajorDRMs	INIMinorDRMs	OtherMut	Subtype
Canducci (2009)	pt2	pt2w24	EU908741	RAL	26	Y143R		S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E	B
	pt1	pt1w24	EU908745	RAL	26	Y143R		S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H	B
		pt1w48	EU908746	RAL	39	Y143R		S17SN, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H	B
Delelis (2009)	Pt1	Pt1		RAL	48	Y143R		V32I, S39C, K111R, T124N, T125A, G193E, N254K	B
	Pt2	Pt2		RAL	42	Y143R		A205S, I208L, K211Q, E212A	B
	Pt3	Pt3		RAL	16	Y143R		I113V, T124NS, T125A, T206S, I220L, Y227F	B
Garrido (2009)	Pt03	Pt03		RAL		Y143R	T97A	H12HN, V31I, K111T, S119T, T125A, V126L, I135V, P142A, I203M, I208L, D256E	B
Sichtig (2009)	Pt01	4786	FJ183692	RAL	47	Y143R	L74M, T97A	E11D, R20K, V31I, H51HR, S119G, T122I, T125A, V201I, K215N	B
	Pt10	5150	FJ183702	RAL	106	Y143R	L74M, T97A, E138D	S17N, M22I, A23V, L28I, L45V, L101I, S119T, T218TS, L234LV, D256E, I268M	B
Hatano (2010)	4	Virus15	GU121691	RAL		Y143R	T97A	K7R, S17N, V31I, L101I, T112A, T125A, M154I, V201I	B
		Virus16	GU121692	RAL		Y143R	T97A, G163GR	K7R, S17N, V31I, L101I, T112A, S119T, T125A, M154I, V201VI	B
	9	Virus49	GU121725	RAL		E92EQ, Y143R	T97TA	S17N, V31I, L101I, T124A, A169AG, L234I	B
Blanco (2011)	JGG_03BL	JGG_03BL		RAL		Y143R	L74M, E138D	V31I, T125V, D232E	B
Canducci (2011)	Pt2	Pt2W56	JN163884	RAL	55	Y143R	T97A	L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G277R	B
	Pt3	Pt3W24	JN163887	RAL	26	Y143R		S17N, S24N, I113V, S119T, T124A, T125A, V165I, V201I, T206S, E212K, Q216H	B
	Pt6	Pt6W24	JN163894	RAL	19	Y143R		S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E, G277C	B
		Pt6W32	JN163895	RAL	28	Y143R	T97A	S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E	B
	Pt8	Pt8w12	JN163901	RAL	13	Y143R, N155H		S17N, A49S, I72V, T124A, M154I, E170A, V201I, G277R	B
Armenia (2012)	PT_12	PT_12_MO_1	JN544085	RAL		Y143R	T97A	L101I, S283G, D286DN	B
		PT_12_MO_3	JN544086	RAL		Y143R	T97A	L101I, S283G, D286DN	B
		PT_12_MO_7	JN544087	RAL		Y143R	T97A	L101I, T112TA, S119ST, S283G	B
		PT_12_MO_9	JN544088	RAL		Y143R	T97A	D3DN, D25DE, L101I, T112TA, S119ST, S283G	B
Garrido (2012)	BAA295956	BAA295956	JQ716865	RAL	52	Y143R	L74M	K7R, V31I, L101I, T112I, T125V, K219N, N222K	B
	BAA295870	BAA295870	JQ716888	RAL	52	Y143R	T97TA, V151VI	S17N, V31I, M50T, I72V, V75VI, T124A, K156N, T206S, I220IV, D232DN, D256E	B
