<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype A
Gene IN
Mutation L74I
Rx II-naive
IncludeMixtures No
References 23
Patients 73
Isolates 74
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Alizon (1986)MALCGMAL MALCGX04415None   V31I, L74I, L101I, T112V, I113V, T124A, T125A, G134N, D167E, V201I, I203M, S230N, L234I, S283G, R284GA
Dowling (2002)KSM4024KSM4024AF457077None  T97AK14R, A21T, V31I, D41N, L74I, T112V, I113V, T124A, T125A, V126F, G134N, K136Q, E157Q, K160Q, D167E, V201I, Q216H, Y227F, L234V, S283GA
Masharsky (2003)A011698UA0116AF413987None   D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255NA
Meloni (2004)DDI579DDI579AY521629None  T97AK14R, A21T, V31I, I72V, L74I, T112V, T124A, T125A, V126M, G134N, D167E, V201I, L234I, V260I, S283GA
 DDJ360DDJ360AY521630None   K14R, A21T, V31I, I72V, L74I, T112V, T124A, T125A, V126M, G134D, D167E, V201I, L234I, V260I, S283GA
 DDJ369DDJ369AY521631None   K14R, A21T, V31I, M50K, I72V, L74I, T112V, T124A, T125A, G134N, K136Q, D167E, V201I, K211Q, T218I, L234I, S283GA
Adojaan (2005)EST2002_3942002_394DQ167216None   D3E, R20K, V31I, I72V, L74I, T112V, I113V, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, D232NA
Carr (2005)02UZ066302UZ0663AY829210None   D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255NA
Njai (2006)MP141199CM.1411AM279396None  T97AV31I, L63M, I72V, L74I, T112V, I113L, T124N, T125A, V126M, G134N, K136Q, L158LF, D167E, V201I, I203M, T218S, L234IA
Saad (2006)01UADN12101UADN121DQ823358None   V32I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255NA
 01UADN13901UADN139DQ823357None   D3E, R20K, V31I, I72V, L74I, T112V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, L234I, S255N, S283GA
 01UAKV25401UAKV254DQ823361None   D3E, R20K, V31I, I72V, L74I, L101LV, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255NA
 01UAPol29301UAPol293DQ823359None   D3E, E11D, R20K, A21T, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, K211R, T218I, L234I, P238S, S255NA
 01UAPol29401UAPol294DQ823356None   D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255NA
 01UAPol30301UAPol303DQ823360None   D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, W243X, S255NA
 01UAOD1001UAOD10DQ823365None   D3E, K14R, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, T218I, L234I, S255NA
 01UAOD3501UAOD35DQ823366None   D3E, K7Q, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, L234I, S255NA
 01UAOD8901UAOD89DQ823367None   D3E, R20K, L28I, L45Q, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, L234I, S255NA
Badreddine (2007)J11469SB_J11469DQ375282None   E11D, K14R, A21AT, A23V, V31I, V32I, S39N, D41N, M50I, I72V, L74I, L101I, T112V, T125A, G134D, K136Q, D167E, V201I, K211KR, Q216H, N222H, L234I, D279G, S283GA
Eyzaguirre (2007)KZYUZ30041302Y300413EF589040None   D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, G163E, D167E, V201I, T218I, L234I, S255NA
 KZYUZ30042502Y300425EF589041None   D3E, D6N, R20K, V31I, E35K, M50T, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255NA
 KZKAR30043502K300435EF589042None   D3E, R20K, V31I, H51P, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255NA
 KZPAV30048002P300480EF589043None   D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, K160R, D167E, V201I, T218I, L234I, S255NA
 KZPAV30049702P300497EF589039None  V54ID3E, S17N, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255NA
 KZPAV30050202P300502EF589044None   D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255NA
