<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation T125V
Rx II-naive
IncludeMixtures No
References 41
Patients 175
Isolates 175
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
McLaughlin (2004)98USHVTN8229c698_8229c6AY560109None   L101I, T124N, T125V, I135V, D167E, I208L, K211Q, D232E, D256EB
 98USHVTN941c198_941c1AY560110None   S24A, D25N, S119T, T124N, T125V, E198D, V201I, T206S, D256EB
Saad (2005)SM_02YE51902YE519AY795908None   E11D, A23V, S24N, I72V, L101I, T125V, K156R, E157Q, K160Q, K215N, D253EB
Zarandia (2006)98GEMZ00198GEMZ001DQ207940None   D6E, E13D, I73V, L101I, T112I, T124A, T125V, S153T, Q216HB
Andresen (2007)PMVL 013PMVL013EF514700None   E11D, A23V, I73V, L101I, K111R, T112I, S119G, T124Q, T125V, V201I, S283NB
 CTL 030CTL030EF514708None   D6E, E10D, I72V, G106A, T122TI, T124N, T125VB
Lataillade (2007)482-009ML_482-009EF472722None   S17N, M50IT, I72V, S123SG, T124A, T125V, G163E, Y227F, D253HY, S255N, D256EB
 482-079ML_482-079EF472724None   S17N, T124N, T125V, I135V, G163E, V201I, N254Q, D256EB
 63BML_63BEF472784None   S17N, T124N, T125V, I135V, G163E, V201I, N254Q, D256EB
Sa-Filho (2007)BREPM1032BREPM1032EF637051None  V151IE10D, M50I, I72V, S119T, T125V, K173R, S255NB
Struck (2007)luBF_21.06luBF_21.06EU170137None   E11D, R20K, L28I, V37I, S39C, V77A, I84L, L101I, T124A, T125V, G163GE, V180VI, V201I, Q216QH, N222H, L234VB
 luBF_10.03luBF_10.03EU170149None   E11D, R20K, L28I, V37I, S39C, I72V, I84L, L101I, T125V, G163E, V201I, L234VB
 luBF_03.03luBF_03.03EU170152None   E11D, R20K, L28I, V37I, S39C, I84L, L101I, T124TS, T125V, G163E, V201I, L234VB
Buzon (2008)Pt40Pt40Y1995EU883903None   E11D, M50MI, I72V, K111Q, T112V, S119AG, T124N, T125VB
Miura (2008)BEC110BEC110EU517860None   R20RK, S39C, L45Q, I72V, T125V, I220IV, I268L, S283SGB
 BEC36BEC36EU517868None  V151IL28I, I72V, T125V, I220M, Q221H, A265VB
 BEC78BEC78EU517888None   S17N, V31I, I72V, I84L, T112A, T124N, T125V, D232E, A265VB
 BEC108BEC108EU517891None   E10A, T124N, T125V, G163E, K211R, Q252LB
Brumme (2009)INT_3500INT_3500FJ812951None   E11D, S24N, S39C, I72IV, L101I, T124TA, T125V, E157D, V201VIB
 INT_3512INT_3512FJ812963None   T125V, S230NB
 INT_3584INT_3584FJ813035None   E11D, I72V, S119AGPR, T122TI, T124TN, T125V, M154L, T218TI, I220L, Q221HB
 INT_3622INT_3622FJ813073None   S24SN, D25E, V77I, I84M, L101I, S119T, T124N, T125V, V165I, K173KRB
 INT_3631INT_3631FJ813082None   E11D, S17T, I60M, I72V, T124N, T125V, V150A, D167EB
 INT_3744INT_3744FJ813195None   E10D, S39C, I72V, T112I, T122I, T124N, T125V, K211RB
 INT_3781INT_3781FJ813232None   V31VIM, I72V, S119P, T124TN, T125V, V126L, I135IV, A265V, D279DGB
