<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation Y143R
Rx >=1 INI
IncludeMixtures No
References 12
Patients 59
Isolates 67
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Canducci (2009)pt2pt2w24EU908741RAL26Y143R S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256EB
 pt1pt1w24EU908745RAL26Y143R S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216HB
  pt1w48EU908746RAL39Y143R S17SN, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216HB
Delelis (2009)Pt1Pt1 RAL48Y143R V32I, S39C, K111R, T124N, T125A, G193E, N254KB
 Pt2Pt2 RAL42Y143R A205S, I208L, K211Q, E212AB
 Pt3Pt3 RAL16Y143R I113V, T124NS, T125A, T206S, I220L, Y227FB
Garrido (2009)Pt03Pt03 RAL Y143RT97AH12HN, V31I, K111T, S119T, T125A, V126L, I135V, P142A, I203M, I208L, D256EB
Sichtig (2009)Pt014786FJ183692RAL47Y143RL74M, T97AE11D, R20K, V31I, H51HR, S119G, T122I, T125A, V201I, K215NB
 Pt105150FJ183702RAL106Y143RL74M, T97A, E138DS17N, M22I, A23V, L28I, L45V, L101I, S119T, T218TS, L234LV, D256E, I268MB
Hatano (2010)4Virus15GU121691RAL Y143RT97AK7R, S17N, V31I, L101I, T112A, T125A, M154I, V201IB
  Virus16GU121692RAL Y143RT97A, G163GRK7R, S17N, V31I, L101I, T112A, S119T, T125A, M154I, V201VIB
 9Virus49GU121725RAL E92EQ, Y143RT97TAS17N, V31I, L101I, T124A, A169AG, L234IB
Blanco (2011)JGG_03BLJGG_03BL RAL Y143RL74M, E138DV31I, T125V, D232EB
Canducci (2011)Pt2Pt2W56JN163884RAL55Y143RT97AL101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G277RB
 Pt3Pt3W24JN163887RAL26Y143R S17N, S24N, I113V, S119T, T124A, T125A, V165I, V201I, T206S, E212K, Q216HB
 Pt6Pt6W24JN163894RAL19Y143R S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E, G277CB
  Pt6W32JN163895RAL28Y143RT97AS17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256EB
 Pt8Pt8w12JN163901RAL13Y143R, N155H S17N, A49S, I72V, T124A, M154I, E170A, V201I, G277RB
Armenia (2012)PT_12PT_12_MO_1JN544085RAL Y143RT97AL101I, S283G, D286DNB
  PT_12_MO_3JN544086RAL Y143RT97AL101I, S283G, D286DNB
  PT_12_MO_7JN544087RAL Y143RT97AL101I, T112TA, S119ST, S283GB
  PT_12_MO_9JN544088RAL Y143RT97AD3DN, D25DE, L101I, T112TA, S119ST, S283GB
Garrido (2012)BAA295956BAA295956JQ716865RAL52Y143RL74MK7R, V31I, L101I, T112I, T125V, K219N, N222KB
 BAA295870BAA295870JQ716888RAL52Y143RT97TA, V151VIS17N, V31I, M50T, I72V, V75VI, T124A, K156N, T206S, I220IV, D232DN, D256EB
Souza Cavalcanti (2012)BRSPBR11SP363BJQ797725RAL135Y143RT97AE11D, E13ED, K14R, S24D, L28I, S39C, K42KR, L74I, S119P, Q164K, R187K, V201I, D232E, L234IB
de Souza Cavalcanti (2014)BRSP222BRSP222 RAL Y143RL74M, T97A, E138DE10D, V31I, M50I, L101I, T112V, S119P, T122I, T124N, T125A, I135V, E157Q, I203M, I208L, T218S, I220L, D253VB
 BRSP358BRSP358 RAL Y143R S17N, L28I, P30A, I72IV, T112A, K211RB
 BRSP75BRSP75 RAL Y143R E11D, S24N, V31I, T112TA, I113IV, S119T, T124N, T125V, I203IM, K219N, I220L, N222KB
Hurt (2014)IN_954IN_954 RAL Y143RL74M, Q95K, T97AD6E, E10D, S17T, A23V, A91T, L101I, S119P, T122I, T124A, T125AB
 IN_819IN_819 RAL Y143RG163RV31I, I72V, V75M, T206S, S230NB
 IN_1881IN_1881 RAL Y143RT97AV32I, D41N, I72V, V126M, T206SB
 IN_1169IN_1169 RAL Y143RL74ME11D, S24N, V31I, L101I, T112A, S119ST, E157EQ, K160KI, V201I, T218L, K219Q, L234IB
 IN_1256IN_1256 RAL Y143RT97TAE11D, V31I, M50I, K111T, S119SG, T122I, T124S, V201IB
 IN_800IN_800 RAL Y143RL74M, T97AS17N, S119T, E157Q, K160Q, V201I, D256E, R284GB
