Integrase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	T125V
Rx	II-naive
IncludeMixtures	No

References	27
Patients	96
Isolates	96

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	INIMinorDRMs	OtherMut	Subtype
McLaughlin (2004)	98USHVTN8229c6	98_8229c6	AY560109	None		L101I, T124N, T125V, I135V, D167E, I208L, K211Q, D232E, D256E	B
	98USHVTN941c1	98_941c1	AY560110	None		S24A, D25N, S119T, T124N, T125V, E198D, V201I, T206S, D256E	B
Saad (2005)	SM_02YE519	02YE519	AY795908	None		E11D, A23V, S24N, I72V, L101I, T125V, K156R, E157Q, K160Q, K215N, D253E	B
Sanchez (2006)	PCM034	PCM034	AY561238	None		V31I, G70R, I72V, K111R, I113V, T125V, G134E, R187K, K188R, Y227F, L234V, D253E	B
Zarandia (2006)	98GEMZ001	98GEMZ001	DQ207940	None		D6E, E13D, I73V, L101I, T112I, T124A, T125V, S153T, Q216H	B
Andresen (2007)	PMVL 013	PMVL 013	EF514700	None		E11D, A23V, I73V, L101I, K111R, T112I, S119G, T124Q, T125V, V201I, S283N	B
	CTL 030	CTL 030	EF514708	None		D6E, E10D, I72V, G106A, T122TI, T124N, T125V	B
Lataillade (2007)	482-009	ML_482-009	EF472722	None		S17N, M50IT, I72V, S123SG, T124A, T125V, G163E, Y227F, D253HY, S255N, D256E	B
	482-079	ML_482-079	EF472724	None		S17N, T124N, T125V, I135V, G163E, V201I, N254Q, D256E	B
	63B	ML_63B	EF472784	None		S17N, T124N, T125V, I135V, G163E, V201I, N254Q, D256E	B
Sa-Filho (2007)	BREPM1032	BREPM1032	EF637051	None	V151I	E10D, M50I, I72V, S119T, T125V, K173R, S255N	B
Struck (2007)	luBF_21.06	luBF_21.06	EU170137	None		E11D, R20K, L28I, V37I, S39C, V77A, I84L, L101I, T124A, T125V, G163GE, V180VI, V201I, Q216QH, N222H, L234V	B
	luBF_10.03	luBF_10.03	EU170149	None		E11D, R20K, L28I, V37I, S39C, I72V, I84L, L101I, T125V, G163E, V201I, L234V	B
	luBF_03.03	luBF_03.03	EU170152	None		E11D, R20K, L28I, V37I, S39C, I84L, L101I, T124TS, T125V, G163E, V201I, L234V	B
Buzon (2008)	Pt40	Pt40Y1995	EU883903	None		E11D, M50MI, I72V, K111Q, T112V, S119AG, T124N, T125V	B
Miura (2008)	BEC110	BEC110	EU517860	None		R20RK, S39C, L45Q, I72V, T125V, I220IV, I268L, S283SG	B
	BEC36	BEC36	EU517868	None	V151I	L28I, I72V, T125V, I220M, Q221H, A265V	B
	BEC78	BEC78	EU517888	None		S17N, V31I, I72V, I84L, T112A, T124N, T125V, D232E, A265V	B
	BEC108	BEC108	EU517891	None		E10A, T124N, T125V, G163E, K211R, Q252L	B
Brumme (2009)	INT_3500	INT_3500	FJ812951	None		E11D, S24N, S39C, I72IV, L101I, T124TA, T125V, E157D, V201VI	B
	INT_3512	INT_3512	FJ812963	None		T125V, S230N	B
	INT_3584	INT_3584	FJ813035	None		E11D, I72V, S119AGPR, T122TI, T124TN, T125V, M154L, T218TI, I220L, Q221H	B
	INT_3622	INT_3622	FJ813073	None		S24SN, D25E, V77I, I84M, L101I, S119T, T124N, T125V, V165I, K173KR	B
	INT_3631	INT_3631	FJ813082	None		E11D, S17T, I60M, I72V, T124N, T125V, V150A, D167E	B
	INT_3744	INT_3744	FJ813195	None		E10D, S39C, I72V, T112I, T122I, T124N, T125V, K211R	B
	INT_3781	INT_3781	FJ813232	None		V31VIM, I72V, S119P, T124TN, T125V, V126L, I135IV, A265V, D279DG	B
	INT_3788	INT_3788	FJ813239	None		T124TN, T125V, K156N, I162V, V201VI	B
	INT_3840	INT_3840	FJ813291	None		E11D, I72V, S119P, T122I, T125V, V201I, K211Q	B
	INT_3896	INT_3896	FJ813347	None		S17N, I72IV, T125V, G163E	B
	INT_4027	INT_4027	FJ813478	None		K7R, E11D, D25E, L28I, S39C, I72V, I113V, T124Q, T125V, I182V, Q216H, L234F	B
