<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype B
Gene IN
Mutation T125A
Rx >=1 INI
IncludeMixtures No
References 18
Patients 69
Isolates 117
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Charpentier (2008)Pt1Pt1-W4 RAL4Q148R E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
  Pt1-W8 RAL8Q148R E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, V259I, D278EB
  Pt1-W11 RAL11G140GS, Q148QH, N155NH E11D, A21T, A23AV, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
  Pt1-W22 RAL22G140GS, Q148QH E11D, A21T, A23AV, D25E, L101LF, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256DE, D278EB
  Pt1-W39 RAL39G140GS, Q148QH E11D, A21T, A23AV, D25E, L101LF, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256DE, D278EB
Malet (2008)1bH-SH1-W8FJ538990RAL8Q148R, N155H E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
  H-SH1-W16FJ538991RAL15G140S, Q148H E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
 1cSH2-W10FJ538988RAL11G140S, Q148H S17N, L28I, S39C, S119P, T122I, T124A, T125AB
 H1H1-W12FJ538974RAL13N155H L2W, K7R, R20K, V31I, L101I, T112V, T124A, T125A, F181L, V201I, K219N, N222KB
 H6H6-W20FJ538984RAL20N155HT97A, V151IE11D, V31I, L101I, K111T, I113V, S119T, T124N, T125A, S195C, A196P, A205T, T218S, D232NB
 HSH2H-SH2-W12FJ538993RAL16N155H S17N, R20K, L28I, S39C, T124A, T125A, V201I, I208LB
  H-SH2-W22FJ538994RAL22G140S, Q148HG163RS17N, R20K, L28I, S39C, G70R, T124A, T125A, V201I, I208LB
Baldanti (2009)PV4PV4GU350730RAL4  E10D, L101I, S119P, T122I, T125A, V165I, V201I, I208L, K215N, D256EB
Canducci (2009)pt1pt1w4EU908743RAL4  S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216HB
  pt1W12EU908744RAL13  S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216HB
  pt1w24EU908745RAL26Y143R S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216HB
  pt1w48EU908746RAL39Y143R S17SN, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216HB
 pt3pt3w4EU908756RAL4 V54IV31I, I113V, T124A, T125A, V201I, K215NB
  pt3w12EU908757RAL13 V54IV31I, I113V, T124A, T125A, V201I, K215NB
  pt3w24EU908758RAL26G140S, Q148HV54IV31I, I113V, T124A, T125A, V201I, K215NB
 pt4pt4W4EU908760RAL4 R263KD3Q, G70E, L101I, S119R, T124N, T125A, M154L, V165I, K211R, Q252X, D256E, R262EB
  pt4W12EU908761RAL13  D3Q, G70E, L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256EB
  pt4W24EU908762RAL26Y143CT97AD3Q, L101I, S119R, T124N, T125A, M154L, V165I, D256EB
  pt4w32EU908763RAL35Y143CT97AD3Q, L101I, S119R, T124N, T125A, M154L, V165I, K211KR, D256EB
  pt4w36EU908764RAL39Y143CL74M, T97AD3Q, L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256EB
 pt7pt7w4EU908766RAL4  S24A, L101I, T112TI, T125A, I135V, F181L, T206S, D229E, S230N, D256EB
  pt7w8EU908767RAL8  S24A, L101I, T125A, I135V, F181L, T206S, D229E, S230N, D256DEB
  pt7w12EU908768RAL13  S24A, L101I, T125A, I135V, F181L, T206S, D229E, S230N, D256EB
  pt7w20EU908769RAL21  S24A, T125A, I135V, F181L, T206S, D229E, S230N, D256EB
  pt7w24EU908770RAL26  S24A, L101LI, T125A, I135V, F181L, T206S, D229E, S230N, D256EB
