<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype A
Gene IN
Mutation T206S
Rx II-naive
IncludeMixtures No
References 27
Patients 55
Isolates 55
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Gao (1996)92UG03792UG037U51190None   K14R, V31I, I72V, I84V, T112V, I113V, T124A, T125A, G134N, I135V, D167E, V201I, T206S, I208L, N222K, Y226C, L234I, A265V, R269K, S283GA
Wilbe (2002)CM-449696CM-4496AF492623None   K14R, K34R, M50I, L101LI, T112V, S119T, T124A, T125A, G134N, D167E, K173R, T206S, L234I, N254K, S283GA
Kijak (2004)0190MA01CM.0190AY371145None  L68IE11D, K14R, V31I, D41N, M50I, I72V, L101I, T112V, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, T218I, L234I, S283G, D288NA
 4118STN02CM.4118AY371153None   K14R, A21T, V31I, S39N, L101I, T112V, T124S, G134N, K136Q, D167E, V201I, T206S, T218I, L234I, S283G, R284G, D286AA
 1152NG01CM.1152AY371163None   E11D, K14R, A21T, A23V, S24N, D25E, V31I, M50I, I72V, L101I, T112V, T124A, T125A, G134N, K136Q, V165I, D167E, V201I, T206S, D207E, T218I, I220V, L234I, S283GA
Meloni (2004)DDJ362DDJ362AY521632None   S24N, V31I, V32I, I72V, L74I, T112V, T124A, T125A, G134N, I135V, K136T, V165I, D167E, V201I, T206S, L234I, D279G, S283GA
Njai (2006)MP102098CM.1020AM279379None   M50R, L63I, L74I, L101I, T112V, S119A, T124A, T125A, G134S, K136N, D167E, V201I, T206S, I208L, T218I, L234VA
Brennan (2008)AB1073AB1073EU618473None   K14R, A21T, V31I, I72V, L101I, T112V, T124G, T125A, G134N, K136Q, D167E, V201I, T206S, I208L, L234I, S283GA
 AB268AB268EU618479None   E11D, K14R, A21T, L28I, V31I, V32I, M50I, I72V, I84L, T112V, I113V, T124A, T125A, V126F, G134S, I135V, K136Q, V201I, T206S, L234I, S255N, S283GA
 ABB43-96ABB43-96EU618530None  T97TAS17N, V31I, L101LI, T112V, T124G, T125A, G134N, K136Q, D167E, V201I, T206S, Y227F, L234I, S255N, D256E, S283GA
 ABB73-96ABB73-96EU618558None   E11D, K14R, A21T, A23V, V31I, D41N, M50I, I72V, T112V, I113V, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, L234I, S283G, D288NA
Land (2008)ML2000ML2000EU110093None   S17N, V31I, I72V, L101I, T112V, T124A, T125A, I135L, K136Q, F181L, K188KR, V201I, T206S, D256DE, I268L, D270H, S283GA
Van Laethem (2008)AR04-1158AR04-1158EU882801None   E11D, K14R, S24H, V31I, L101I, T112IV, S119P, T122I, T124TA, T125S, I135V, K136Q, V201I, T206S, K215R, L234I, D256E, S283GA
Garrido (2009)15INT-15GU216862None   K7E, E11D, S24N, I72V, L74I, T112I, T124A, T125A, V126M, K136Q, M154ML, V201I, T206S, Q209R, L234I, S255N, D256EA
Niama (2009)97GA.TB45GA.TB45FN392877None   K14KR, V31I, L101I, T124A, T125A, K136H, V201I, T206S, D207E, I220V, L234I, A265V, S283GA
Sichtig (2009)55-E55-EFJ183551None   S24H, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, D207E, L234I, D256DEA
 57-E57-EFJ183552None   E11D, K14R, S24N, V31I, M50I, A91E, L101I, T112V, S119R, T122I, T124N, T125A, G134N, K136T, V165I, V201I, T206S, L234IA
 54-E54-EFJ183555None   V31I, I60IL, I72V, L74I, T112V, I113V, T124A, T125S, V126M, G134N, K136Q, K173KR, I182V, V201I, T206S, I208L, L234IA