	B1542	B1542	GQ371793	None		E10D, M50T, I72V, T112I, I113V, T124S, T125V, R187RK, D256E	B
	E7538	E7538	GQ371856	None		K7R, S17N, T124N, T125V, I135V, V201I, T206S, I208L, I220M, Q221G	B
	F3507	F3507	GQ371866	None		K7R, S17N, M50L, I72V, T112V, I113V, T125V	B
	G8521	G8521	GQ371903	None		I72V, K111R, T112I, T125V, I141V, K160R, D167E, V201I, T206S, I220V	B
	J4531	J4531	GQ371941	None		S17N, L101I, I113V, T125V, G163E, H171Q, D256E	B
	J5505	J5505	GQ371942	None		E11D, V31I, V37I, I72V, L101I, K111RT, S119SAGT, T124N, T125V, I135V, D167E, V201I, Q216N, I220M, V281M	B
	K6538	K6538	GQ371966	None		S17N, V31I, I72V, L101I, S119G, T122V, T124A, T125V, K156N, I182V, V201I	B
	K9548	K9548	GQ371974	None		S17N, R20K, K34R, M50I, I72V, T112A, T125V, V165I, V201I, K211R, S230N, D256E, K266KR	B
	O0539	O0539	GQ372049	None		E10D, E11D, V31I, I113V, T124N, T125V, Q216N, I220M	B
	P6501	P6501	GQ372089	None		D6E, E10D, V31I, T112V, S119G, T124N, T125V, K156N	B
	R0521	R0521	GQ372122	None		K34R, T125V, V201I, N222Q, R262RK	B
	R2504	R2504	GQ372127	None		S17N, I72V, L101I, T112R, T124S, T125V, E157Q, K160Q, D167E, D256E, A265V, R284G	B
	T1520	T1520	GQ372176	None		V31I, S39C, A80AV, I113V, T124N, T125V, F181L, K188R, V201I, Q216N, T218I, I268L, D270N	B
	T9536	T9536	GQ372195	None		D3E, S17N, I72V, L102LF, T124N, T125V, G163E	B
	X7535	X7535	GQ372265	None		D6DE, K14R, V32I, E96D, L101I, K103R, T124N, T125V, I135V, V150VI, G193R, T206S, I208L, S230N	B
Garrido (2009)	5	INT-5	GU216852	None		E11D, S24N, V31I, M50T, I72V, T125V, T206S	B
	58	INT-58	GU216905	None		E11D, S24N, V31I, M50T, I72V, T125V, T206S	B
	168	INT-168	GU217015	None		D25E, V31I, V32I, L101I, G106A, T124N, T125V, K160KR, I182V, V201I	B
	204	INT-204	GU217051	None		S17N, S39C, L45I, I113V, S119P, T124N, T125V, G163E, K211R, S230N	B
	255	INT-255	GU217102	None		S17N, V31I, I72V, K103KR, T112I, T124N, T125V, K156N, V201I, T206S	B
	259	INT-259	GU217106	None		S17N, S39C, I72IV, L101I, T124TN, T125V, I135IV, A265V	B
	309	INT-309	GU217156	None	V151I	V31VI, I72V, T122I, T124N, T125V, K215N, S255SG	B
	349	INT-349	GU217196	None		E11D, V31I, M50I, V77A, K111T, S119P, T125V, S195T, I203M, T210I	B
	366	INT-366	GU217213	None		E10D, L45I, I72V, I113V, T124N, T125V, V165I, I203M, K211Q, Q216R, N254Q, S255G	B
	391	INT-391	GU217238	None		S39C, G106A, T112I, I113V, T125V, K211R	B
Kousiappa (2009)	CY036	CY036	FJ388959	None		S17N, L101I, T124A, T125V, I141V, I220L, Y227F, A265V	B
Low (2009)	B-27	B-27	FJ786278	None		R20K, S39C, T124N, T125V, V201I	B
	ahi23	ahi23_96	FJ786290	None		K14R, S24N, A49P, L101I, T112I, T124A, T125V, V126A, T218S, N222K, R284G	B
	ahi42	ahi42_06	FJ786309	None	V54I	E11D, V31I, M50I, L101I, K111T, S119G, T124N, T125V, F181L, K219Q, N222K	B
	ahi54	ahi54_06	FJ786321	None		M50T, T112M, T125V, K156R, K215N, I220L, Q221H	B
	ahi67	ahi67_01	FJ786334	None		E11D, S17T, V31I, M50I, T124N, T125V, V126M, G163E, D256E	B
Nadai (2009)	129696	129696	EU839601	None		E10D, I72V, L101I, K111R, S119G, T122I, T124A, T125V, K156N, K211R	B
	129389	129389	EU839602	None		N27S, K34R, I72V, L101I, K111R, T124A, T125V, G163E, D167E	B
	CRC50018	CRC50018	EU839607	None		V31I, I72V, T125V, V165I, A205S, D232E, K244E, A265V	B