 pt5pt5w24EU908775RAL26N155NHV151IK14R, M22L, V32I, V37I, S39C, L101I, T125A, G163Q, E170Q, V201I, D253EB
Delelis (2009)Pt1Pt1 RAL48Y143R V32I, S39C, K111R, T124N, T125A, G193E, N254KB
 Pt3Pt3 RAL16Y143R I113V, T124NS, T125A, T206S, I220L, Y227FB
Garrido (2009)Pt01Pt01 RAL G140A, Q148R K14R, S24G, D25E, L45I, I113V, T124N, T125A, E157Q, K160S, V165VI, I220L, Y227F, L234V, D256EB
 Pt03Pt03 RAL Y143RT97AH12HN, V31I, K111T, S119T, T125A, V126L, I135V, P142A, I203M, I208L, D256EB
 Pt18Pt18 RAL   E10A, E11D, S24N, I113V, S119SG, T122I, T124N, T125A, I220LB
Sichtig (2009)Pt075163FJ183699RAL62N155HQ146QKE11D, K14R, A21T, A23V, V88I, I113V, S119P, T124N, T125A, Q177R, T206SB
 Pt013-KoelnFJ183691RAL31G140GA, Q148QR S119G, T122I, T125A, V201I, K215NB
  4786FJ183692RAL47Y143RL74M, T97AE11D, R20K, V31I, H51HR, S119G, T122I, T125A, V201I, K215NB
 Pt025068FJ183700RAL35G140S, Q148HG163KS17N, R20K, L28I, S39C, L45V, I113V, T124N, T125A, V201I, V259IB
  5864FJ183701RAL79G140S, Q148HG163EKQS17N, R20K, L28I, S39C, L45V, I113L, T124N, T125A, V201IB
 Pt044833FJ183697RAL41N155HV151VI, G163GRS17N, V31I, T112V, T124N, T125A, V126L, S230N, D256EB
  4951FJ183698RAL50N155HV151I, G163RS17N, V31I, T112V, T124N, T125A, V126L, S230N, D256EB
Wittkop (2009)11_M6GU358379RAL25G140S, Q148H E10D, R20K, V32I, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222KB
  1_M9GU358380RAL39E138EA, G140S, Q148H E10D, R20K, V32I, L45LI, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K, V259VIB
  1_M12GU358381RAL52E138EA, G140S, Q148H E10D, R20K, V32VI, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K, V259VIB
 77_M3GU358385RAL12N155H S17N, I72V, L101I, S119G, T122I, T125A, A169S, T218S, I220L, Y227FB
  7_M6GU358386RAL25Y143YCHRT97TA, G163GRS17N, I72V, L101I, S119G, T122I, T125A, A169S, T218TS, I220L, Y227FB
  7_M9GU358387RAL39Y143YCHRT97TA, G163GRS17N, I72V, L101I, G106GA, S119G, T122I, T125A, A169FS, F185FL, S195SN, A196AT, T218TS, I220L, Y227FB
 66_M3GU358398RAL12Y143CL74LM, Q95QK, V151VI, S230RK7KR, S17N, V31I, T97TP, K111T, I113V, T124Q, T125A, A169AV, G189GV, I203MB
  6_M6GU358399RAL26Y143YCL74LMK7KR, S17N, V31I, K111T, I113V, T124Q, T125A, G189R, I203M, D279DA, S283SGB
Hatano (2010)4Virus15GU121691RAL Y143RT97AK7R, S17N, V31I, L101I, T112A, T125A, M154I, V201IB
  Virus16GU121692RAL Y143RT97A, G163GRK7R, S17N, V31I, L101I, T112A, S119T, T125A, M154I, V201VIB
 18Virus19GU121695EVG   K7R, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus91GU121767EVG   K7R, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203IM, I208L, L234IB
  Virus94GU121770EVG E92Q K7KR, D41DN, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234IB
  Virus95GU121771EVG E92Q, Q148QRL74LMK7KR, D41DN, I72IV, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234IB
  Virus97GU121773EVG E92QL68LV, L74LMK7KR, D41DN, I72IV, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234IB
 17Virus99GU121775EVG E138K, S147G, Q148R K7KR, I72V, V79VI, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus100GU121776EVG E138K, S147G, Q148RV54VIK7KR, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus103GU121779EVG E138K, S147G, Q148RV54VIK7KR, E35EQ, I72IV, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