 52-E52-EFJ183639None   V31VA, Y99H, L101V, T112V, H114HR, S119P, T124A, T125A, G134D, I135V, F181L, V201I, T206S, I208L, T218I, L234I, D256EA
Avi (2010)N69N69GQ926814None   R20K, V31I, I72V, L74I, T112V, T124A, T125A, G134N, K136T, V201I, T206S, T218I, L234I, S255NA
Fish (2010)P3509ZAP35GQ872493None   K14R, S24N, S39C, I60M, I72V, T112V, I113V, T124A, T125A, K136Q, V201I, T206S, T218I, Q221R, L234I, S283GA
Tovanabutra (2010)KECst_013KECst_013FJ623485None   K14R, V31I, I72V, L101I, T112V, I113V, S119P, T124A, T125A, I135V, K136Q, D167E, G193E, V201I, T206S, L234I, D278N, S283GA
 KECst_001KECst_001FJ623487None   K14R, V31I, I72V, L101I, T112V, I113V, T124A, T125A, K136R, K156N, G193R, V201I, T206S, A265V, S283GA
Brenner (2011)89898989HQ207784None   E11D, E13D, S24N, D25E, V31I, M50L, L101I, G106A, T112V, S119T, T124TA, K136Q, V165I, D167E, V201I, T206S, L234I, S255NA
Jahanbakhsh (2012)THR19THR19INTAB716159None   K14R, E35Q, S39N, I60M, T112V, I113V, T124A, T125A, K136Q, D167EK, E198Q, V201I, T206S, S230SN, A265AT, R269RK, S283DGA
Zhao (2012)LPH27MFLPH27MFJN864049None   E11D, A23V, D25E, V31I, D41N, M50I, I72V, L101I, T112V, S119T, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, I208L, Q216H, L234I, S255Q, S283G, R284G, E287QA
 LB054LB054JN864059None   K14R, V31I, D41N, M50I, I72V, L101I, T112V, S119P, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, T218S, I220L, Y227F, L234I, S283G, D288NA
Reigadas (2013)317317JX425438None   K14R, A21T, S39C, M50R, I72V, L74I, G106A, T112V, S119T, T124A, T125A, V126M, G134N, K136Q, V165I, G193E, V201I, T206S, T210I, T218S, Q221E, L234I, S283GA
 319319JX425440None   S24N, V31I, L63I, I72V, L74I, K111KQ, T112MV, T124A, T125A, G134N, K136T, D167E, V201I, T206S, E212A, L234I, D256E, S283GA
 335335JX425456None   K14R, A23V, S24N, V31I, D41S, M50I, I72V, L101I, T112V, I113V, T124A, T125A, G134D, K136Q, D167E, E170K, V201I, T206S, L234I, S283G, D288NA
 336336JX425457None   V31I, L74LI, L101I, G106GA, T112M, S119SAGT, T122TI, T124A, T125A, G134N, D167E, V201I, T206S, D207E, K211Q, E212A, T218L, K219Q, Q221QK, L234I, S283G, D286NA
 347347JX425468None  L68IK14R, A21T, A23V, V31I, S39N, I72V, A98AE, L101I, T112V, T124A, T125A, G134N, I135V, K136Q, D167DE, V201I, T206S, Q221T, L234I, S283GA
 601601JX425846None   V31I, I72V, T112V, T124A, T125A, G134N, I135V, E157Q, K160Q, F181L, V201I, T206S, L234I, A265V, R269K, S283GA
 602602JX425847None   K14R, S24H, I72V, L101I, T112V, S119P, T124A, I135V, K136Q, K173R, V201I, T206S, K215R, T218I, L234I, D256E, S283GA
 607607JX425852None   K14R, V31I, L45Q, I72V, L74I, E96D, T112V, T124A, T125A, V126M, G134N, I135V, K136Q, V201I, T206S, E212HQ, L234I, D256E, S283G, D286EA
 613613JX425857None   K14R, A21T, V31I, L63LV, I72IV, I84M, T112V, I113V, T124A, T125A, K136Q, V201I, T206S, Q221K, L234I, S255N, S283GA