Brennan (2008)124-33124-33EU618078None   K14R, A21T, S39C, L63I, I72V, L74I, T112V, I113V, S119ST, T124A, T125A, V126M, G134N, I135V, D167E, V201I, K211R, Q216H, L234I, S283GA
 193-6193-6EU618116None   E11D, E13ED, K14KR, A21T, V31I, L63I, I72V, L74I, T112V, T124A, T125A, V126M, G134DN, I135V, D167E, V201I, Q216H, L234I, A265AV, S283GA
 239-40239-40EU618123None   E11D, K14R, A21T, M22MI, A23V, V31I, V32I, D41N, M50I, I72V, L74I, T112V, T124A, T125A, G134D, K136Q, D167E, V201I, L234I, S283G, D288NA
 393-17393-17EU618170None   V31I, M50I, L63I, I72V, L74I, F100Y, T112I, T124A, T125A, K136Q, D167E, V201I, L234I, S255NA
 476-16476-16EU618204None   K14R, A21T, V31I, I72V, L74I, T112I, T124G, T125A, G134N, K136T, D167E, V201I, L234I, S283GA
 4832-94832-9EU618207None   E11D, V31I, V32I, L45I, I72IV, L74I, I89IV, T112V, T124TA, T125A, V126M, G134D, G163E, G193GE, V201I, L234I, N254KA
 ABB08-96ABB08-96EU618497None   K14R, A21T, V31I, L63V, I72V, L74I, T112V, S119G, T122I, T124A, T125A, K136Q, D167E, Q216H, L234I, A265V, S283GA
 ABB191-98ABB191-98EU618617None   K14R, A21T, A23V, D41N, L63I, I72V, L74I, T112V, T124A, T125A, V126M, G134D, I135V, D167E, V201I, Q216H, L234I, S255G, R269K, S283GA
Brumme (2009)INT_3927INT_3927FJ813378None   K14R, S17C, I72V, L74I, T112IV, T124A, T125A, G134N, K136Q, D167E, V201I, L234I, S283GA
Eshleman (2009)ABB08-96ABB08-96FJ480267None   K14R, A21T, V31I, L63V, I72V, L74I, T112V, S119G, T122I, T124A, T125A, K136Q, D167E, Q216H, L234I, A265V, S283GA
 ABB213ABB213FJ480319None   E11D, K14R, A21T, V31I, M50MV, I72V, L74I, T112V, T124A, T125A, V126M, G134N, K136Q, D167E, V201I, I208M, L234I, S283GA
Garrido (2009)59INT-59GU216906None   E11ED, R20RK, F26FS, V31I, D41N, I72V, L74I, P90S, T112V, I113V, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, T218I, L234I, I251ICFS, S255NA
 107INT-107GU216954None   R20K, V31I, L45Q, I72V, L74I, T112V, I113V, S119P, T124G, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255NA
 157INT-157GU217004None   E11D, R20K, V31I, I72V, L74I, T112V, I113V, H114T, T115AG, D116LQ, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, K215N, T218I, L234I, S255NA
 368INT-368GU217215None   K14R, A21T, I60M, I72V, L74I, T124A, T125A, K136KQ, D167E, H171Y, R187RG, L234I, S283GA
 411INT-411GU217258None   K14R, I72V, L74I, T112V, S119A, T124A, T125A, G134D, K136Q, D167E, K173R, V201I, E212I, T218I, L234I, S283GA
Kousiappa (2009)CY021CY021FJ388892None   V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, H171Y, L234I, S255NA
 CY057CY057FJ388906None   D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, H171Y, V201I, L234I, S255NA
 CY106CY106FJ388925None   K14R, A21T, I60M, I72V, L74I, T112V, I113V, T124A, T125A, V126F, G134N, I135V, K136Q, K173R, V176L, V201I, L234I, S283GA
 CY058CY058FJ388907None   D3E, R20K, V31I, I72V, L74I, T112I, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, H171Y, V201I, L234I, S255NA
Sichtig (2009)44374437FJ183485None   K14R, V31I, L74I, L101I, T112V, I113V, T124A, T125A, I135IV, K136Q, G163A, G193E, V201I, L234IA
 44434443FJ183486None   E11D, V31I, V32I, V37I, D41N, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, K211KR, T218I, L234I, S255N, A276AGA
 16-E16-EFJ183491None   D3DE, K7KQ, R20K, V31I, I72V, L74I, T112V, I113IV, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255NA
 17-E17-EFJ183492None   V31I, L74I, T112V, T124A, T125A, G134N, K136T, D167DE, V201I, T206S, K219N, L234IA
 20-E20-EFJ183543None   D3E, E11D, R20K, V31I, I72V, L74I, K111N, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, L234I, S255NA