Souza Cavalcanti (2012)	BRSP	BR11SP363B	JQ797725	RAL	135	Y143R	T97A	E11D, E13X, K14R, S24D, L28I, S39C, K42KR, L74I, S119P, Q164K, R187K, V201I, D232E, L234I	B
de Souza Cavalcanti (2014)	BRSP222	BRSP222		RAL		Y143R	L74M, T97A, E138D	E10D, V31I, M50I, L101I, T112V, S119P, T122I, T124N, T125A, I135V, E157Q, I203M, I208L, T218S, I220L, D253V	B
	BRSP358	BRSP358		RAL		Y143R		S17N, L28I, P30A, I72IV, T112A, K211R	B
	BRSP75	BRSP75		RAL		Y143R		E11D, S24N, V31I, T112TA, I113IV, S119T, T124N, T125V, I203IM, K219N, I220L, N222K	B
Hurt (2014)	IN_954	IN_954		RAL		Y143R	L74M, Q95K, T97A	D6E, E10D, S17T, A23V, A91T, L101I, S119P, T122I, T124A, T125A	B
	IN_819	IN_819		RAL		Y143R	G163R	V31I, I72V, V75M, T206S, S230N	B
	IN_1881	IN_1881		RAL		Y143R	T97A	V32I, D41N, I72V, V126M, T206S	B
	IN_1169	IN_1169		RAL		Y143R	L74M	E11D, S24N, V31I, L101I, T112A, S119ST, E157EQ, K160KI, V201I, T218L, K219Q, L234I	B
	IN_1256	IN_1256		RAL		Y143R	T97TA	E11D, V31I, M50I, K111T, S119SG, T122I, T124S, V201I	B
	IN_800	IN_800		RAL		Y143R	L74M, T97A	S17N, S119T, E157Q, K160Q, V201I, D256E, R284G	B
	IN_212	IN_212		RAL		Y143R	L74M, T97A	S17N, R20K, V31I, T112S, I113V, S119ST, T124S, T125A, E157Q, K160Q, V201I, K211R, R284G	B
	IN_1642	IN_1642		RAL		Y143R	L74M, T97A	S17N, L101I, S119G, T122I, T124A, T125A, L234V, V259I	B
	IN_2840	IN_2840		RAL		Y143R		Y15YF, S17N, N18NH, L45I, M50I, L101I, K111KR, T112R, T124A, T125A, K156N, V201I, D256E	B
	IN_1518	IN_1518		RAL		Y143R	T97A	D6E, S17N, V31I, L101I, S119T, T124TN, T206S, D232E	B
	IN_848	IN_848		RAL		Y143R	L74M	S17N, V31VI, L63LI, I72N, L101I, T112I, S119P, V201I, D256E, V259VI, R284RG	B
	IN_3286	IN_3286		RAL		Y143R		S17N, L45V, I72V, I113V, S119P, T124A, V150VA, V201I, K211Q, T218S, D256E, D270N	B
	IN_3316	IN_3316		RAL		Y143R	L74LM, T97A	M22I, L28M, V31VI, V32I, I60IM, L101I, S119P, T122TI, T124N, G163V, Q216N, Q221R	B
	IN_1770	IN_1770		RAL		Y143R		D25E, V31I, M50MI, L74I, K111KR, S119T, T125A, G163Q, V201VI, T218S	B
	IN_984	IN_984		RAL		Y143R		S17N, P30S, M50I, I72V, T124A, T125A, T206S, D253E, S255K, S283G	B
	IN_1789	IN_1789		RAL		Y143R	T97A, G163R	S24N, S119P, T125A, I135V, T206S, T210I, S283G	B
	IN_2021	IN_2021		RAL		Y143R	T97A	V31I, I60M, L74I, T112I, T124A, T125A, V126M, E157Q, K160Q, F181L, T206S, N254Q	B
	IN_214	IN_214		RAL		Y143R	L74M, Q95QK, T97A	E10D, V31I, L101I, T112A, S119T, T124A, T125A, I135V	B
	IN_1321	IN_1321		RAL		Y143R	L74IM, T97A	K14KR, S17N, T112A, S119T, T124A, T125A, A128PS, V201I	B
