<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation T125M
Rx II-naive
IncludeMixtures No
References 23
Patients 49
Isolates 49
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Miura (2008)BEC50BEC50EU517875None   S17N, N18D, I72V, T124A, T125M, K127R, G134S, I208M, D286NB
 BEC106BEC106EU517894None  A128TM50I, I72V, T124N, T125M, G193E, S230NB
Brumme (2009)INT_3576INT_3576FJ813027None  V54VIV31I, L101I, T124TA, T125M, V150A, K173RB
 INT_3662INT_3662FJ813113None   E11D, V32I, I72V, T124S, T125M, V126M, M154L, V201I, T206SB
 INT_3816INT_3816FJ813267None   E11D, S24N, V31I, L101I, K111A, T112A, S119P, T124N, T125M, S283GB
 INT_3906INT_3906FJ813357None   E11ED, I72V, T124S, T125M, V126M, M154L, V201IB
 INT_3926INT_3926FJ813377None   V32I, S39C, M50MI, L101I, T124Q, T125M, I135IV, V201I, K240R, S283SDGNB
 J8593J8593GQ371949None   E11D, S24G, D25E, S39C, L101LI, S119P, T122I, T125M, V201IB
 M1533M1533GQ372003None E138EK T124N, T125M, K156N, S195SC, T218SB
 O1538O1538GQ372053None   S17SN, L28I, L101I, T112TI, T124TADN, T125M, I135IV, K156KN, E157EK, D167DE, R262RKB
 T9524T9524GQ372194None   V31I, T125M, K156N, E157Q, V201I, I203M, K211R, I217VB
 W9532W9532GQ372243None   D6E, S17N, I60M, L101I, T124A, T125M, I135V, M154I, V165I, Q216H, K219Q, N222NI, D278NB
 X6532X6532GQ372261None   S17N, D55N, I72V, L101I, T124A, T125M, I135V, F181I, I220M, N222A, A265VB
Eshleman (2009)BrRJ96-011BrRJ96-011FJ480328None   V31I, K111T, S119T, T125M, T206S, I220IMB
Garrido (2009)280INT-280GU217127None   E11D, S24N, L101I, T125M, K156N, G193R, V201IB
 360INT-360GU217207None R263RK E11D, D25E, V31I, L45Q, T93N, L101I, T112I, S119P, T122I, T124A, T125MB
Low (2009)ahi4ahi4_98FJ786271None   V31I, I72V, L101I, I113V, T124N, T125M, L172I, K188R, L234I, A265VB
 ahi34ahi34_05FJ786301None   D6E, E10D, T124N, T125M, G163EB
 mdr1amdr1aFJ786380None  A128TS17N, I72V, T125M, G163E, I208L, K211Q, E212AB
 mdr1bmdr1bFJ786381None  A128TS17N, I72V, T125M, G163E, I208L, K211Q, E212A, I220LB
 mdr1cmdr1cFJ786382None  A128TS17N, I72V, T125M, G163E, I208L, K211Q, E212A, I220LB
 mdr1dmdr1dFJ786383None  A128TS17N, I72V, T125M, G163E, I208L, K211Q, E212AB
 mdr1emdr1eFJ786384None  A128TS17N, I72V, T125M, G163E, I208L, K211Q, E212AB
Avi (2010)R4R4GQ926741None  V151I, G163RE11D, A21T, I72V, T112I, I113V, T125M, T218S, L234VB
Rangel (2010)HIV190bHIV190bGU797504None  V151IP90PS, I113V, T124N, T125M, V201I, T206S, I208L, D256EB
Brenner (2011)96049604HQ207797None   V31I, I72V, T112A, T124N, T125M, M154L, S230N, D256E, S283GB
Rolland (2011)2667consensus_2667JF320145None   S17N, V31I, L45Q, L74I, L101I, T124A, T125M, G163E, V201I, Q221K, N222K, S255KB
Armenia (2012)PT_63PT_63_BLJN544098None   S24N, D25DE, L101I, T124Q, T125M, M154I, V165I, D232E, L234VB
Brockman (2012)AEHIV4AEHIV4JQ080088None   L101I, S119T, T124Q, T125M, G193E, S283G, D288NB
 AEHIV27AEHIV27JQ080111None   I72V, I113V, T124A, T125M, M154MI, V201IB
Jahanbakhsh (2012)THR46THR46INTAB716183None   D6E, S17N, L28I, V31I, S39C, I60V, I113IV, T124N, T125M, I203M, I220LB
Parczewski (2012)297_2297_2KC409154None   L101I, T112I, I113IV, T125M, E157Q, K160Q, G163V, V201VI, S230N, L234I, A265VB
Zeng (2012)CN1300CN1300JQ028315None   E11D, A21T, S57G, Q95R, L101I, T125M, I135V, I162V, D167E, V201I, L234I, S283G, Q285PB
Reigadas (2013)8181JX425549None   S17N, M50T, I72V, L101I, S119P, T122I, T124A, T125M, G163E, Q209P, C280R, S283GB
 9292JX425560None   V32IL, L101I, K111KR, T124N, T125M, K215N, N222K, S230N, A265VB
Martin (2014)CHR12CHR12KJ869735None   E11D, L28I, V37I, S39C, L101I, S119T, T124N, T125M, I135IV, K156N, V201I, I208L, S230NB
 ACU3ACU3KJ869612None   I72V, I113V, T124A, T125M, M154MI, V201IB
Hachiya (2015)95799579LC022172None  L68LVH12HY, A23V, L28I, S39N, I72IS, L101I, T112I, S119G, T122I, T124N, T125M, K215N, Q221S, N222K, D256E, V281VMB
Kinloch (2015)INT_131INT_131KT167690None  E138DL45V, T124S, T125M, G163GEB
 INT_218INT_218KT167777None  V151IE11ED, I72V, G82GR, E85EK, T125M, A265VB
 INT_62INT_62KT167621None   S17SN, T124N, T125M, K156N, S255RB
 INT_84INT_84KT167643None   S17N, A23T, M50MI, I72V, T125M, D278AB
 INT_235INT_235KT167794None   T125M, A265VB
Pessoa (2015)10BR_SP050SP050KJ849812None   I72V, I113V, T124Q, T125M, F181L, T206S, D279G, S283G, R284GB
Bradley-Stewart (2017)WoSSVC_INT69WoSSVC_INT69MF442508None   E11D, K14R, L28I, V31VI, V32I, Q53K, L101I, K111X, T112I, T124N, T125M, V201IB
Chen (2017)216511335216511335KY574920None   K7R, K34R, I72V, L74I, T125M, M154I, V201VI, S283GB
Hachiya (2017)C15-55551501LC161112LC161112None   L28I, T112V, I113V, T125M, K156N, V201I, K215N, D279G, S283G, D286NB
Meixenberger (2017)92-0564292-05642KM677447None  V151VIV32I, I72V, L101I, I113V, T124N, T125M, V201IB
 05-0049205-00492KM677613None   L101I, S119T, T124Q, T125M, G193EB