  Virus20GU121696EVG E138K, S147G, Q148RV54IK7KR, E35EK, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234IB
 12Virus101GU121777RAL Y143YCT97A, S230RG4GR, R20K, T112V, I113V, T125A, H171Q, Y194YH, I200M, I203MB
  Virus122GU121798RAL Y143YCT97TA, S230SRR20K, T112V, I113V, T125A, H171Q, I200M, I203IMB
  Virus139GU121815RAL Y143YCL74LM, T97TA, S230SRR20K, T112V, I113V, S119ST, T125A, H171Q, I200M, I203IM, T218TSB
 11Virus104GU121780RAL G140GS, N155HA128AT, V151VIE10DG, E11D, V31I, S119P, T122I, T125A, V126M, G163E, S195C, L234V, D279DNB
Blanco (2011)CA4825CA128619 RAL21N155HG163KE11D, S24N, V31I, L101I, I113V, S119P, T122I, T124N, T125A, V201I, K211KRB
 CA5016CA128616 RAL29  S119G, T122I, T125A, M154L, I203M, L234I, D256EB
 CA25689CA128612 RAL27  E11D, A21T, V77A, S119P, T122I, T125A, D232E, L234HB
 ACM_09BLACM_09BL RAL N155H E10D, S119G, T122I, T124N, T125A, M154I, K211RB
Brenner (2011)INT3INT3_1HQ207824RAL   E11D, S24N, V31I, L45V, I72V, T112V, S119P, T122I, T125A, I203IM, K215NB
 1112211122HQ423448RAL   M50I, E96D, T112V, H114HP, S119R, T125A, I141IVB
Canducci (2011)Pt2Pt2W24JN163881RAL26Y143CT97AL101I, S119R, T124N, T125A, M154L, V165I, D256E, G277CB
  Pt2W36JN163882RAL35 L74M, T97A, Y143GL101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G277CB
  Pt2W37JN163883RAL36 L74M, T97A, Y143GI36V, L101I, S119R, T124N, T125A, M154L, V165I, D256EB
  Pt2W56JN163884RAL55Y143RT97AL101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G277RB
  Pt2W64JN163885RAL64E138A, Y143CL74M, T97AL101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G272E, G277RB
 Pt3Pt3W24JN163887RAL26Y143R S17N, S24N, I113V, S119T, T124A, T125A, V165I, V201I, T206S, E212K, Q216HB
 Pt4Pt4W24JN163889RAL26G140S, Q148HV54IV31I, I113V, T124A, T125A, V201I, K215N, G277CB
 Pt10Pt10w20JN163905RAL21Q148R S24N, L74I, L101I, T125A, V201I, Q216HB
  Pt10w28JN163906RAL30G140S, Q148H S24N, L101I, T125A, V201I, Q216HB
  Pt10w32JN163907RAL35G140S, Q148H S24N, D41N, L74I, A91T, L101I, T125A, V201I, Q216H, N254SB
Armenia (2012)PT_141PT_141_MO_6JN544113RAL N155HV151I, G163GRD6T, K7E, E11D, K14R, V31I, M50I, I72IV, I113V, S119SR, T125A, V201I, D256E, V281VMB
Fransen (2012)pt3pt3 RAL G140GS, Q148QHR, N155NHV151IE11D, A21T, A23AV, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278EB
Garrido (2012)BAA295871BAA295871JQ716889RAL52  E11D, F26Y, V31I, I60V, I72IV, T112I, T124N, T125A, V126M, G193R, I203M, Q216H, K219QB
 BAA295891BAA295891JQ716892RAL52G140A, Q148R K14R, S24G, D25E, L45I, I113V, T124N, T125A, E157Q, K160S, V165VI, I220L, Y227F, L234V, D256EB
 BAA295905BAA295905JQ716898RAL52G140GS, Q148QH E10D, V31I, I72V, L101I, S119G, T122I, T125A, K156N, V201I, T206S, Q216H, Q221R, D256EB
 BAA295915BAA295915JQ716902RAL52  D6E, L28I, V37I, S39C, I84IM, L101I, T124A, T125A, I135VB
Parczewski (2012)307307_18KC409156RAL196N155H E10D, L101I, T112I, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278GB
