<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation T125S
Rx II-naive
IncludeMixtures No
References 22
Patients 110
Isolates 111
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Graf (1998)RL42RL42U71182None  N155DS17C, S119R, T124N, T125S, K211R, D229G, A265VB
Tovanabutra (2001)NP1623NP1623AF362994None   E11D, S17C, A91T, L101I, S119R, T125S, V165I, K211R, S230N, L241P, A265VB
Su (2003)02HNsc1102HNsc11AY275556None  L68IA91T, L101I, K111R, S119R, T124N, T125S, K156N, V165I, Y194T, S195C, K211RB
Swanson (2003)TH1600TH1600AY214058None   S17C, S119R, T124N, T125S, G163E, K211R, I220V, K236KR, A265VB
Takebe (2003)TY_pat4TYmSTD101AB097870None   D6E, E11D, S17C, V31I, A91T, L101I, S119R, T124N, T125S, I162V, G163E, K173E, K188E, K211R, S230NB
 TY_pat9TYmIDU502AB097865None   D6X, S17N, E35G, T112I, S119R, T124N, T125S, G163E, K211RB
Liu (2005)02HNsc1102HNsc11DQ007903None  L68IA91T, L101I, K111R, S119R, T124N, T125S, K156N, V165I, Y194T, S195C, K211RB
Qiu (2005)YNRL9828YNRL9828AY967805None   S17C, K71N, S119R, T124N, T125S, V165I, K211R, L234I, R269K, K273T, D278A, S283GB
 YNRL9607YNRL9607AY967804None   S17C, S119R, T124N, T125S, K211R, S230N, L234I, A265VB
Tee (2006)KL01904_019.1DQ366665None   A91T, S119R, T125S, L234IB
Watanaveeradej (2006)00TH_C319800_C3198AY945710None   A91T, S119R, T124N, T125S, F185Y, K211RB
Brumme (2009)INT_3474INT_3474FJ812925None   E11D, L101I, K111T, S119P, T122I, T124TA, T125S, T218TS, D256EB
 INT_3787INT_3787FJ813238None   K7Q, V31VI, I72V, K111T, S119P, T122I, T124A, T125S, V201I, S230SNB
Garrido (2009)68INT-68GU216915None   A33AG, M50I, C56CW, K111T, S119R, T125SB
 113INT-113GU216960None   L28I, V37I, L101I, S119P, T122I, T125S, S230N, D256EB
 215INT-215GU217062None   E11D, S24A, V31I, A91T, L101I, S119R, T125S, T206S, I208L, T210S, K211S, E212I, T218S, D232E, D256EB
Sichtig (2009)720720FJ183498None   L101I, T112I, I113V, S119P, T122I, T124A, T125S, I135IV, V201IB
van Hal (2009)W38W38FJ554711None   V31I, I72V, L101I, T112I, S119G, T122I, T124A, T125S, G193E, V201I, L234V, R269K, D278NB
 W55W55FJ554728None   E10D, E13D, V31I, S39N, S119T, T124A, T125S, K188R, G193E, V201I, A265VB
 W127W127FJ554800None   R20K, V31I, I72V, L101I, T112I, S119G, T122I, T124A, T125S, G193E, V201I, L234V, R269K, D278NB
Rangel (2010)HIV268bHIV268bGU797541None   S119R, T125S, D253E, D256EB
Brenner (2011)76517651HQ207760None   E11D, V31I, L101I, K111T, S119P, T122I, T124A, T125S, V201I, I203M, I208M, D256EB
Wilantho A (2011)711206711206JF928889None   S17C, L28LI, L45V, A91T, S119R, T124N, T125S, V165I, K211R, N222H, A265VB
 SL007SL007JF928931None   S17SN, S119K, T124N, T125S, L234IB
 711217711217JF928894None   V31VI, V88I, A91T, L101I, S119R, T124N, T125S, L158LF, G163E, K211R, K215KNB
 514638514638JF928916None   S17C, L28LI, L45V, A91T, S119R, T124N, T125S, V165I, K211R, N222H, A265VB