	CRC50069	CRC50069	EU839608	None		S39C, L45I, I72V, V88I, L101I, T112V, I113V, T115S, S119G, T124N, T125V, E157Q, K160E, D167E, V201I, K211R, Q221T, D256E	B
Sichtig (2009)	13-E	13-E	FJ183518	None		K111Q, T112I, T124N, T125V, T206S, D256E	B
	38-E	38-E	FJ183535	None		K111T, T125V, K173R	B
	4736	4736	FJ183647	None		E11D, V32I, V37I, L101I, K111Q, S119T, T124N, T125V, N222K	B
	5452	5452	FJ183668	None		E11D, K14R, V31I, V32I, I73V, L101I, K111R, T112I, T124N, T125V, I161Y, L213I	B
van Hal (2009)	W1	W1	FJ554674	None		E11D, V31I, T124N, T125V, T206S, Q285P	B
	W2	W2	FJ554675	None		S24D, V31I, S57C, G70E, I72V, L101I, S119R, T125V, V176L, G193E, V201I, T206S, K215N, S230N, S283G	B
	W43	W43	FJ554716	None		E11D, V31I, T124N, T125V, V176L, G193D, Q285P	B
	W117	W117	FJ554790	None	L74M	T125V, D256E, V260I, K273R, S283G	B
Wang (2009)	PRLS19	PRLS19	FJ469763	None		S17N, I72V, T112A, T124A, T125V, K156N	B
Rangel (2010)	HIV195b	HIV195b	GU797508	None		I72V, E96D, K103R, K111H, T124N, T125V, V126M, I135V, K188R, V201I, D232E	B
	HIV273p	HIV273p	GU797548	None		L45V, M50I, I72V, I84M, E96D, T124N, T125V, V126M, I135V, A169V, D232E, G277C, R284K	B
	HIV273b	HIV273b	GU797549	None	V151I	M50I, I72V, E96D, T124N, T125V, V126M, I135V, I220L, D232E	B
Kim (2011)	p4	p4	HM051420	None		E10D, V31I, L101I, T124N, T125V, G163E, D256E	B
	p37	p37	HM051453	None		E10D, V31I, L101I, T124N, T125V, G163E, D256E	B
	p74	p74	HM051490	None		E10D, V31I, L101I, T124N, T125V, G163E, D256E	B
Rolland (2011)	0223	consensus_0223	JF320059	None		S17N, S39C, M50I, L101I, I113V, T124S, T125V, G134E, G163E, T218S	B
	0176	consensus_0176	JF320363	None		I72V, P90S, T124N, T125V, M154L, K173R, V201I	B
	0364	consensus_0364	JF320559	None		A38N, S39C, L45Q, I72V, T125V, I182V, V201I, D207N, K211T	B
Sanabani (2011)	BR1046	BR1046	JN692447	None		D6E, S17N, I72V, T112I, T124N, T125V, G163Q, A205S	B
	BR1095	BR1095	JN692471	None		D41N, I72V, G82R, T125V, K136Q, K215N	B
Brockman (2012)	AEHIV72	AEHIV72	JQ080156	None		E10D, S39C, I72V, T112I, T122I, T124N, T125V, K211R	B
	AEHIV87	AEHIV87	JQ080171	None	V54I	E10D, V31I, I72V, T112I, I113V, T124N, T125V, K211R, T218I	B
Garrido (2012)	BAA295924	BAA295924	JQ716907	None		R20K, I72V, L101I, I113L, T124N, T125V, I204V, T206S	B
Iamarino (2012)	BF.BR.0539	BF.BR.0539	JN234035	None	V151I	E11D, I60M, I72V, I84L, L101I, S119A, T122I, T125V, V201I, K215N	B
	BF.BR.0665	BF.BR.0665	JN234048	None		E10D, A21S, V31I, V32I, I72V, L101I, T122I, T124A, T125V, V165I, S283G	B
	BF.BR.1433	BF.BR.1433	JN234062	None		K7Q, A21S, V31I, D41N, E69D, T125V, V126M, G163E, K173E, S283G	B
	B.BR.1060	B.BR.1060	JN234124	None		E11D, D25E, V31I, I72V, L101I, K111N, T125V, I135V, Q216H, I220M	B
	B.BR.1377	B.BR.1377	JN234144	None		E11D, M50T, T124N, T125V, V126M, R187K, K211R, Y271D	B
	B.BR.1461	B.BR.1461	JN234148	None		V32I, S39C, I72V, T124N, T125V, F181Y, V201I, L234I, D253E, V259I	B
Rolland (2012)	AA011a09L	AA011a09L	JX446807	None		E11D, K14R, R20K, L28I, V31I, M50I, K111T, T125V, K211R, E212E_GERIVDIIA, L234I, D253E	B
Li (2013)	2826	2826	JQ901040	None		S17N, I72V, A91G, L101I, T124A, T125V, K156N, D167E, V201I	B

Integrase Inhibitors

Database

Resources

Team