 INT_3788INT_3788FJ813239None   T124TN, T125V, K156N, I162V, V201VIB
 INT_3840INT_3840FJ813291None   E11D, I72V, S119P, T122I, T125V, V201I, K211QB
 INT_3896INT_3896FJ813347None   S17N, I72IV, T125V, G163EB
 INT_4027INT_4027FJ813478None   K7R, E11D, D25E, L28I, S39C, I72V, I113V, T124Q, T125V, I182V, Q216H, L234FB
 B1542B1542GQ371793None   E10D, M50T, I72V, T112I, I113V, T124S, T125V, R187RK, D256EB
 E7538E7538GQ371856None   K7R, S17N, T124N, T125V, I135V, V201I, T206S, I208L, I220M, Q221GB
 F3507F3507GQ371866None   K7R, S17N, M50L, I72V, T112V, I113V, T125VB
 G8521G8521GQ371903None   I72V, K111R, T112I, T125V, I141V, K160R, D167E, V201I, T206S, I220VB
 J4531J4531GQ371941None   S17N, L101I, I113V, T125V, G163E, H171Q, D256EB
 J5505J5505GQ371942None   E11D, V31I, V37I, I72V, L101I, K111RT, S119SAGT, T124N, T125V, I135V, D167E, V201I, Q216N, I220M, V281MB
 K6538K6538GQ371966None   S17N, V31I, I72V, L101I, S119G, T122V, T124A, T125V, K156N, I182V, V201IB
 K9548K9548GQ371974None   S17N, R20K, K34R, M50I, I72V, T112A, T125V, V165I, V201I, K211R, S230N, D256E, K266KRB
 O0539O0539GQ372049None   E10D, E11D, V31I, I113V, T124N, T125V, Q216N, I220MB
 P6501P6501GQ372089None   D6E, E10D, V31I, T112V, S119G, T124N, T125V, K156NB
 R0521R0521GQ372122None   K34R, T125V, V201I, N222Q, R262RKB
 R2504R2504GQ372127None   S17N, I72V, L101I, T112R, T124S, T125V, E157Q, K160Q, D167E, D256E, A265V, R284GB
 T1520T1520GQ372176None   V31I, S39C, A80AV, I113V, T124N, T125V, F181L, K188R, V201I, Q216N, T218I, I268L, D270NB
 T9536T9536GQ372195None   D3E, S17N, I72V, L102LF, T124N, T125V, G163EB
 X7535X7535GQ372265None   D6DE, K14R, V32I, E96D, L101I, K103R, T124N, T125V, I135V, V150VI, G193R, T206S, I208L, S230NB
Garrido (2009)5INT-5GU216852None   E11D, S24N, V31I, M50T, I72V, T125V, T206SB
 58INT-58GU216905None   E11D, S24N, V31I, M50T, I72V, T125V, T206SB
 168INT-168GU217015None   D25E, V31I, V32I, L101I, G106A, T124N, T125V, K160KR, I182V, V201IB
 204INT-204GU217051None   S17N, S39C, L45I, I113V, S119P, T124N, T125V, G163E, K211R, S230NB
 255INT-255GU217102None   S17N, V31I, I72V, K103KR, T112I, T124N, T125V, K156N, V201I, T206SB
 259INT-259GU217106None   S17N, S39C, I72IV, L101I, T124TN, T125V, I135IV, A265VB
 309INT-309GU217156None  V151IV31VI, I72V, T122I, T124N, T125V, K215N, S255SGB
 349INT-349GU217196None   E11D, V31I, M50I, V77A, K111T, S119P, T125V, S195T, I203M, T210IB
 366INT-366GU217213None   E10D, L45I, I72V, I113V, T124N, T125V, V165I, I203M, K211Q, Q216R, N254Q, S255GB
 391INT-391GU217238None   S39C, G106A, T112I, I113V, T125V, K211RB
Low (2009)B-27B-27FJ786278None   R20K, S39C, T124N, T125V, V201IB
 ahi23ahi23_96FJ786290None   K14R, S24N, A49P, L101I, T112I, T124A, T125V, V126A, T218S, N222K, R284GB