 804233804233JF928984None   S17SN, R20RK, G70E, L101I, K111R, S119R, T124N, T125S, V201I, K211R, S230N, A265AVB
Rolland (2012)AA040a_WG13AA040a_WG13JX447158None E138KT97AG70E, L101I, S119R, T124N, T125S, M154I, K211RB
Zeng (2012)CN1337CN1337JQ028390None  L68IK7R, M50I, I73V, V88I, A91T, L101I, K111R, S119R, T125S, K156N, K211RB
Kijak (2013)05TH42973005TH429730JN248347None   K71Q, S119R, T125S, F181L, I203M, K211R, S230N, A265VB
 05TH44024805TH440248JN248348None   S17N, L28I, G70E, L101I, T112M, S119R, T124N, T125S, K211RB
 04TH60106604TH601066JN248329None   V31I, I89M, L101I, S119R, T124N, T125S, K156N, E157Q, K160T, S230NB
 04TH80899804TH808998JN248335None   K14R, A91T, I113V, S119R, T125S, S195N, K211R, R231K, L234V, Q285QRB
Li (2013)21252125JQ302625None   S17N, S119R, T124N, T125S, K173R, K211R, T218I, L234I, A265VB
 20122012JQ302552None   E11D, S17C, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211RB
 21262126JQ302626None   S17N, S119R, T124N, T125S, K173R, K211R, T218I, L234I, A265VB
Li (2013)hnhy79hnhy79KC988122None   S17N, N27S, L28I, A38T, S39C, L45I, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211RB
 hnsy17hnsy17KC988134None  L68IL28I, L45I, V88I, A91T, L101I, S119R, T125S, K156N, K211R, D278N, R284GB
 hnxx198hnxx198KC988160None  L68VV88I, A91T, L101I, K111KR, S119R, T124N, T125S, K156N, K211R, D286NB
 hnxx100hnxx100KC988156None  L68VV88I, A91T, L101I, S119R, T124N, T125S, K156N, K211R, D278N, C280SB
 hnhy73hnhy73KC988120None   S17C, M50I, L68E, I72V, A91T, L101I, S119R, T124N, T125S, K156N, I203M, K211RB
 hnqx108hnqx108KC988065None   S17N, V88I, A91T, L101I, S119R, T125S, K156N, K211RB
 hnsy8hnsy8KC987987None   S17N, N27G, L28I, P30A, L45I, V88I, A91T, L101I, S119R, T125S, K156N, V201I, K211RB
 hnhy63hnhy63KC988118None  L68IE10D, I60M, A91T, L101I, K111R, S119R, T124N, T125S, K156N, K211R, S230NB
 hnxx199hnxx199KC988109None   S17N, K71Q, V88I, L101I, S119R, T124N, T125S, K156N, A205S, K211R, R263G, K264N, R269VB
 hntk12hntk12KC987970None   S17S_F, V88I, A91T, Q95P, L101I, S119R, T124N, T125S, K136N, K156N, K211R, S230NB
 hnsx38hnsx38KC988132None   D6E, E13D, S17N, L68A, K71Q, L101I, S119R, T124N, T125S, K156N, P261SB
 hnr121hnr121KC988071None  L68VK71Q, A91T, L101I, S119R, T124N, T125S, K156N, T218I, L234I, D278NB
 hnsy51hnsy51KC988136None  L68VV88I, A91T, L101I, S119R, T124N, T125S, K156N, K188R, K211R, D278EB
 hnsy24hnsy24KC988135None  L68VE11D, S17C, A91T, L101I, S119R, T124N, T125S, K156N, V165I, K211RB
 hnwsx69hnwsx69KC988073None  L68VV88I, A91T, L101I, K111R, S119R, T125S, K156N, V176L, K211RB
 hnxx197hnxx197KC988159None  L68VV88I, A91T, L101I, S119R, T124N, T125S, K211RB
 hnsy69hnsy69KC988139None  L68VV88I, A91T, L101I, S119R, T122I, T124N, T125S, K156N, V176L, K211RB
 hnsx31hnsx31KC987977None   S17N, L28I, V37A, L45I, V88I, A91T, E96D, L101I, S119R, T124N, T125S, K156N, K211R, R269KB
