Integrase Inhibitors

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Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	G140S
Rx	>=1 INI
IncludeMixtures	No

References	13
Patients	27
Isolates	48

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	Wks	INIMajorDRMs	INIMinorDRMs	OtherMut	Subtype
Charpentier (2008)	Pt3	Pt3-W15		RAL	15	G140S, Q148R		I72V, T124TA, K156N, D167E, S283G, D288N	B
Malet (2008)	1a	SH1-W12	FJ538986	RAL	13	G140S, Q148H		K7Q, E11D, V31I, M50L, I72V, L101I, T124A, I135V, I200L, V201I, I220L	B
	1b	H-SH1-W16	FJ538991	RAL	15	G140S, Q148H		E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
	1c	SH2-W10	FJ538988	RAL	11	G140S, Q148H		S17N, L28I, S39C, S119P, T122I, T124A, T125A	B
	HSH2	H-SH2-W22	FJ538994	RAL	22	G140S, Q148H	G163R	S17N, R20K, L28I, S39C, G70R, T124A, T125A, V201I, I208L	B
Baldanti (2009)	PV5	PV5	GU350729	RAL	26	G140S, Q148H		E13D, L101I, M154L, V165I, A196P, V201I, I208L, L234V, D256E	B
	PV3	PV3	GU350736	RAL	13	G140S, Q148H, N155H		S17N, I72V, T124A, M154I, E170A, V201I	B
Canducci (2009)	pt6	pt6W12	EU908750	RAL	13	G140S, Q148R		D3N, L101I, K156N, I208L	B
		pt6W36	EU908753	RAL	39	G140S, Q148H	T97A	L101I, S119R, K156N, I208L	B
		pt6w48	EU908754	RAL	52	E138A, G140S, Y143H, Q148H		L101I, S119R, K156N, I208L, R224RG	B
	pt3	pt3w24	EU908758	RAL	26	G140S, Q148H	V54I	V31I, I113V, T124A, T125A, V201I, K215N	B
Garrido (2009)	Pt02	Pt02		RAL		G140S, Q148R		E11D, V31VI, V32I, V37I, L101I, V201I, D232E, D256E	B
Sichtig (2009)		5068	FJ183700	RAL	35	G140S, Q148H	G163K	S17N, R20K, L28I, S39C, L45V, I113V, T124N, T125A, V201I, V259I	B
		5864	FJ183701	RAL	79	G140S, Q148H	G163EKQ	S17N, R20K, L28I, S39C, L45V, I113L, T124N, T125A, V201I	B
Wittkop (2009)	1	1_M6	GU358379	RAL	25	G140S, Q148H		E10D, R20K, V32I, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K	B
		1_M9	GU358380	RAL	39	E138EA, G140S, Q148H		E10D, R20K, V32I, L45LI, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K, V259VI	B
		1_M12	GU358381	RAL	52	E138EA, G140S, Q148H		E10D, R20K, V32VI, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K, V259VI	B
	5	5_M1	GU358392	RAL	4	G140S, Q148H		E11D, E13D, V31I, M50I, S57G, I89V, S119P, T122I, T124A, T206S, S255N, D256E, S283G	B
		5_M3	GU358393	RAL	12	G140S, Q148H		E11D, E13D, V31I, M50I, S57G, S119P, T122I, T124A, T206S, S255N, D256E, S283G	B
		5_M6	GU358394	RAL	25	G140S, Q148H		E11D, E13D, V31I, M50I, S57G, L63LI, S119P, T122I, T124A, T206S, T210TS, S255N, D256E, S283G	B
		5_M9	GU358395	RAL	39	G140S, Q148H	L74LM	E11D, E13D, V31I, K34KR, M50I, S57G, L63I, S119P, T122I, T124A, T206S, I208IL, S255N, D256E, S283G	B
	2	2_M6	GU358401	RAL	25	G140S, Q148H		D3DN, E10ED, R20K, K160R, V201I	B
		2_M9	GU358402	RAL	39	G140S, Q148H		D3DN, R20K, K160R, V201I	B
