<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation E138K
Rx >=1 INI
IncludeMixtures No
References 7
Patients 32
Isolates 37
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Hatano (2010)17Virus99GU121775EVG E138K, S147G, Q148R K7KR, I72V, V79VI, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus100GU121776EVG E138K, S147G, Q148RV54VIK7KR, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus103GU121779EVG E138K, S147G, Q148RV54VIK7KR, E35EQ, I72IV, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus20GU121696EVG E138K, S147G, Q148RV54IK7KR, E35EK, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
Brenner (2011)092810.002092810.002HQ423435RAL E138K, G140A, Q148K S17N, L28I, P30A, I60V, G106A, T115M, T124TN, I208M, D232N, D256EB
Canducci (2011)Pt1Pt1W8BJN163875RAL8E138K, Q148R L101I, K156N, I208LB
Souza Cavalcanti (2012)BRSPBR10SP296JQ797733RAL130E138K, G140C, Q148RV54IE11D, V31I, V32I, V37I, D41N, V79I, L101I, T125A, K136Q, V201I, T206S, L234V, D270EB
de Souza Cavalcanti (2014)BRSP318BRSP318 RAL E138K, G140C, Q148RV54I, L74MD6T, K7E, K14R, V31I, I72V, V79I, S119P, K156KN, E157Q, K160KT, V201I, T218S, R284GB
 BRSP296BRSP296 RAL E138K, G140C, Q148RV54IE11D, V31I, V32I, V37I, D41N, V79I, L101I, T125A, K136Q, V201I, T206S, L234V, D270EB
 BRSP239BRSP239 RAL E138K, S147G, Q148RV151I, G163RK14R, L74I, V75M, V79I, S119P, T122I, T124A, T125A, K156N, V201I, T218I, L234V, D256E, S283G, R284GB
Hardy (2014)Pt1INTPt1INT RAL, DTG110E138K, S147G, N155HT97A, V151ID6DN, R20RK, V31I, L45I, L101I, S119R, I135V, E157Q, K160Q, V201I, K215NB
  Pt1INT RAL, DTG157E138K, S147G, N155HT97A, V151IR20K, V31I, L45I, A49P, L101I, S119R, T122TAIV, I135V, E157Q, K160Q, V201I, K215N, L234VB
  Pt1INT RAL, DTG168E138K, S147G, N155HT97A, V151IR20RK, V31I, L45I, A49P, L68LF, L101I, S119R, T122TAIV, I135V, E157Q, K160Q, V201I, K215N, L234VB
Hurt (2014)IN_1739IN_1739 RAL E138K, G140S, Q148H I72V, L101I, Y194C, I220M, N222K, Y227F, A265V, R284GB
 IN_1622IN_1622 RAL E138K, S147G, Q148RQ95KK14R, R20K, V32I, L45V, L101I, K103R, T124A, G163E, V201I, K215N, N222K, D270HB
 IN_399IN_399 RAL E138K, G140S, Q148H E10D, V31I, A49P, I72V, T112A, T124A, K156N, V165IB
 IN_79IN_79 RAL E138K, G140GS, S147SG, Q148KR E11D, V79VI, T93S, L101I, G189R, V201I, K211Q, Q216H, T218S, N222K, S230N, L234I, A265V, K273QB
 IN_65IN_65 RAL E138K, S147G, Q148R K7R, K14R, K71N, V79VI, A91AT, S119R, T124N, T125A, K156N, G193E, V201I, N222K, S230N, L234VB
 IN_543IN_543 RAL E138K, Q148RA128TS17N, I72V, P90S, L101I, K156N, V201I, I220VB
 IN_663IN_663 RAL E138K, G140S, Q148H I72V, L101I, Y194C, I220M, N222K, Y227F, A265V, R284GB
 IN_265IN_265 RAL E138K, G140S, Q148H K14R, V31I, S39C, M50I, L101I, T124A, M154I, V201I, K211Q, S230N, L234I, D253EB
 IN_1752IN_1752 RAL E138K, Y143CL74M, T97A, A128T, S230RE13D, K14KR, S17N, V31I, L63LI, L101I, T112A, S119R, K156N, I208L, Q252K, D288NB
 IN_2222IN_2222 RAL E138K, S147G, Q148RG163RM50I, V79I, Y99F, L101I, M154MI, K156N, K211KRB
 IN_2513IN_2513 RAL E138K, G140S, Q148H S17N, T124N, T125A, K127KR, M154I, V165IB
 IN_946IN_946 RAL E138K, G140A, Q148K T112I, T122I, T124N, D256E, D278DG, R284G, D288NB
 IN_2095IN_2095 RAL E138K, S147G, Q148RV54VI, V151VIV31I, A49P, L74I, V79I, L101I, T124TA, I141V, I203IM, I204IVB
 IN_167IN_167 RAL E138K, Y143YCHR, Q148QR V31I, L45V, C56Y, I72V, T125V, D167E, K188R, C280CGB
 IN_3116IN_3116 RAL E138K, G140S, Q148H S24SN, V31I, M50I, T112TI, K188R, V201I, T206S, I208IL, K215S, S230G, K264RB
 IN_3256IN_3256 RAL E138K, G140S, Q148H R20RK, S39C, M50MT, I84IL, L101I, K136N, M154I, D167E, V201I, K215KN, K244KRB
 IN_1723IN_1723 RAL E138K, G140C, Q148RV54IV79I, T124A, K136N, V201VI, I208M, L234H, V259I, R284GB
 IN_1638IN_1638 RAL E138K, S147G, Q148RQ95KK14R, R20K, V32I, L45V, L101I, K103R, T124A, G163E, V201I, K215N, N222K, D270HB
 IN_1439IN_1439 RAL E138K, Q148R S17N, L28I, M50I, I72V, T124A, K156N, I162V, I208L, D256EB
 IN_1121IN_1121 RAL E138K, G140S, Q148RG163GRE11ED, K14KR, S39SN, L45LI, T112A, T124A, T125A, K136E, K156N, G193R, T206S, I208L, K211KQ, E212A, T218S, D232DN, L234I, A265AVB
 IN_746IN_746 RAL E138K, Q148R E13ED, L45AV, K111R, T112TI, T124A, T125A, V126L, K211R, S230N, R284RGB
 IN_2253IN_2253 RAL E138K, G140A, Q148K E11D, A21T, V31I, L45V, L101I, K111T, I113V, T125A, G163T, I203M, T218S, K219KT, D253E, D256E, D279GB
 IN_2925IN_2925 RAL E138K, Q148RV151VIM50I, I72V, L101I, T112V, T124A, I135V, K160KN, D167E, V201I, R284GB
 IN_352IN_352 RAL E138K, G140S, Q148H E11D, K14R, V32I, S39C, V88I, L101I, K103R, S119G, T122I, T125A, I200M, V201I, T206SB