 54-E54-EFJ183555None   V31I, I60IL, I72V, L74I, T112V, I113V, T124A, T125S, V126M, G134N, K136Q, K173KR, I182V, V201I, T206S, I208L, L234IA
 48764876FJ183641None   D3E, Q9QE, E11D, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136H, D167E, V201I, K215N, T218I, L234I, S255NA
Avi (2010)N71N71GQ926816None  G163RV31I, L74I, A91T, L101I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, V201I, I203M, T218I, L234I, D256E, S283GA
 N78N78GQ926823None   S24N, V31I, L74I, L101I, T112V, T124A, G134N, K136Q, V201I, T206S, T218I, L234I, D256E, Y271H, S283GA
Carr (2010)4038STN01CM.4038STNGU201508None   E11D, E13D, A21T, V31I, I72V, L74I, I84M, P90S, T112V, T124A, K136Q, D167E, V201I, K219N, N222K, L234I, S283GA
Tovanabutra (2010)KECst_006KECst_006FJ623475None   K14R, V31I, V32I, I72T, L74I, T112V, I113V, S119P, T124S, T125A, K136Q, D167E, V201I, I203M, K219N, N222K, S283GA
 KECst_004KECst_004FJ623489None   K14R, S24N, V31I, I72V, L74I, T112V, I113V, T124A, T125A, K136Q, D167E, V201I, S283GA
Brenner (2011)90229022HQ207785None   K14R, S24N, V31I, I72V, L74I, T112IV, I113V, T124A, T125A, G134D, K136Q, D167E, V201I, I208IM, E212EA, K219N, N222K, L234I, S283GA
 96119611HQ207798None   K14R, S24N, V31I, M50IT, I72V, L74I, T112V, I113V, T124A, T125A, G134D, K136Q, D167E, V201I, E212A, K219N, N222K, L234I, S283GA
Fernandez-Garcia (2012)Irkutsk_5Irkutsk_5JQ292891None   R20K, V32I, D41N, Q44H, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134D, K136Q, K156R, D167E, V201I, T218I, L234I, S255NA
 RU01029RU01029JQ292892None   D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255NA
 RUA001RUA001JQ292893None   D3E, R20K, V31I, L63V, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N, V281MA
 RUA007RUA007JQ292894None   R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N, D270EA
 RU_560_1125RU_560_1125JQ292895None   D3E, R20K, D41N, I72V, L74I, T112V, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, T218I, L234I, S255NA
 RU_915_1016RU_915_1016JQ292896None   D3E, E11D, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, W132G, G134N, K136Q, D167E, V201I, T218I, L234I, S255NA
 RU_915_1035RU_915_1035JQ292897None   D3E, K7KQ, R20K, I72V, L74I, S81SR, T112V, I113V, S119P, T124S, T125A, W132WG, G134N, K136H, D167E, V201I, T218I, L234I, S255NA
 RU_915_1038RU_915_1038JQ292898None   D3E, R20K, V31I, L74I, T112V, S119P, T124N, T125A, G134N, K136Q, E157EG, D167E, V201I, L234I, S255NA
 RU_915_1041RU_915_1041JQ292899None   V32I, I72V, L74I, K111R, T112V, I113V, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N, V259IA
 RU_SP_B_049RU_SP_B_049JQ292900None   D3E, R20K, V31I, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, L234I, S255NA
Jahanbakhsh (2012)THR02THR02INTAB716143None   K14R, E35Q, S39N, I60M, I72V, L74I, G106GA, K111R, T112V, I113V, T124A, T125A, V126F, G134S, K136Q, I141IF, D167EK, I191IM, S195T, V201I, I203M, S283G, R284RGA
Reigadas (2013)317317JX425438None   K14R, A21T, S39C, M50R, I72V, L74I, G106A, T112V, S119T, T124A, T125A, V126M, G134N, K136Q, V165I, G193E, V201I, T206S, T210I, T218S, Q221E, L234I, S283GA
 344344JX425465None   E11D, K14R, A21T, V31I, D41N, S57R, I72V, L74I, A91T, T112V, T124A, T125A, G134N, K136Q, I182V, V201I, L234I, S283GA
 605605JX425850None   K14R, V31I, M50I, I72V, L74I, T112V, I113IV, S119P, T122TI, T124A, T125A, V126M, G134DN, K136KQ, I161IT, G163GW, Q164QKLM, V165VL, D167EK, V201I, L234I, D256EA
 608608JX425853None   K14R, S39C, L63V, I72V, L74I, E96D, T112I, T124A, K136Q, V201I, L234I, S283GA