Integrase Inhibitors

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Integrase Inhibitors

Subtype	B
Gene	IN
Mutation	T125A
Rx	>=1 INI
IncludeMixtures	No

References	15
Patients	39
Isolates	80

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	Wks	INIMajorDRMs	INIMinorDRMs	OtherMut	Subtype
Charpentier (2008)	Pt1	Pt1-W4		RAL	4	Q148R		E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
		Pt1-W8		RAL	8	Q148R		E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, V259I, D278E	B
		Pt1-W11		RAL	11	G140GS, Q148QH, N155NH		E11D, A21T, A23AV, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
		Pt1-W22		RAL	22	G140GS, Q148QH		E11D, A21T, A23AV, D25E, L101LF, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256DE, D278E	B
		Pt1-W39		RAL	39	G140GS, Q148QH		E11D, A21T, A23AV, D25E, L101LF, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D256DE, D278E	B
Malet (2008)	1b	H-SH1-W8	FJ538990	RAL	8	Q148R, N155H		E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
		H-SH1-W16	FJ538991	RAL	15	G140S, Q148H		E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
	1c	SH2-W10	FJ538988	RAL	11	G140S, Q148H		S17N, L28I, S39C, S119P, T122I, T124A, T125A	B
	H1	H1-W12	FJ538974	RAL	13	N155H		L2W, K7R, R20K, V31I, L101I, T112V, T124A, T125A, F181L, V201I, K219N, N222K	B
	H6	H6-W20	FJ538984	RAL	20	N155H	T97A, V151I	E11D, V31I, L101I, K111T, I113V, S119T, T124N, T125A, S195C, A196P, A205T, T218S, D232N	B
	HSH2	H-SH2-W12	FJ538993	RAL	16	N155H		S17N, R20K, L28I, S39C, T124A, T125A, V201I, I208L	B
		H-SH2-W22	FJ538994	RAL	22	G140S, Q148H	G163R	S17N, R20K, L28I, S39C, G70R, T124A, T125A, V201I, I208L	B
Baldanti (2009)	PV4	PV4	GU350730	RAL	4			E10D, L101I, S119P, T122I, T125A, V165I, V201I, I208L, K215N, D256E	B
Canducci (2009)	pt1	pt1w4	EU908743	RAL	4			S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H	B
		pt1W12	EU908744	RAL	13			S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H	B
		pt1w24	EU908745	RAL	26	Y143R		S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H	B
		pt1w48	EU908746	RAL	39	Y143R		S17SN, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H	B
	pt3	pt3w4	EU908756	RAL	4		V54I	V31I, I113V, T124A, T125A, V201I, K215N	B
		pt3w12	EU908757	RAL	13		V54I	V31I, I113V, T124A, T125A, V201I, K215N	B
		pt3w24	EU908758	RAL	26	G140S, Q148H	V54I	V31I, I113V, T124A, T125A, V201I, K215N	B
	pt4	pt4W4	EU908760	RAL	4		R263K	D3Q, G70E, L101I, S119R, T124N, T125A, M154L, V165I, K211R, Q252X, D256E, R262E	B
		pt4W12	EU908761	RAL	13			D3Q, G70E, L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E	B
		pt4W24	EU908762	RAL	26	Y143C	T97A	D3Q, L101I, S119R, T124N, T125A, M154L, V165I, D256E	B
		pt4w32	EU908763	RAL	35	Y143C	T97A	D3Q, L101I, S119R, T124N, T125A, M154L, V165I, K211KR, D256E	B
		pt4w36	EU908764	RAL	39	Y143C	L74M, T97A	D3Q, L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E	B
	pt7	pt7w4	EU908766	RAL	4			S24A, L101I, T112TI, T125A, I135V, F181L, T206S, D229E, S230N, D256E	B
		pt7w8	EU908767	RAL	8			S24A, L101I, T125A, I135V, F181L, T206S, D229E, S230N, D256DE	B