	IN_266	IN_266		RAL		Y143R	L68V, L74M, T97A	V31I, L101I, S119T, G163Q, F181L, T206S	B
	IN_1599	IN_1599		RAL		Y143R	L74M, Q95QK, T97A	E11D, V31I, I72V, I113V, S119T, T124A, T125TA, F181L, V201I, A205S, T206S, D207E, K211R, K219N, N222K	B
	IN_878	IN_878		RAL		Y143R		S17N, V31I, I113V, T124N, T125A, V126M, T206S, D256E, A265V	B
	IN_1656	IN_1656		RAL		Y143R	T97A, G163R	E11D, S24N, D25E, V31I, L101I, K111R, T112A, S119P, T122I, T125A, R187K, I220L, K240KR	B
	IN_929	IN_929		RAL		Y143R	T97A	E11D, D25E, V31I, L101I, K111T, S119P, T122I	B
	IN_2012	IN_2012		RAL		Y143R	T97A, G163EK	K7Q, E10A, E11D, K14R, V31I, L45V, L101I, T125A, E170EQ, G193R, V201I, I208M, E212A, Q216H, K219Q, S230N, D256E	B
	IN_1235	IN_1235		RAL		Y143R	L74M, Q95QK, T97TA	E11D, S24N, V31I, L101I, T112A, I113LV, T124A, T206S, I208M, D278DN	B
	IN_758	IN_758		RAL		Y143R	T97A	V31I, L74I, T112I, T124A, T125A, V126M, E157Q, K160Q, F181L, T206S, N254Q, S255SG, V259VI, S283SG	B
	IN_1409	IN_1409		RAL		Y143R, N155NH	Q95K	D6E, E11D, V31I, V32I, V37I, S39N, L101I, S119ST, T124A, T125V, V201I, T206S, D207E, N222K, Q252QR, C280S	B
	IN_2205	IN_2205		RAL		Y143R	T97A	K7R, S39C, I72V, L101I, T124A, V201I, Q216H, Q221N	B
	IN_1608	IN_1608		RAL		E138EK, Y143R	L74M, T97A	K14R, S17N, A23V, L28I, P30A, S39C, Q95QR, L101I, T112V, S119G, T122I, T125Q, V201I, T206S, K240R, V259VI	B
	IN_1804	IN_1804		RAL		Y143R	T97A, A128T	E11D, S24N, D25E, V31I, L45V, T112TA, S119P, G163T, K211R	B
	IN_1514	IN_1514		RAL		Y143R	L74LM, T97A, G163K	V31I, L45I, A49P, L101I, S119SG, T122TI, V201I, K215N	B
	IN_487	IN_487		RAL		Y143R	L74M, Q95QK, T97A	E10D, V31I, L63LI, L101I, T112A, S119T, T124A, T125A, I135V	B
	IN_2290	IN_2290		RAL		Y143R		K14R, L28I, P30A, S39SC, L101I, T112AV, V201I, T206S, K211R, T218I, N222NH, L234V, K240R	B
	IN_1513	IN_1513		RAL		Y143R	L74LM, T97A, E138ED, G163K	V31I, L45I, A49P, L101I, S119SG, T122TI, V201I, K215N	B
	IN_92	IN_92		RAL		Y143R		E11D, R20K, T112TA, S195T, V201I, P233PQ	B
	IN_1251	IN_1251		RAL		Y143R	T97A	E11D, V31I, L101I, K111N, S119P, G163T, L234I, D253DH, S283SDGN	B
	IN_2186	IN_2186		RAL		Y143R	T97A	K7R, M50V, I72V, L74I, L101I, S119P, I135V, G163GE, H171Q	B
	IN_332	IN_332		RAL		Y143R	T97A, E138D	E11D, S17C, L101I, K111KR, T112K, S119G, T122I, T124TN, T125A, T218S	B

Integrase Inhibitors

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