Hatano (2010)	1	Virus4	GU121680	RAL		G140S, Q148H		S17N, S24D, S39C, L45LQ, L101I, T124N, D167E, V201I, E212A, R284G, D286N	B
		Virus5	GU121681	RAL		G140S, Q148H		S17N, S24D, S39C, L45LQ, L101I, T124N, D167E, V201I, E212A, R284G, D286N	B
	2	Virus114	GU121790	RAL		G140S, Q148H		L63I, I73V, L74I, E96D, L101I, T112I, I208L, D232E, L234LF	B
		Virus8	GU121684	RAL		G140S, Q148H		L63I, I73V, L74I, E96D, L101I, T112I, I208L, D232E	B
	5	Virus27	GU121703	RAL		G140S, Q148H		S17N, I72V, L101I, K156N, V201I, D207DG, I208L	B
	7	Virus129	GU121805	RAL		G140S, Q148H	V151I	D25E, I72V, K211R, K215N	B
Blanco (2011)	CA8070	CA124205		RAL	29	G140S, Q148H		K14R, L101I, T112A, G193E, D279G	B
		CA124204		RAL	85	G140S, Y143YH, Q148H		K14R, L63I, L101I, T112A, G193E, D279G	B
		CA128615		RAL	113	G140S, Q148H		K14R, Q44QH, L63I, L101I, T112A, G193E, D229E, D279G	B
		CA153556		RAL	161	G140S, Q148H		K14R, L63I, L101I, T112AS, G193E, V201VI, D229E, D279G	B
	CLD_01_B	CLD_01_B		RAL		G140S, Q148H		E11D, S24G, L28I, L101I, I113L, T122I, T124A, V201VI	B
	DCR_02BL	DCR_02BL		RAL		G140S, Q148H		A23V, V31I, T125V, D232E, A265V	B
	JRM_04BL	JRM_04BL		RAL		G140S, Q148H		K14R, V32I, S39C, L101I, T112I, I135V, V201I, T206S, T218S, I220V, K240R, C280S, D286N	B
Brenner (2011)	INT21	INT21	HQ207822	RAL		G140S, Q148H		L45V, L101I, E157Q, K160Q, K215N, D232N, D256E	B
	092807.021	092807.021	HQ423434	RAL		G140S, Q148H		E11D, M50I, G193E, V201I, D232DN, D256E, D286DN	B
	093107.007	093107.007	HQ423436	RAL		G140S, Q148H	G163EK	V31I, L45I, L101I, S119G, T122I, E157Q, K160Q, V176L, V201I, I208M, K215N, L234I, D253H, D256E	B
	090808.001	090808.001	HQ423438	RAL		G140S, Q148H		E11D, V31VIM, L101I, K111AS, T125TA, I135V, K156N, R187K, V201I, I220IV, S283SG	B
	10806	10806	HQ423445	RAL		G140S, Q148H		E11D, S24N, D25E, M50I, K111T, T112TK, I203M	B
Garrido (2012)	BAA295893	BAA295893	JQ716870	RAL	52	G140S, Q148H		E11D, S24N, V31I, T112IM, T206S, I208L, D253DE	B
	BAA295889	BAA295889	JQ716890	RAL	52	G140S, Q148H		D6E, K14R, S17SN, V31I, L101I, K111KE, A128AV, I135V, G163Q, G193E, V201I, D256E	B
Lee (2012)	3180	41193A.8	JQ666905	RAL	28	G140S, Q148H		S17N, S24D, S39C, L45LQ, L101I, T124N, D167E, V201I, E212A, R284G, D286N	B
Parczewski (2012)	103	103_42	KC409138	RAL	84	G140S, Q148H		E11D, R20K, G70D, I73IV, L101I, S119R, T124N, G193E, S195T, T206S, T218TS, D270N	B
		103_43	KC409139	RAL	96	G140S, Q148H		E11D, R20K, G70D, L101I, S119R, T124N, G193E, S195T, T206S, T218TS, D270N	B
		103_46	KC409140	RAL	145	G140S, Q148H		E11D, R20K, G70D, L101I, S119R, T124N, T125TS, G193E, S195T, T206S, T218TS, D270N	B
		103_49	KC409141	RAL	180	G140S, Q148H		E11D, R20K, G70D, K71KR, L101I, S119R, T124N, T125TS, G193E, S195T, T206S, T218S, D270N	B

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