<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation Y143R
Rx >=1 INI
IncludeMixtures No
References 11
Patients 20
Isolates 28
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Canducci (2009)pt2pt2w24EU908741RAL26Y143R S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256EB
 pt1pt1w24EU908745RAL26Y143R S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216HB
  pt1w48EU908746RAL39Y143R S17SN, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216HB
Delelis (2009)Pt1Pt1 RAL48Y143R V32I, S39C, K111R, T124N, T125A, G193E, N254KB
 Pt2Pt2 RAL42Y143R A205S, I208L, K211Q, E212AB
 Pt3Pt3 RAL16Y143R I113V, T124NS, T125A, T206S, I220L, Y227FB
Garrido (2009)Pt03Pt03 RAL Y143RT97AH12HN, V31I, K111T, S119T, T125A, V126L, I135V, P142A, I203M, I208L, D256EB
Sichtig (2009)Pt014786FJ183692RAL47Y143RL74M, T97AE11D, R20K, V31I, H51HR, S119G, T122I, T125A, V201I, K215NB
 Pt105150FJ183702RAL106Y143RL74M, T97A, E138DS17N, M22I, A23V, L28I, L45V, L101I, S119T, T218TS, L234LV, D256E, I268MB
Hatano (2010)4Virus15GU121691RAL Y143RT97AK7R, S17N, V31I, L101I, T112A, T125A, M154I, V201IB
  Virus16GU121692RAL Y143RT97A, G163GRK7R, S17N, V31I, L101I, T112A, S119T, T125A, M154I, V201VIB
 9Virus49GU121725RAL E92EQ, Y143RT97TAS17N, V31I, L101I, T124A, A169AG, L234IB
Blanco (2011)JGG_03BLJGG_03BL RAL Y143RL74M, E138DV31I, T125V, D232EB
Canducci (2011)Pt2Pt2W56JN163884RAL55Y143RT97AL101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G277RB
 Pt3Pt3W24JN163887RAL26Y143R S17N, S24N, I113V, S119T, T124A, T125A, V165I, V201I, T206S, E212K, Q216HB
 Pt6Pt6W24JN163894RAL19Y143R S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E, G277CB
  Pt6W32JN163895RAL28Y143RT97AS17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256EB
 Pt8Pt8w12JN163901RAL13Y143R, N155H S17N, A49S, I72V, T124A, M154I, E170A, V201I, G277RB
Armenia (2012)PT_12PT_12_MO_1JN544085RAL Y143RT97AL101I, S283G, D286DNB
  PT_12_MO_3JN544086RAL Y143RT97AL101I, S283G, D286DNB
  PT_12_MO_7JN544087RAL Y143RT97AL101I, T112TA, S119ST, S283GB
  PT_12_MO_9JN544088RAL Y143RT97AD3DN, D25DE, L101I, T112TA, S119ST, S283GB
Garrido (2012)BAA295956BAA295956JQ716865RAL52Y143RL74MK7R, V31I, L101I, T112I, T125V, K219N, N222KB
 BAA295870BAA295870JQ716888RAL52Y143RT97TA, V151VIS17N, V31I, M50T, I72V, V75VI, T124A, K156N, T206S, I220IV, D232DN, D256EB
Souza Cavalcanti (2012)BRSPBR11SP363BJQ797725RAL135Y143RT97AE11D, E13X, K14R, S24D, L28I, S39C, K42KR, L74I, S119P, Q164K, R187K, V201I, D232E, L234IB
de Souza Cavalcanti (2014)BRSP222BRSP222 RAL Y143RL74M, T97A, E138DE10D, V31I, M50I, L101I, T112V, S119P, T122I, T124N, T125A, I135V, E157Q, I203M, I208L, T218S, I220L, D253VB
 BRSP358BRSP358 RAL Y143R S17N, L28I, P30A, I72IV, T112A, K211RB
 BRSP75BRSP75 RAL Y143R E11D, S24N, V31I, T112TA, I113IV, S119T, T124N, T125V, I203IM, K219N, I220L, N222KB