 IN_212IN_212 RAL Y143RL74M, T97AS17N, R20K, V31I, T112S, I113V, S119ST, T124S, T125A, E157Q, K160Q, V201I, K211R, R284GB
 IN_1642IN_1642 RAL Y143RL74M, T97AS17N, L101I, S119G, T122I, T124A, T125A, L234V, V259IB
 IN_2840IN_2840 RAL Y143R Y15YF, S17N, N18NH, L45I, M50I, L101I, K111KR, T112R, T124A, T125A, K156N, V201I, D256EB
 IN_1518IN_1518 RAL Y143RT97AD6E, S17N, V31I, L101I, S119T, T124TN, T206S, D232EB
 IN_848IN_848 RAL Y143RL74MS17N, V31VI, L63LI, I72N, L101I, T112I, S119P, V201I, D256E, V259VI, R284RGB
 IN_3286IN_3286 RAL Y143R S17N, L45V, I72V, I113V, S119P, T124A, V150VA, V201I, K211Q, T218S, D256E, D270NB
 IN_3316IN_3316 RAL Y143RL74LM, T97AM22I, L28M, V31VI, V32I, I60IM, L101I, S119P, T122TI, T124N, G163V, Q216N, Q221RB
 IN_1770IN_1770 RAL Y143R D25E, V31I, M50MI, L74I, K111KR, S119T, T125A, G163Q, V201VI, T218SB
 IN_984IN_984 RAL Y143R S17N, P30S, M50I, I72V, T124A, T125A, T206S, D253E, S255K, S283GB
 IN_1789IN_1789 RAL Y143RT97A, G163RS24N, S119P, T125A, I135V, T206S, T210I, S283GB
 IN_2021IN_2021 RAL Y143RT97AV31I, I60M, L74I, T112I, T124A, T125A, V126M, E157Q, K160Q, F181L, T206S, N254QB
 IN_214IN_214 RAL Y143RL74M, Q95QK, T97AE10D, V31I, L101I, T112A, S119T, T124A, T125A, I135VB
 IN_1321IN_1321 RAL Y143RL74IM, T97AK14KR, S17N, T112A, S119T, T124A, T125A, A128PS, V201IB
 IN_266IN_266 RAL Y143RL68V, L74M, T97AV31I, L101I, S119T, G163Q, F181L, T206SB
 IN_1599IN_1599 RAL Y143RL74M, Q95QK, T97AE11D, V31I, I72V, I113V, S119T, T124A, T125TA, F181L, V201I, A205S, T206S, D207E, K211R, K219N, N222KB
 IN_878IN_878 RAL Y143R S17N, V31I, I113V, T124N, T125A, V126M, T206S, D256E, A265VB
 IN_1656IN_1656 RAL Y143RT97A, G163RE11D, S24N, D25E, V31I, L101I, K111R, T112A, S119P, T122I, T125A, R187K, I220L, K240KRB
 IN_929IN_929 RAL Y143RT97AE11D, D25E, V31I, L101I, K111T, S119P, T122IB
 IN_2012IN_2012 RAL Y143RT97A, G163EKK7Q, E10A, E11D, K14R, V31I, L45V, L101I, T125A, E170EQ, G193R, V201I, I208M, E212A, Q216H, K219Q, S230N, D256EB
 IN_1235IN_1235 RAL Y143RL74M, Q95QK, T97TAE11D, S24N, V31I, L101I, T112A, I113LV, T124A, T206S, I208M, D278DNB
 IN_758IN_758 RAL Y143RT97AV31I, L74I, T112I, T124A, T125A, V126M, E157Q, K160Q, F181L, T206S, N254Q, S255SG, V259VI, S283SGB
 IN_1409IN_1409 RAL Y143R, N155NHQ95KD6E, E11D, V31I, V32I, V37I, S39N, L101I, S119ST, T124A, T125V, V201I, T206S, D207E, N222K, Q252QR, C280SB
 IN_2205IN_2205 RAL Y143RT97AK7R, S39C, I72V, L101I, T124A, V201I, Q216H, Q221NB
 IN_1608IN_1608 RAL E138EK, Y143RL74M, T97AK14R, S17N, A23V, L28I, P30A, S39C, Q95QR, L101I, T112V, S119G, T122I, T125Q, V201I, T206S, K240R, V259VIB
 IN_1804IN_1804 RAL Y143RT97A, A128TE11D, S24N, D25E, V31I, L45V, T112TA, S119P, G163T, K211RB
 IN_1514IN_1514 RAL Y143RL74LM, T97A, G163KV31I, L45I, A49P, L101I, S119SG, T122TI, V201I, K215NB
 IN_487IN_487 RAL Y143RL74M, Q95QK, T97AE10D, V31I, L63LI, L101I, T112A, S119T, T124A, T125A, I135VB
 IN_2290IN_2290 RAL Y143R K14R, L28I, P30A, S39SC, L101I, T112AV, V201I, T206S, K211R, T218I, N222NH, L234V, K240RB
 IN_1513IN_1513 RAL Y143RL74LM, T97A, E138ED, G163KV31I, L45I, A49P, L101I, S119SG, T122TI, V201I, K215NB
 IN_92IN_92 RAL Y143R E11D, R20K, T112TA, S195T, V201I, P233PQB
 IN_1251IN_1251 RAL Y143RT97AE11D, V31I, L101I, K111N, S119P, G163T, L234I, D253DH, S283SDGNB
 IN_2186IN_2186 RAL Y143RT97AK7R, M50V, I72V, L74I, L101I, S119P, I135V, G163GE, H171QB
 IN_332IN_332 RAL Y143RT97A, E138DE11D, S17C, L101I, K111KR, T112K, S119G, T122I, T124TN, T125A, T218SB