Integrase Inhibitors

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Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	T125M
Rx	II-naive
IncludeMixtures	No

References	11
Patients	28
Isolates	28

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	INIMajorDRMs	INIMinorDRMs	OtherMut	Subtype
Miura (2008)	BEC50	BEC50	EU517875	None			S17N, N18D, I72V, T124A, T125M, K127R, G134S, I208M, D286N	B
	BEC106	BEC106	EU517894	None		A128T	M50I, I72V, T124N, T125M, G193E, S230N	B
Brumme (2009)	INT_3576	INT_3576	FJ813027	None		V54VI	V31I, L101I, T124TA, T125M, V150A, K173R	B
	INT_3662	INT_3662	FJ813113	None			E11D, V32I, I72V, T124S, T125M, V126M, M154L, V201I, T206S	B
	INT_3816	INT_3816	FJ813267	None			E11D, S24N, V31I, L101I, K111A, T112A, S119P, T124N, T125M, S283G	B
	INT_3906	INT_3906	FJ813357	None			E11ED, I72V, T124S, T125M, V126M, M154L, V201I	B
	INT_3926	INT_3926	FJ813377	None			V32I, S39C, M50MI, L101I, T124Q, T125M, I135IV, V201I, K240R, S283SDGN	B
	J8593	J8593	GQ371949	None			E11D, S24G, D25E, S39C, L101LI, S119P, T122I, T125M, V201I	B
	M1533	M1533	GQ372003	None	E138EK		T124N, T125M, K156N, S195SC, T218S	B
	O1538	O1538	GQ372053	None			S17SN, L28I, L101I, T112TI, T124TADN, T125M, I135IV, K156KN, E157EK, D167DE, R262RK	B
	T9524	T9524	GQ372194	None			V31I, T125M, K156N, E157Q, V201I, I203M, K211R, I217V	B
Eshleman (2009)	BrRJ96-011	BrRJ96-011	FJ480328	None			V31I, K111T, S119T, T125M, T206S, I220IM	B
Garrido (2009)	280	INT-280	GU217127	None			E11D, S24N, L101I, T125M, K156N, G193R, V201I	B
	360	INT-360	GU217207	None		R263RK	E11D, D25E, V31I, L45Q, T93N, L101I, T112I, S119P, T122I, T124A, T125M	B
Low (2009)	ahi4	ahi4_98	FJ786271	None			V31I, I72V, L101I, I113V, T124N, T125M, L172I, K188R, L234I, A265V	B
	ahi34	ahi34_05	FJ786301	None			D6E, E10D, T124N, T125M, G163E	B
	mdr1a	mdr1a	FJ786380	None		A128T	S17N, I72V, T125M, G163E, I208L, K211Q, E212A	B
	mdr1b	mdr1b	FJ786381	None		A128T	S17N, I72V, T125M, G163E, I208L, K211Q, E212A, I220L	B
	mdr1c	mdr1c	FJ786382	None		A128T	S17N, I72V, T125M, G163E, I208L, K211Q, E212A, I220L	B
	mdr1d	mdr1d	FJ786383	None		A128T	S17N, I72V, T125M, G163E, I208L, K211Q, E212A	B
	mdr1e	mdr1e	FJ786384	None		A128T	S17N, I72V, T125M, G163E, I208L, K211Q, E212A	B
Avi (2010)	R4	R4	GQ926741	None		V151I, G163R	E11D, A21T, I72V, T112I, I113V, T125M, T218S, L234V	B
Rangel (2010)	HIV190b	HIV190b	GU797504	None		V151I	P90PS, I113V, T124N, T125M, V201I, T206S, I208L, D256E	B
Brenner (2011)	9604	9604	HQ207797	None			V31I, I72V, T112A, T124N, T125M, M154L, S230N, D256E, S283G	B
Rolland (2011)	2667	consensus_2667	JF320145	None			S17N, V31I, L45Q, L74I, L101I, T124A, T125M, G163E, V201I, Q221K, N222K, S255K	B
Brockman (2012)	AEHIV4	AEHIV4	JQ080088	None			L101I, S119T, T124Q, T125M, G193E, S283G, D288N	B
	AEHIV27	AEHIV27	JQ080111	None			I72V, I113V, T124A, T125M, M154MI, V201I	B
Parczewski (2012)	297_2	297_2	KC409154	None			L101I, T112I, I113IV, T125M, E157Q, K160Q, G163V, V201VI, S230N, L234I, A265V	B

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