  307_xKC409158RAL201N155H E10D, L101I, T112I, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278GB
Souza Cavalcanti (2012)BRSPBR10SP296JQ797733RAL130E138K, G140C, Q148RV54IE11D, V31I, V32I, V37I, D41N, V79I, L101I, T125A, K136Q, V201I, T206S, L234V, D270EB
de Souza Cavalcanti (2014)BRSP526BRSP526 RAL G140S, Q148H K7Q, R20RK, L63V, S119P, T122I, T124A, T125A, V165VI, K219N, N222K, S283SGB
 BRSP54BRSP54 RAL   S17N, I72V, I84M, N117T, T124A, T125A, M154I, V201I, Q221NB
 BRSP287BRSP287 RAL G140S, Q148HT97AK14KR, R20K, G70E, L101I, T112V, S119R, T124S, T125A, V201I, D232NB
 BRSP461BRSP461 RAL G140A, Q148R K14R, S17N, V31I, V32VG, S39R, V79I, L101I, S119G, T122I, T125A, P142SB
 BRSP222BRSP222 RAL Y143RL74M, T97A, E138DE10D, V31I, M50I, L101I, T112V, S119P, T122I, T124N, T125A, I135V, E157Q, I203M, I208L, T218S, I220L, D253VB
 BRSP17BRSP17 RAL G140A, Q148R E10D, V31I, M50I, V79I, L101I, K111T, S119T, T124Q, T125A, I135V, I203M, I208L, L234LV, V259VIB
 BRSP10BRSP10 RAL  T97A, V151IS17N, S24A, G59E, I60L, I72V, L101I, T112V, T124N, T125AB
 BRSP367BRSP367 RAL G140S, Q148H D6E, S17N, R20K, M22L, L28M, E35Q, S39N, L101I, T125A, K136N, I200L, V201IB
 BRSP148BRSP148 RAL G140S, Q148H S17N, A21S, D25E, V31I, L63LI, L74I, L101I, K111R, I113L, S119P, T122I, T125A, G163E, H171Q, T218S, S283GB
 BRSP263BRSP263 RAL   D6N, K7E, V31I, L74I, T112I, T125A, F181L, T206S, L234I, D288NB
 BRSP385BRSP385 RAL N155HV151IS24G, S119P, T122I, T124A, T125A, V201I, A205S, S255NB
 BRSP208BRSP208 RAL   E11D, V31I, K42KR, L101I, K111T, I113V, S119P, T125A, I135V, F181L, V201I, I204IV, T206S, E212A, T218S, K219T, N222K, N254NK, C280SB
 BRSP268BRSP268 RAL N155HV151IS17N, L28I, T112I, S119G, T122I, T124N, T125A, E157Q, K160Q, V201IB
 BRSP594BRSP594 RAL G140S, Q148H D6N, K7D, V32I, L45V, L101I, T125A, I135VB
 BRSP145BRSP145 RAL N155HV151VIS17N, S24D, L28I, S39C, T124N, T125A, V126L, T218S, D278NB
 BRSP591BRSP591 RAL  V151IS17N, L101I, S119P, T124N, T125A, I135V, S195C, D256EB
 BRSP296BRSP296 RAL E138K, G140C, Q148RV54IE11D, V31I, V32I, V37I, D41N, V79I, L101I, T125A, K136Q, V201I, T206S, L234V, D270EB
 BRSP195BRSP195 RAL   E10D, D41N, M50T, L101I, T122I, T124A, T125A, V201I, I208L, S283GB
 BRSP239BRSP239 RAL E138K, S147G, Q148RV151I, G163RK14R, L74I, V75M, V79I, S119P, T122I, T124A, T125A, K156N, V201I, T218I, L234V, D256E, S283G, R284GB
 BRSP322BRSP322 RAL   D6T, K7Q, E10D, R20K, G59GE, I72V, S119P, T122V, T125A, I203M, T206S, I208IL, L234LH, D278E, S283GB
 BRSP458BRSP458 RAL E138AT, G140S, Q148H D6NS, K7E, S17N, V31I, L101I, T124TN, T125A, K156N, K160KR, I203M, Q221K, N222K, D256E, R284GB
 BRSP39BRSP39 RAL G140S, Q148H A23V, T125A, M154I, A169T, R187K, K188R, V201IB
 BRSP521BRSP521 RAL G140S, Q148H V31I, L63I, G70E, L101I, S119R, T122I, T125A, K160R, V201I, A205S, L234IB
 BRSP551BRSP551 RAL   S17N, D41E, I72V, L101I, S119G, T122I, T125A, V201I, A205AV, T218L, K219Q, L234I, D256EB
 BRSP14BRSP14 RAL G140S, Q148H Y15I, H16N, I72V, V88I, L101I, T122I, T125A, I135V, F181L, V201I, L234V, K273Q, D278NB
 BRSP473BRSP473 RAL   V31I, V88I, L101I, T125A, K173KR, F181L, A265VB