 hnsx29hnsx29KC987978None  L68VV88I, A91T, L101I, S119R, T125S, K156N, K211RB
 hnsy5hnsy5KC988166None   E10D, L68M, A91T, L101I, S119R, T122A, T124N, T125S, G149A, K156N, K211R, N222H, I257TB
 hnhy37hnhy37KC987985None  L68VV88I, A91T, L101I, S119R, T125S, K156N, K211RB
 hnqx89hnqx89KC987968None  L68IMH12H_EN, E13D, K14R, S17C, V88I, A91T, L101I, S119R, T124N, T125S, A133AT, Q137QH, K156N, K211R, N222H, D278NB
 hnsx25hnsx25KC988129None   E11D, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211RB
 hnsy16hnsy16KC987989None  L68VI60M, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211R, D278NB
 hnwsx34hnwsx34KC988140None  L68VV88I, A91T, L101I, S119R, T124N, T125S, K156N, K211RB
 hnhy85hnhy85KC988125None   L68A, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211RB
 hnxx123hnxx123KC988157None  L68VS17C, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211R, A265V, D286NB
 hnhy67hnhy67KC988121None  L68VL28I, S39C, L45I, V88I, A91T, L101I, K111R, S119R, T124N, T125S, K156N, K211RB
 hnsy28hnsy28KC988162None  L68VM50I, A91T, L101I, S119R, T125S, K156N, K211RB
 hnxx3hnxx3KC988116None   S17N, V88I, A91T, L101I, S119R, T125S, K156N, K211R, D256EB
 hnwsx37hnwsx37KC988141None  L68VR20K, V88I, L101I, S119R, T124N, T125S, K156N, K188R, K211RB
 hnhy72hnhy72KC988115None   S17N, V88I, A91T, L101I, A105AS, S119R, T124N, T125S, K156N, L172F, V201I, K211R, D278NB
 hnxx96hnxx96KC988155None  L68VA91T, L101I, S119R, T125S, K156N, K211RB
 hnqx110hnqx110KC988066None   E13D, L28I, L45I, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K160T, K211RB
 hnsy9hnsy9KC987984None  L68IE11D, S17C, A91T, L101I, S119R, T124N, T125S, K156N, V165I, L172F, K211RB
 hnxx200hnxx200KC988113None   S17N, V88I, E96D, L101I, S119R, T124N, T125S, K156N, K211RB
 hnwsx51hnwsx51KC988148None  G163RE10D, L68E, A91T, L101I, S119R, T124N, T125S, K156N, K211R, I220V, D256EB
 hnqx88hnqx88KC987969None  L68VE11D, Y15YF, H16HCRY, S17C, A91T, L101I, S119R, T124N, T125S, Q137H, G163E, K211RB
 hnr142hnr142KC988072None   K14R, A23V, S24G, L28I, L68A, A91S, L101I, S119R, T125S, K156N, K211R, D279GB
 hnsy2hnsy2KC987975None   E13D, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211RB
 hnsy20hnsy20KC987976None  L68VI73V, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211RB
 hnhy39hnhy39KC988117None   K7R, K14R, L28I, V88I, A91T, L101I, S119R, T125S, K156N, K211RB
 hnr3hnr3KC988067None   S17N, N27S, L28I, S39C, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211RB
 hnxx45hnxx45KC988149None   S17N, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211RB
 hnsx41hnsx41KC988133None  L68VK14R, L28I, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211RB
 hnkfx67hnkfx67KC988062None   K7R, E13D, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211R, D256E, D278NB
 hnxx254hnxx254KC988161None   V88I, A91T, L101I, K103R, S119R, T124N, T125S, K156N, I200M, V201I, D286NB