		pt7w12	EU908768	RAL	13			S24A, L101I, T125A, I135V, F181L, T206S, D229E, S230N, D256E	B
		pt7w20	EU908769	RAL	21			S24A, T125A, I135V, F181L, T206S, D229E, S230N, D256E	B
		pt7w24	EU908770	RAL	26			S24A, L101LI, T125A, I135V, F181L, T206S, D229E, S230N, D256E	B
	pt5	pt5w24	EU908775	RAL	26	N155NH	V151I	K14R, M22L, V32I, V37I, S39C, L101I, T125A, G163Q, E170Q, V201I, D253E	B
Delelis (2009)	Pt1	Pt1		RAL	48	Y143R		V32I, S39C, K111R, T124N, T125A, G193E, N254K	B
	Pt3	Pt3		RAL	16	Y143R		I113V, T124NS, T125A, T206S, I220L, Y227F	B
Garrido (2009)	Pt01	Pt01		RAL		G140A, Q148R		K14R, S24G, D25E, L45I, I113V, T124N, T125A, E157Q, K160S, V165VI, I220L, Y227F, L234V, D256E	B
	Pt03	Pt03		RAL		Y143R	T97A	H12HN, V31I, K111T, S119T, T125A, V126L, I135V, P142A, I203M, I208L, D256E	B
	Pt18	Pt18		RAL				E10A, E11D, S24N, I113V, S119SG, T122I, T124N, T125A, I220L	B
Sichtig (2009)	Pt07	5163	FJ183699	RAL	62	N155H	Q146QK	E11D, K14R, A21T, A23V, V88I, I113V, S119P, T124N, T125A, Q177R, T206S	B
	Pt01	3-Koeln	FJ183691	RAL	31	G140GA, Q148QR		S119G, T122I, T125A, V201I, K215N	B
		4786	FJ183692	RAL	47	Y143R	L74M, T97A	E11D, R20K, V31I, H51HR, S119G, T122I, T125A, V201I, K215N	B
	Pt02	5068	FJ183700	RAL	35	G140S, Q148H	G163K	S17N, R20K, L28I, S39C, L45V, I113V, T124N, T125A, V201I, V259I	B
		5864	FJ183701	RAL	79	G140S, Q148H	G163EKQ	S17N, R20K, L28I, S39C, L45V, I113L, T124N, T125A, V201I	B
	Pt04	4833	FJ183697	RAL	41	N155H	V151VI, G163GR	S17N, V31I, T112V, T124N, T125A, V126L, S230N, D256E	B
		4951	FJ183698	RAL	50	N155H	V151I, G163R	S17N, V31I, T112V, T124N, T125A, V126L, S230N, D256E	B
Wittkop (2009)	1	1_M6	GU358379	RAL	25	G140S, Q148H		E10D, R20K, V32I, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K	B
		1_M9	GU358380	RAL	39	E138EA, G140S, Q148H		E10D, R20K, V32I, L45LI, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K, V259VI	B
		1_M12	GU358381	RAL	52	E138EA, G140S, Q148H		E10D, R20K, V32VI, M50I, I72V, L101I, S119G, T122I, T125A, F181L, K211R, Q221S, N222K, V259VI	B
	7	7_M3	GU358385	RAL	12	N155H		S17N, I72V, L101I, S119G, T122I, T125A, A169S, T218S, I220L, Y227F	B
		7_M6	GU358386	RAL	25	Y143YCHR	T97TA, G163GR	S17N, I72V, L101I, S119G, T122I, T125A, A169S, T218TS, I220L, Y227F	B
		7_M9	GU358387	RAL	39	Y143YCHR	T97TA, G163GR	S17N, I72V, L101I, G106GA, S119G, T122I, T125A, A169FS, F185FL, S195SN, A196AT, T218TS, I220L, Y227F	B
	6	6_M3	GU358398	RAL	12	Y143C	L74LM, Q95QK, V151VI, S230R	K7KR, S17N, V31I, T97TP, K111T, I113V, T124Q, T125A, A169AV, G189GV, I203M	B
		6_M6	GU358399	RAL	26	Y143YC	L74LM	K7KR, S17N, V31I, K111T, I113V, T124Q, T125A, G189R, I203M, D279DA, S283SG	B
Hatano (2010)	4	Virus15	GU121691	RAL		Y143R	T97A	K7R, S17N, V31I, L101I, T112A, T125A, M154I, V201I	B
		Virus16	GU121692	RAL		Y143R	T97A, G163GR	K7R, S17N, V31I, L101I, T112A, S119T, T125A, M154I, V201VI	B
	18	Virus19	GU121695	EVG				K7R, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
		Virus91	GU121767	EVG				K7R, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203IM, I208L, L234I	B
