Integrase Inhibitors

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Integrase Inhibitors

Subtype	A
Gene	IN
Mutation	L74I
Rx	II-naive
IncludeMixtures	No

References	21
Patients	68
Isolates	69

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	INIs	INIMinorDRMs	OtherMut	Subtype
Alizon (1986)	MALCG	MAL MALCG	X04415	None		V31I, L74I, L101I, T112V, I113V, T124A, T125A, G134N, D167E, V201I, I203M, S230N, L234I, S283G, R284G	A
Dowling (2002)	KSM4024	KSM4024	AF457077	None	T97A	K14R, A21T, V31I, D41N, L74I, T112V, I113V, T124A, T125A, V126F, G134N, K136Q, E157Q, K160Q, D167E, V201I, Q216H, Y227F, L234V, S283G	A
Masharsky (2003)	A0116	98UA0116	AF413987	None		D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N	A
Meloni (2004)	DDI579	DDI579	AY521629	None	T97A	K14R, A21T, V31I, I72V, L74I, T112V, T124A, T125A, V126M, G134N, D167E, V201I, L234I, V260I, S283G	A
	DDJ360	DDJ360	AY521630	None		K14R, A21T, V31I, I72V, L74I, T112V, T124A, T125A, V126M, G134D, D167E, V201I, L234I, V260I, S283G	A
	DDJ369	DDJ369	AY521631	None		K14R, A21T, V31I, M50K, I72V, L74I, T112V, T124A, T125A, G134N, K136Q, D167E, V201I, K211Q, T218I, L234I, S283G	A
Adojaan (2005)	EST2002_394	2002_394	DQ167216	None		D3E, R20K, V31I, I72V, L74I, T112V, I113V, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, D232N	A
Carr (2005)	02UZ0663	02UZ0663	AY829210	None		D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N	A
Njai (2006)	MP1411	99CM.1411	AM279396	None	T97A	V31I, L63M, I72V, L74I, T112V, I113L, T124N, T125A, V126M, G134N, K136Q, L158LF, D167E, V201I, I203M, T218S, L234I	A
Saad (2006)	01UADN121	01UADN121	DQ823358	None		V32I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N	A
	01UADN139	01UADN139	DQ823357	None		D3E, R20K, V31I, I72V, L74I, T112V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, L234I, S255N, S283G	A
	01UAKV254	01UAKV254	DQ823361	None		D3E, R20K, V31I, I72V, L74I, L101LV, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N	A
	01UAPol293	01UAPol293	DQ823359	None		D3E, E11D, R20K, A21T, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, K211R, T218I, L234I, P238S, S255N	A
	01UAPol294	01UAPol294	DQ823356	None		D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N	A
	01UAPol303	01UAPol303	DQ823360	None		D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, W243X, S255N	A
	01UAOD10	01UAOD10	DQ823365	None		D3E, K14R, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, T218I, L234I, S255N	A
	01UAOD35	01UAOD35	DQ823366	None		D3E, K7Q, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, L234I, S255N	A
	01UAOD89	01UAOD89	DQ823367	None		D3E, R20K, L28I, L45Q, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, L234I, S255N	A
Badreddine (2007)	J11469	SB_J11469	DQ375282	None		E11D, K14R, A21AT, A23V, V31I, V32I, S39N, D41N, M50I, I72V, L74I, L101I, T112V, T125A, G134D, K136Q, D167E, V201I, K211KR, Q216H, N222H, L234I, D279G, S283G	A
Eyzaguirre (2007)	KZYUZ300413	02Y300413	EF589040	None		D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, G163E, D167E, V201I, T218I, L234I, S255N	A
	KZYUZ300425	02Y300425	EF589041	None		D3E, D6N, R20K, V31I, E35K, M50T, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N	A
	KZKAR300435	02K300435	EF589042	None		D3E, R20K, V31I, H51P, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N	A