 ahi42ahi42_06FJ786309None  V54IE11D, V31I, M50I, L101I, K111T, S119G, T124N, T125V, F181L, K219Q, N222KB
 ahi54ahi54_06FJ786321None   M50T, T112M, T125V, K156R, K215N, I220L, Q221HB
 ahi67ahi67_01FJ786334None   E11D, S17T, V31I, M50I, T124N, T125V, V126M, G163E, D256EB
Nadai (2009)129696129696EU839601None   E10D, I72V, L101I, K111R, S119G, T122I, T124A, T125V, K156N, K211RB
 129389129389EU839602None   N27S, K34R, I72V, L101I, K111R, T124A, T125V, G163E, D167EB
 CRC50018CRC50018EU839607None   V31I, I72V, T125V, V165I, A205S, D232E, K244E, A265VB
 CRC50069CRC50069EU839608None   S39C, L45I, I72V, V88I, L101I, T112V, I113V, T115S, S119G, T124N, T125V, E157Q, K160E, D167E, V201I, K211R, Q221T, D256EB
Sichtig (2009)13-E13-EFJ183518None   K111Q, T112I, T124N, T125V, T206S, D256EB
 38-E38-EFJ183535None   K111T, T125V, K173RB
 47364736FJ183647None   E11D, V32I, V37I, L101I, K111Q, S119T, T124N, T125V, N222KB
 54525452FJ183668None   E11D, K14R, V31I, V32I, I73V, L101I, K111R, T112I, T124N, T125V, I161Y, L213IB
van Hal (2009)W1W1FJ554674None   E11D, V31I, T124N, T125V, T206S, Q285PB
 W2W2FJ554675None   S24D, V31I, S57C, G70E, I72V, L101I, S119R, T125V, V176L, G193E, V201I, T206S, K215N, S230N, S283GB
 W43W43FJ554716None   E11D, V31I, T124N, T125V, V176L, G193D, Q285PB
 W117W117FJ554790None  L74MT125V, D256E, V260I, K273R, S283GB
Wang (2009)PRLS19PRLS19FJ469763None   S17N, I72V, T112A, T124A, T125V, K156NB
Cuevas (2010)ES_X1958ES_X1958EU786674None   L101I, T112I, T122I, T124A, T125V, G163E, N254K, S255T, D256E, S283GB
 X2574-2X2574-2GU362886None   D6E, E10D, S24N, D25E, E35Q, S39N, L45I, I72V, S119P, T125V, K156N, Q216H, T218I, D253H, D256EB
Rangel (2010)HIV195bHIV195bGU797508None   I72V, E96D, K103R, K111H, T124N, T125V, V126M, I135V, K188R, V201I, D232EB
 HIV273pHIV273pGU797548None   L45V, M50I, I72V, I84M, E96D, T124N, T125V, V126M, I135V, A169V, D232E, G277C, R284KB
 HIV273bHIV273bGU797549None  V151IM50I, I72V, E96D, T124N, T125V, V126M, I135V, I220L, D232EB
Canducci (2011)Pt7Pt7BlJN163896None   T125V, K156N, D256EB
Kim (2011)p4p4HM051420None   E10D, V31I, L101I, T124N, T125V, G163E, D256EB
 p37p37HM051453None   E10D, V31I, L101I, T124N, T125V, G163E, D256EB
 p74p74HM051490None   F1I, E10D, V31I, L101I, T124N, T125V, G163E, D256EB
Kousiappa (2011)CY195CY195JF683747None   S39C, T112I, T124N, T125V, V201IB
 CY232CY232JF683781None  L68VS17N, I72V, I113V, T124N, T125V, G163E, T210I, K211R, D256EB
Rolland (2011)0223consensus_0223JF320059None   S17N, S39C, M50I, L101I, I113V, T124S, T125V, G134E, G163E, T218SB
 0176consensus_0176JF320363None   I72V, P90S, T124N, T125V, M154L, K173R, V201IB