		Virus94	GU121770	EVG		E92Q		K7KR, D41DN, I72V, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234I	B
		Virus95	GU121771	EVG		E92Q, Q148QR	L74LM	K7KR, D41DN, I72IV, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234I	B
		Virus97	GU121773	EVG		E92Q	L68LV, L74LM	K7KR, D41DN, I72IV, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, E212EA, L234I	B
	17	Virus99	GU121775	EVG		E138K, S147G, Q148R		K7KR, I72V, V79VI, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
		Virus100	GU121776	EVG		E138K, S147G, Q148R	V54VI	K7KR, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
		Virus103	GU121779	EVG		E138K, S147G, Q148R	V54VI	K7KR, E35EQ, I72IV, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
		Virus20	GU121696	EVG		E138K, S147G, Q148R	V54I	K7KR, E35EK, I72V, V79I, V88I, K111Q, I113V, T124A, T125A, G163E, I203M, I208L, L234I	B
	12	Virus101	GU121777	RAL		Y143YC	T97A, S230R	G4GR, R20K, T112V, I113V, T125A, H171Q, Y194YH, I200M, I203M	B
		Virus122	GU121798	RAL		Y143YC	T97TA, S230SR	R20K, T112V, I113V, T125A, H171Q, I200M, I203IM	B
		Virus139	GU121815	RAL		Y143YC	L74LM, T97TA, S230SR	R20K, T112V, I113V, S119ST, T125A, H171Q, I200M, I203IM, T218TS	B
	11	Virus104	GU121780	RAL		G140GS, N155H	A128AT, V151VI	E10DG, E11D, V31I, S119P, T122I, T125A, V126M, G163E, S195C, L234V, D279DN	B
Blanco (2011)	CA4825	CA128619		RAL	21	N155H	G163K	E11D, S24N, V31I, L101I, I113V, S119P, T122I, T124N, T125A, V201I, K211KR	B
	CA5016	CA128616		RAL	29			S119G, T122I, T125A, M154L, I203M, L234I, D256E	B
	CA25689	CA128612		RAL	27			E11D, A21T, V77A, S119P, T122I, T125A, D232E, L234H	B
	ACM_09BL	ACM_09BL		RAL		N155H		E10D, S119G, T122I, T124N, T125A, M154I, K211R	B
Brenner (2011)	INT3	INT3_1	HQ207824	RAL				E11D, S24N, V31I, L45V, I72V, T112V, S119P, T122I, T125A, I203IM, K215N	B
	11122	11122	HQ423448	RAL				M50I, E96D, T112V, H114HP, S119R, T125A, I141IV	B
Fransen (2012)	pt3	pt3		RAL		G140GS, Q148QHR, N155NH	V151I	E11D, A21T, A23AV, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E	B
Garrido (2012)	BAA295871	BAA295871	JQ716889	RAL	52			E11D, F26Y, V31I, I60V, I72IV, T112I, T124N, T125A, V126M, G193R, I203M, Q216H, K219Q	B
	BAA295891	BAA295891	JQ716892	RAL	52	G140A, Q148R		K14R, S24G, D25E, L45I, I113V, T124N, T125A, E157Q, K160S, V165VI, I220L, Y227F, L234V, D256E	B
	BAA295905	BAA295905	JQ716898	RAL	52	G140GS, Q148QH		E10D, V31I, I72V, L101I, S119G, T122I, T125A, K156N, V201I, T206S, Q216H, Q221R, D256E	B
	BAA295915	BAA295915	JQ716902	RAL	52			D6E, L28I, V37I, S39C, I84IM, L101I, T124A, T125A, I135V	B
Parczewski (2012)	307	307_18	KC409156	RAL	196	N155H		E10D, L101I, T112I, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278G	B
		307_x	KC409158	RAL	201	N155H		E10D, L101I, T112I, T124N, T125A, E157Q, K160Q, K219T, I220L, S230N, L234I, D253E, D256E, D278G	B
Souza Cavalcanti (2012)	BRSP	BR10SP296	JQ797733	RAL	130	E138K, G140C, Q148R	V54I	E11D, V31I, V32I, V37I, D41N, V79I, L101I, T125A, K136Q, V201I, T206S, L234V, D270E	B

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