	KZPAV300480	02P300480	EF589043	None		D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, K160R, D167E, V201I, T218I, L234I, S255N	A
	KZPAV300497	02P300497	EF589039	None	V54I	D3E, S17N, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N	A
	KZPAV300502	02P300502	EF589044	None		D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N	A
Brennan (2008)	124-33	124-33	EU618078	None		K14R, A21T, S39C, L63I, I72V, L74I, T112V, I113V, S119ST, T124A, T125A, V126M, G134N, I135V, D167E, V201I, K211R, Q216H, L234I, S283G	A
	193-6	193-6	EU618116	None		E11D, E13ED, K14KR, A21T, V31I, L63I, I72V, L74I, T112V, T124A, T125A, V126M, G134DN, I135V, D167E, V201I, Q216H, L234I, A265AV, S283G	A
	239-40	239-40	EU618123	None		E11D, K14R, A21T, M22MI, A23V, V31I, V32I, D41N, M50I, I72V, L74I, T112V, T124A, T125A, G134D, K136Q, D167E, V201I, L234I, S283G, D288N	A
	393-17	393-17	EU618170	None		V31I, M50I, L63I, I72V, L74I, F100Y, T112I, T124A, T125A, K136Q, D167E, V201I, L234I, S255N	A
	476-16	476-16	EU618204	None		K14R, A21T, V31I, I72V, L74I, T112I, T124G, T125A, G134N, K136T, D167E, V201I, L234I, S283G	A
	4832-9	4832-9	EU618207	None		E11D, V31I, V32I, L45I, I72IV, L74I, I89IV, T112V, T124TA, T125A, V126M, G134D, G163E, G193GE, V201I, L234I, N254K	A
	ABB08-96	ABB08-96	EU618497	None		K14R, A21T, V31I, L63V, I72V, L74I, T112V, S119G, T122I, T124A, T125A, K136Q, D167E, Q216H, L234I, A265V, S283G	A
	ABB191-98	ABB191-98	EU618617	None		K14R, A21T, A23V, D41N, L63I, I72V, L74I, T112V, T124A, T125A, V126M, G134D, I135V, D167E, V201I, Q216H, L234I, S255G, R269K, S283G	A
Brumme (2009)	INT_3927	INT_3927	FJ813378	None		K14R, S17C, I72V, L74I, T112IV, T124A, T125A, G134N, K136Q, D167E, V201I, L234I, S283G	A
Eshleman (2009)	ABB08-96	ABB08-96	FJ480267	None		K14R, A21T, V31I, L63V, I72V, L74I, T112V, S119G, T122I, T124A, T125A, K136Q, D167E, Q216H, L234I, A265V, S283G	A
	ABB213	ABB213	FJ480319	None		E11D, K14R, A21T, V31I, M50MV, I72V, L74I, T112V, T124A, T125A, V126M, G134N, K136Q, D167E, V201I, I208M, L234I, S283G	A
Garrido (2009)	59	INT-59	GU216906	None		E11ED, R20RK, F26FS, V31I, D41N, I72V, L74I, P90S, T112V, I113V, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, T218I, L234I, I251ICFS, S255N	A
	107	INT-107	GU216954	None		R20K, V31I, L45Q, I72V, L74I, T112V, I113V, S119P, T124G, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N	A
	157	INT-157	GU217004	None		E11D, R20K, V31I, I72V, L74I, T112V, I113V, H114T, T115AG, D116LQ, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, K215N, T218I, L234I, S255N	A
	368	INT-368	GU217215	None		K14R, A21T, I60M, I72V, L74I, T124A, T125A, K136KQ, D167E, H171Y, R187RG, L234I, S283G	A
	411	INT-411	GU217258	None		K14R, I72V, L74I, T112V, S119A, T124A, T125A, G134D, K136Q, D167E, K173R, V201I, E212I, T218I, L234I, S283G	A
Kousiappa (2009)	CY021	CY021	FJ388892	None		V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, H171Y, L234I, S255N	A
	CY057	CY057	FJ388906	None		D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, H171Y, V201I, L234I, S255N	A
	CY106	CY106	FJ388925	None		K14R, A21T, I60M, I72V, L74I, T112V, I113V, T124A, T125A, V126F, G134N, I135V, K136Q, K173R, V176L, V201I, L234I, S283G	A
	CY058	CY058	FJ388907	None		D3E, R20K, V31I, I72V, L74I, T112I, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, H171Y, V201I, L234I, S255N	A
Sichtig (2009)	4437	4437	FJ183485	None		K14R, V31I, L74I, L101I, T112V, I113V, T124A, T125A, I135IV, K136Q, G163A, G193E, V201I, L234I	A