 hnxx74hnxx74KC988153None   V88I, A91N, L101I, K111R, S119R, T125S, K156NB
 hnhy91hnhy91KC988127None   S17N, L28I, L45I, K71Q, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211R, S283GB
 hnsy6hnsy6KC987982None   S17N, V88VI, A91T, L101I, S119R, T125S, K156N, K211RB
 hnsx34hnsx34KC987981None  L68VV88I, A91S, L101I, T112I, S119R, T124N, T125S, K156N, K211R, S230NB
 hnsy48hnsy48KC988167None  L68VV88I, A91T, L101I, S119R, T124N, T125S, K156N, R187K, K188R, K211R, S283GB
 hnsx33hnsx33KC987980None  L68VE11D, S17C, V88I, L101I, S119G, T122I, T124N, T125S, K156N, K211RB
 hnxy27hnxy27KC988074None  T97AV88I, A91T, L101I, K111R, S119R, T124N, T125S, K156N, K188R, K211RB
 hnr19hnr19KC988163None   K14R, V88I, A91T, L101I, K111R, S119K, T124N, T125S, K156N, V165A, K211R, N222H, S230N, I268TB
 hnr68hnr68KC988070None  L68VS17N, L28I, L45I, K71Q, V88I, L101I, S119R, T125S, A133T, K156N, K211RB
 hnkfx84hnkfx84KC988063None   S17N, V31I, A76T, A91T, L101I, S119R, T124N, T125S, K156N, V165I, K211RB
 hnr14hnr14KC988068None  L68VM50I, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K188R, K211RB
 hnhy80hnhy80KC988123None   E11D, S17C, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211R, D278NB
 hnr25hnr25KC988069None   D25E, M50V, V88I, A91T, L101I, S119R, T124N, T125S, C130Y, K156N, K211R, L234HB
 hnxx64hnxx64KC988151None   S17N, L68M, V88I, A91T, L101I, S119R, T125S, K156N, K211RB
 hnsy49hnsy49KC987988None  L68VV88I, A91T, L101I, S119R, T124N, T125S, S153A, K156N, K211RB
 hnhy64hnhy64KC988110None   S17N, L45I, V88I, A91S, L101I, S119R, T122A, T125S, K156N, K211RB
 hnsx37hnsx37KC988131None  L68VE11D, G70E, V88I, L101I, T112I, S119R, T124N, T125S, K156N, K211RB
 hnhy90hnhy90KC988126None   S17C, L68A, K71Q, V88I, L101I, S119R, T124N, T125S, K156N, K211R, I220L, D278NB
 hnwsx44hnwsx44KC988146None  L68LVQ53H, V88I, A91T, L101I, K111R, S119R, T124N, T125S, K211R, S283GB
 hnr141hnr141KC988164None  L68VV88I, A91T, L101I, W108*, S119R, T124N, T125S, G163E, V201I, I208M, K211R, E212AB
 hntk4hntk4KC988075None   K7R, V88I, A91T, L101I, S119R, T124N, T125S, G134GE, F139FC, K156N, K211RB
 hnsy57hnsy57KC988137None  L68VE10D, S17C, A91T, L101I, S119R, T125S, K156N, V165I, K211R, D256E, D278GB
 hnsx36hnsx36KC987974None   V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211R, D279GB
 hnxx188hnxx188KC988158None   S17C, V88I, A91T, L101I, T112A, S119R, T124N, T125S, K156N, F181L, I208M, K211R, E212AB
 hnr143hnr143KC987971None   L28I, S39C, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211R, S255S_GB
 hnsx30hnsx30KC987986None  L68VL28I, L45V, V88I, A91T, L101I, S119R, T124N, T125S, K156N, K211R, S283GB
Stekler (2014)PIC1791PFQ51PIC1791PFQ51 None   E11D, S17T, V32I, M50I, I72V, L101I, T112A, S119G, T122I, T125S, I182V, I203M, D256EB
 PIC1875PGK57PIC1875PGK57 None   E11D, V31I, L45Q, S57N, L101I, S119G, T122I, T124N, T125S, G163E, K173R, A205TB