 0364consensus_0364JF320559None   A38N, S39C, L45Q, I72V, T125V, I182V, V201I, D207N, K211TB
Sanabani (2011)BR1046BR1046JN692447None   D6E, S17N, I72V, T112I, T124N, T125V, G163Q, A205SB
 BR1095BR1095JN692471None   D41N, I72V, G82R, T125V, K136Q, K215NB
Brockman (2012)AEHIV72AEHIV72JQ080156None   E10D, S39C, I72V, T112I, T122I, T124N, T125V, K211RB
 AEHIV87AEHIV87JQ080171None  V54IE10D, V31I, I72V, T112I, I113V, T124N, T125V, K211R, T218IB
DeJesus (2012)75447544_1 None   S17N, V31VI, M50MI, L101I, T112TI, T124NS, T125V, G163EB
Garrido (2012)BAA295924BAA295924JQ716907None   R20K, I72V, L101I, I113L, T124N, T125V, I204V, T206SB
Iamarino (2012)BF.BR.0539BF.BR.0539JN234035None  V151IE11D, I60M, I72V, I84L, L101I, S119A, T122I, T125V, V201I, K215NB
 BF.BR.0665BF.BR.0665JN234048None   E10D, A21S, V31I, V32I, I72V, L101I, T122I, T124A, T125V, V165I, S283GB
 BF.BR.1433BF.BR.1433JN234062None   K7Q, A21S, V31I, D41N, E69D, T125V, V126M, G163E, K173E, S283GB
 B.BR.1060B.BR.1060JN234124None   E11D, D25E, V31I, I72V, L101I, K111N, T125V, I135V, Q216H, I220MB
 B.BR.1377B.BR.1377JN234144None   E11D, M50T, T124N, T125V, V126M, R187K, K211R, Y271DB
 B.BR.1461B.BR.1461JN234148None   V32I, S39C, I72V, T124N, T125V, F181Y, V201I, L234I, D253E, V259IB
Manak (2012)57_LH0157_LH01JN687675None   E11D, A21T, K34R, I72V, T125V, K211T, I220F, Q221H, D253H, A265VB
 64_LH0264_LH02JN687679None   E11D, I72V, P90S, S119T, T125VB
Molina (2012)40784078_1 None   A21T, L45V, T124Q, T125V, I182V, D256E, R262LB
 33263326_1 None   E11D, S24N, K34KR, I72IV, I84M, A91T, L101I, T125V, V201I, K211KR, S230N, R262L, S283GB
 32523252_1 None   V31I, L101I, T112I, T124A, T125V, I135V, G163QH, A179G, F181L, V201I, T206S, L234I, D256E, I268L, D270HB
 41564156_1 None   D6E, S17N, V31I, T112IV, T124N, T125V, L158F, H171HQ, D232E, A265VB
 30533053_1 None   V31I, T124TN, T125V, K156N, D167EB
Rolland (2012)AA011a09LAA011a09LJX446807None   E11D, K14R, R20K, L28I, V31I, M50I, K111T, T125V, K211R, E212E_GERIVDIIA, L234I, D253EB
Capel (2013)9999KC238625None   S24T, E92X, K111R, T125V, D232E, A265VB
 113113KC238639None   N27S, L28I, V31I, L45Q, I113V, S119G, T124N, T125V, G163X, L234IB
 137137KC238661None   E10D, I72V, T112I, T125V, M154I, V165I, V201IB
 131131KC238655None   L28I, M50I, T112X, T125V, I208LB
 7171KC238605None   S17N, I72V, T125V, K156N, I208L, D256E, S283XB
 8181KC238610None   E11D, S24N, V31I, M50I, T125V, T206S, A265VB
Li (2013)28262826JQ901040None   S17N, I72V, A91G, L101I, T124A, T125V, K156N, D167E, V201IB
Reigadas (2013)2929JX425497None   E11D, K14R, V32I, S39C, M50I, A91T, L101I, T125V, I135V, K136N, V201I, K240RB
 3232JX425500None   V31I, L101M, T112V, T124N, T125V, V201I, K215N, D256E, A265VB
