<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation E138D
Rx II-naive
IncludeMixtures No
References 24
Patients 46
Isolates 46
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Hierholzer (2002)EC003EC003AY173959None  E138DS17N, M50I, V77A, L101I, T124A, T125A, V201I, K215N, I220L, V259IB
de Sa Filho (2006)BREPM11931BREPM11931DQ085869None  E138DE10D, A21S, V31I, M50I, K71N, I72V, G106R, N117H, T125A, K156NB
 BREPM11932BREPM11932DQ085870None  E138D, V151IE10D, A21S, M50I, I72V, I113V, T125AB
Brennan (2008)851-30851-30EU618313None  E138DV31I, I72V, L101I, T124N, T206TS, Y227F, D256E, A265V, S283GB
Miura (2008)BEC5BEC5EU517861None  E138DS17N, M50T, T125A, V201I, K219T, I220LB
 BEC86BEC86EU517889None  E138DE11D, V31I, I60M, I72V, K173Q, S230N, D232E, A265V, D286NB
Brumme (2009)A2572A2572GQ371770None  E138DS17N, I72V, P90S, L101I, T124A, T125A, V201IB
 D4506D4506GQ371821None  E138D, P145PL, V151VLS17N, L28I, S39C, L101I, T124A, T125A, I135V, P142PS, V150A, K173KR, I220L, Y227FB
 M2511M2511GQ372005None  E138DS17C, L101I, T125A, Q216H, A265V, D286DNB
Garrido (2009)399INT-399GU217246None  E138DK14R, S17SC, L28I, P30PA, S39C, I60V, L101I, T124TA, T125AS, I135IV, K211R, I220IV, A265AVB
Low (2009)mdr13mdr13FJ786398None  E138DS17N, V32I, L101I, T112A, T124N, T125A, V165I, K211Q, E212AB
Passaes (2009)BR.RJ.FT14BR.RJ.FT14HM026775None  E138DD6N, E13D, V32I, K42R, L101I, T124N, T206S, D229E, R284GB
Rangel (2010)HIV264bHIV264bGU797536None  E138DL28I, V31I, S39C, L101I, V201I, T206S, K215N, D229EB
 HIV264pHIV264pGU797537None  E138DL28I, V31I, S39C, L101I, V201I, T206S, K215N, D229EB
Kousiappa (2011)CY258CY258JF683801None  E138DS17N, A23V, L28I, P30A, A38S, I72V, L74I, I89L, T124A, V201I, T218S, D253E, D256E, S283GB
Sanabani (2011)BR1055BR1055JN692454None  E138DE11D, K14R, A21T, I113V, T124S, T125A, S230N, L234V, S255N, V281MB
Garrido (2012)BAA295935BAA295935JQ716911None  E138DV32I, D41N, I72V, L101I, T122I, T124A, V201IB
Iamarino (2012)BF.BR.0709BF.BR.0709JN234050None  E138DS17N, K34R, M50L, I72V, L101I, K111Q, S119G, T124N, T206S, D207E, Y227F, D232E, D253Y, D256E, A265V, V281A, R284T, Q285PB
Molina (2012)32633263_1 None  E138DK14R, S17N, V31VI, I60M, L101I, T112V, T124A, I135IV, K188KR, V201I, A265V, S283G, R284RG, D286NB
 30773077_1 None  E138DV31I, M50I, C65CG, I72IV, N117NK, T124N, T125A, D167E, V201I, A265V, D286NB
Reigadas (2013)55JX425473None  E138DE11D, M50I, I60V, I72V, K111T, S119G, T122I, V126M, T206S, I208MB
 212212JX425679None  E138DD3E, S17N, L101I, I113V, T124A, V201I, T218S, I220L, C280SB
Chikata (2014)KI-474KI-474AB874078None  E138DS17N, L28I, P30A, S39C, A76AG, I84M, L101I, T112A, T125A, V201I, I203MB
 KI-904KI-904AB874201None  E138DK14R, V31I, I36L, S39R, L101I, T125A, G163E, V201I, I220LB
 KI-863KI-863AB874171None  E138DE10D, L28I, S39C, L101I, T112A, T125A, D167E, L234I, R269RK, Q285QPB
Stekler (2014)PIC1890PFW54PIC1890PFW54KJ152021None  E138DK71Q, L101I, S119P, T122I, T124N, I208L, K211T, E212A, S230N, A265V, S283GB
Hachiya (2015)N0731N0731LC022483None  E138DK14R, G106A, T124A, T125A, I135V, I200M, V201I, S255GB
 N0884N0884LC022561None  E138DG106A, T124A, T125A, I135V, I200M, V201I, S255GB
Hora (2015)DEMB11FR001DEMB11FR001KF716496None  E138DK188R, V201I, A265VB
Kinloch (2015)INT_131INT_131KT167690None  E138DL45V, T124S, T125M, G163GEB
 INT_56INT_56KT167615None  E138DS17SN, I72V, T124A, S230N, A265VB
Pessoa (2016)10BR_RJ03010BR_RJ030KT427781None  E138DE11D, S24N, D25E, L28I, I72V, A91S, L101I, T122I, T124N, V176L, K188R, A265VB
 10BR_RJ08310BR_RJ083KT427766None  E138DS17N, V31I, M50I, L74I, S119P, T122I, T124A, T125A, K160R, T218S, I220M, Y227F, D256E, S283GB
 10BR_RJ11110BR_RJ111KT427748None  E138DE11D, L28I, V37I, S39C, I60M, A91T, L101I, K111T, S230N, D253E, S283GB
 10BR_MG01110BR_MG011KT427688None  E138DK7R, E10A, S17N, T124A, T125A, K156QB
Chen (2017)220512123220512123KY574986None  E138DK14R, L45V, I72V, I84M, T124A, T125A, V126L, I161L, V201IB
 220512755220512755KY434654None  E138DK7R, A23V, I72V, I84L, L101I, T124A, V201I, S283GB
Hachiya (2017)C14-51111660LC160917LC160917None  E138DE11D, V31I, T124N, R187K, V201I, S230N, A265V, S283GB
 C14-55554436458LC161065LC161065None  E138DW19WG, M22MT, G106A, T124A, T125A, I135V, I200M, V201I, S255GB
 C14-55553025LC161071LC161071None  E138DS17N, L28I, S39C, L101I, T124N, T125AB
 C14-2069107LC171119LC171119None  E138DS17N, L28I, S39C, L101I, T124N, T125AB
 C14-2069128LC171134LC171134None  E138DV31I, T124N, T125X, V126X, V201I, K211Q, S230N, S283GB
Meixenberger (2017)95-0441395-04413KM677487None  E138DS17C, M50I, I72V, T122I, T125A, K160QB
 99-0273899-02738KM677526None  E138DS17C, L45I, I72V, L101LF, T125A, K160QB
 05-0032305-00323KM677610None  E138DE11D, S24N, L45I, L101I, K111KT, T112V, S119SG, I135V, D232E, L234I, D253EB
 05-0090405-00904KM677622None  E138DE11D, S24N, L101I, T112X, S119SG, T125X, I135V, D232E, L234I, D253EB