	4443	4443	FJ183486	None		E11D, V31I, V32I, V37I, D41N, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, K211KR, T218I, L234I, S255N, A276AG	A
	16-E	16-E	FJ183491	None		D3DE, K7KQ, R20K, V31I, I72V, L74I, T112V, I113IV, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N	A
	17-E	17-E	FJ183492	None		V31I, L74I, T112V, T124A, T125A, G134N, K136T, D167DE, V201I, T206S, K219N, L234I	A
	20-E	20-E	FJ183543	None		D3E, E11D, R20K, V31I, I72V, L74I, K111N, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, L234I, S255N	A
	54-E	54-E	FJ183555	None		V31I, I60IL, I72V, L74I, T112V, I113V, T124A, T125S, V126M, G134N, K136Q, K173KR, I182V, V201I, T206S, I208L, L234I	A
	4876	4876	FJ183641	None		D3E, Q9QE, E11D, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136H, D167E, V201I, K215N, T218I, L234I, S255N	A
Avi (2010)	N71	N71	GQ926816	None	G163R	V31I, L74I, A91T, L101I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, V201I, I203M, T218I, L234I, D256E, S283G	A
	N78	N78	GQ926823	None		S24N, V31I, L74I, L101I, T112V, T124A, G134N, K136Q, V201I, T206S, T218I, L234I, D256E, Y271H, S283G	A
Carr (2010)	4038STN	01CM.4038STN	GU201508	None		E11D, E13D, A21T, V31I, I72V, L74I, I84M, P90S, T112V, T124A, K136Q, D167E, V201I, K219N, N222K, L234I, S283G	A
Tovanabutra (2010)	KECst_006	KECst_006	FJ623475	None		K14R, V31I, V32I, I72T, L74I, T112V, I113V, S119P, T124S, T125A, K136Q, D167E, V201I, I203M, K219N, N222K, S283G	A
	KECst_004	KECst_004	FJ623489	None		K14R, S24N, V31I, I72V, L74I, T112V, I113V, T124A, T125A, K136Q, D167E, V201I, S283G	A
Brenner (2011)	9022	9022	HQ207785	None		K14R, S24N, V31I, I72V, L74I, T112IV, I113V, T124A, T125A, G134D, K136Q, D167E, V201I, I208IM, E212EA, K219N, N222K, L234I, S283G	A
	9611	9611	HQ207798	None		K14R, S24N, V31I, M50IT, I72V, L74I, T112V, I113V, T124A, T125A, G134D, K136Q, D167E, V201I, E212A, K219N, N222K, L234I, S283G	A
Fernandez-Garcia (2012)	Irkutsk_5	Irkutsk_5	JQ292891	None		R20K, V32I, D41N, Q44H, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134D, K136Q, K156R, D167E, V201I, T218I, L234I, S255N	A
	RU01029	RU01029	JQ292892	None		D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N	A
	RUA001	RUA001	JQ292893	None		D3E, R20K, V31I, L63V, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N, V281M	A
	RUA007	RUA007	JQ292894	None		R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N, D270E	A
	RU_560_1125	RU_560_1125	JQ292895	None		D3E, R20K, D41N, I72V, L74I, T112V, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, T218I, L234I, S255N	A
	RU_915_1016	RU_915_1016	JQ292896	None		D3E, E11D, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, W132G, G134N, K136Q, D167E, V201I, T218I, L234I, S255N	A
	RU_915_1035	RU_915_1035	JQ292897	None		D3E, K7KQ, R20K, I72V, L74I, S81SR, T112V, I113V, S119P, T124S, T125A, W132WG, G134N, K136H, D167E, V201I, T218I, L234I, S255N	A
	RU_915_1038	RU_915_1038	JQ292898	None		D3E, R20K, V31I, L74I, T112V, S119P, T124N, T125A, G134N, K136Q, E157EG, D167E, V201I, L234I, S255N	A
	RU_915_1041	RU_915_1041	JQ292899	None		V32I, I72V, L74I, K111R, T112V, I113V, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N, V259I	A
	RU_SP_B_049	RU_SP_B_049	JQ292900	None		D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, L234I, S255N	A

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