 4545JX425513None   E11D, S17T, M50T, L101I, T124N, T125V, G163E, E212A, D256EB
 4848JX425516None   I72V, T124A, T125V, E198D, V201I, K215N, N222HB
 5454JX425522None   E11D, V31I, I72V, L101I, I113V, S119G, T125VB
 6666JX425534None   S17N, V31I, L101I, T112I, T124N, T125V, K156N, D256EB
 6767JX425535None   E10D, I113V, T124N, T125V, I220M, D253EB
 7575JX425543None   A23V, L28I, V37I, S39C, K111R, T112A, T124N, T125V, N254KB
 9191JX425559None   K7KR, S39C, M50I, T125V, G193E, V201IB
 100100JX425568None   S17N, V31I, L45V, K111R, I113V, T124N, T125V, G163E, R187R_NILKQQYKW, K211R, D256E, V281M, Q285PB
 106106JX425574None   R20K, S39C, T125V, V201I, Q221QKB
 135135JX425603None   S17N, I72V, A91S, L101I, T112I, T125V, K160H, D256EB
 144144JX425612None  T97AE11D, V31I, K34R, L101I, T112V, T125V, K215N, D256EB
 164164JX425631None   I72V, S119G, T124N, T125V, V201VI, A265V, S283SGB
 170170JX425637None   E11D, K14R, A21T, S39C, M50MI, L63LQ, T124N, T125VB
 174174JX425641None   V31I, I72V, T112I, T122I, T124TADN, T125V, K127KR, G163E, K211RB
 189189JX425656None   L101I, K111R, T112I, S119T, T125V, V201I, I208L, D232EB
 231231JX425698None   S119G, T124N, T125V, K156N, Q216N, I220L, Q221H, L234F, V281MB
 245245JX425712None   S24G, I72V, T125V, K160TB
 1801318013JX451889None   E13G, I72V, T122I, T124N, T125V, A265VB
Chikata (2014)KI-993KI-993AB874265None   T125V, K156N, I203MB
 KI-962KI-962AB874246None   S17N, L28I, L45V, L101I, I113V, T124A, T125V, G163E, Q216H, L234LI, D253DEB
 KI-445KI-445AB873912None   E10D, V31I, V32I, D41N, L101I, I113V, T124A, T125V, G163E, V201I, T206S, Q216HB
 KI-763KI-763AB874090None   S17N, L101I, I113V, T124A, T125V, G163E, V201I, A205AS, Q216HB
 KI-539KI-539AB873977None   E11D, S24N, V31I, L45V, L101IV, T124TA, T125V, G163E, T206S, D256DEB
 KI-623KI-623AB873923None   S17N, V31I, L101I, T124A, T125V, G163E, T206S, Q216NB
Martin (2014)ACU48ACU48KJ869657None   D6E, K7R, T124N, T125V, D256EB
 ACU43ACU43KJ869652None   I60V, T112I, I113V, S119T, T124N, T125V, T218S, M275V, S283GB
 ACU27ACU27KJ869636None   S17N, L101I, T125V, G163E, I220VB
 ACU66ACU66KJ869675None   E11D, S24N, T112V, T124N, T125V, V201IB
 ACU72ACU72KJ869681None   E11D, I60M, T112I, T124N, T125V, F181L, T206S, K219N, N222K, S255GB
Stekler (2014)PIC1812PGA49PIC1812PGA49 None   E11D, V31I, K111T, T122I, T125V, I208L, K211RB
 PIC1790PFQ52PIC1790PFQ52 None   D6E, E10D, S39C, I72V, L101I, S119G, T122I, T124A, T125V, Q216H, T218S, R284GB
 PIC1789PFQ49PIC1789PFQ49 None   D6E, E10D, S39C, I72V, L101I, S119G, T122I, T124A, T125V, Q216H, T218S, R284GB
 PIC1795PFW49PIC1795PFW49 None   I72V, K111T, T112A, S119T, T125V, S283GB
 PIC1792PFD54PIC1792PFD54 None   R20K, L101I, T112V, S119P, T125V, G163E, L234IB
 PIC1793PFQ53PIC1793PFQ53 None   E11D, A38N, S39C, L45Q, I72V, S119G, T125V, I182V, V201I, D207N, K211TB
 PIC1904PGX56PIC1904PGX56 None   E11D, A21T, A38N, S39C, L45Q, I72V, T124A, T125V, I182V, V201I, D207N, K211TB
 ACTU9201PHI57ACTU9201PHI57 None   E11D, A21T, A38N, S39C, L45Q, I72V, L101I, T125V, I182V, V201I, D207N, K211TB
 PIC1856PGK53PIC1856PGK53 None   E11D, V31I, K111T, S119G, T125V, I208LB
 PIC1777PFD49PIC1777PFD49 None   E11D, D25E, L28I, S39C, I60V, Y99F, L101I, K111T, T112V, I113V, T124N, T125V, I135VB
Hachiya (2015)N0882N0882LC022559None  V54ILS17N, S24SAGT, K111KR, T124N, T125V, K188RB
 92309230LC022391None  T97TAS17N, V31VI, L101I, I113IV, T124A, T125V, G163E, V201I, Q216NB
 N288N288LC022654None   V31I, L101I, K111T, S119T, T124N, T125V, I135V, V201I, T206S, I217S, Q221K, S230NB
Hora (2015)DEMB08UY001DEMB08UY001JX140655None   D6E, E10D, S24N, D25E, E35Q, S39N, L45I, I72V, S119P, T125V, K156N, Q216H, T218I, D253H, D256EB
 DEMB13ES010DEMB13ES010KP109518None   D6E, E11D, S17N, S39C, M50I, I72V, L101I, T112I, T124N, T125V, G163E, A175V, K211R, T218S, Y227F, D256EB
 DEMB10VE001DEMB10VE001JX140659None   D6E, E10D, S24N, D25E, E35Q, S39N, L45I, I72V, S119P, T125V, K156N, K173E, I208L, K211R, Q216H, T218I, D253H, D256EB
Kinloch (2015)INT_179INT_179KT167738None   I72V, T124N, T125V, A265VB
 INT_31INT_31KT167590None   T124N, T125V, A265V, D278DEB
 INT_125INT_125KT167684None   S17N, V31I, I72V, L101I, T122I, T124A, T125V, G163EB
 INT_148INT_148KT167707None   I72V, T124TA, T125V, D167E, N254KB
 INT_17INT_17KT167576None   S17N, V32I, S39C, I72V, I113V, T124N, T125V, N222K, S230SN, V259I, A265AVB
 INT_138INT_138KT167697None  V151VIS24SG, S39C, L45LI, I72V, T112I, T124N, T125VB
 INT_114INT_114KT167673None  V151IE11D, S24N, M50L, I72V, L101I, S119G, T125V, V201I, N222QB
Pessoa (2015)10BR_MG035MG035KJ849804None  L74M, V151IS17N, M50I, I72V, I113L, S119P, T124N, T125V, G193D, S195T, T218I, S255N, D278SB
 10BR_SP042SP042KJ849806None   K14R, R20K, L101I, K111T, S119P, T125V, I135V, T206S, I220L, S230N, D256EB
Pessoa (2016)10BR_MG02210BR_MG022KT427834None   I72V, T125V, K156R, K211R, K215NB
 10BR_MG04410BR_MG044KT427671None   E11D, L28I, V37I, S39C, G106A, T112V, S119G, T125V, H171Q, V201I, S283GB
 10BR_MG04110BR_MG041KT427673None   E10D, S24G, L28I, M50I, I72V, S119P, T124N, T125V, D253E, D256EB
 10BR_SP00710BR_SP007KT427826None   S17N, S39C, L74I, T124A, T125V, D167E, V201I, I208L, D256EB
 10BR_SP05110BR_SP051KT427803None   S39C, I72V, T125V, D253EB
 10BR_MG01510BR_MG015KT427832None   D6E, E11D, K14R, V32I, S39C, M50I, P90A, L101I, T124A, T125V, V201I, T218S, Y227FB