 4163841638JX451916None   E11D, K14R, A21T, V31I, D41N, M50I, I72V, I84L, L101I, T112V, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, I208L, E212I, Q216H, K219N, L234I, S283G, D288NA
Foster (2014)1279212792JN417240None   E11D, K14R, A21T, I72V, T112V, I113V, T124A, T125A, G134N, K136Q, G163T, V201I, A205S, T206S, V260L, D278S, V281M, S283GA
Hora (2015)DE02210CM006DE02210CM006KP109500None   K14R, A21T, V31I, D41N, M50I, I72V, L101I, T112V, S119P, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, T218S, I220L, Y227F, L234I, S283G, D288NA
 DEMA07UG005DEMA07UG005KC596070None   K14R, V31I, I60M, T112V, I113V, T124A, T125A, V126F, G134N, K136Q, D167E, K173R, V201I, T206S, D207E, S255Q, S283GA
 DE02210CM014DE02210CM014KF716463None   K14R, A21T, V31I, M50I, I72V, L101I, T112V, S119P, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, T210S, T218S, I220L, Y227F, L234I, S283G, D288NA
Tongo (2015)BS13BS13KR017772None   K14R, A21T, E69G, I72V, L74I, T112V, T124A, T125A, V126M, G134N, I135V, K136T, D167E, V201I, T206S, I208L, Q221T, L234I, S255N, A265V, S283G, R284G, D286AA
Billings (2016)KE196199V6KE196199V6KT022378None   K7R, K14R, A21T, V31I, I72V, T112V, I113V, T124A, T125A, V126F, G134Q, I135V, D167E, K188R, V201I, T206S, T218S, K219N, I220L, N222K, L234I, I268L, S283GA
 KE809646V6KE809646V6KT022416None   K14R, D25E, V31I, V54L, I72V, T112V, I113V, T124A, T125A, D167E, V201I, T206S, L234V, D256E, S283GA
 KE884468V5KE884468V5KT022377None   E11D, K14R, V31I, V32I, I72V, L101I, T112V, I113V, T124A, T125A, G134D, K136Q, G163T, D167E, V201I, T206S, I208L, E212A, S283GA
Billings (2016)CO6637V7CO6637V7KX907414None   D3E, K7I, K14R, A21T, V31I, E35Q, S39N, I60M, I72V, I113V, S119T, T124A, T125A, V126F, G134N, I135V, K136Q, F139Y, D167E, K173R, V201I, T206S, Q216H, L234I, A265V, I268V, S283G, D286NA
 CO0098V3CO0098V3KX907340None   K14R, A21T, V31I, M50I, I60M, I72V, I113V, S119T, T124A, T125A, V126F, G134N, K136Q, F139Y, D167E, V201I, T206S, T218I, L234I, S283D, D288NA
Gashnikova (2016)5IN_5KX574446None   D3E, E11D, R20K, V31VI, V32VI, L63LV, I72IV, L74I, T112I, I113V, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, T206S, L234I, S255NA
Gashnikova (2016)Tyumen64Tyumen64KX640239None   D3E, R20K, V31I, S39N, H51HR, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T206S, T218I, L234I, K244R, S255NA
 Tyumen14Tyumen14KX640197None   S24G, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, H171Q, V201I, T206S, L234I, S255NA
Heipertz (2016)NG010499NG010499KX389622None   V31I, L101I, G106A, T112V, T124A, T125A, G134D, D167E, V201I, T206S, D207E, I208L, L234I, S283GA
 NG020382NG020382KX389616None   E11D, H16HR, D25E, V31I, I72V, L74I, T112V, T124A, T125A, V126M, G134D, I135V, K136H, F181L, V201I, T206S, L234I, S283GA
 NG010131NG010131KX389633None  L74MK14R, V31I, K111T, T112V, T124A, T125A, K136Q, D167E, T206S, I208L, L234I, D278G, R284G, D288NA
Rodgers (2017)CG-0086-01VCG-0086-01VKY365208None  T97AV31I, M50I, L74I, L101I, T112V, I113L, T124G, T125A, G134D, T206S, T218S, L234I, S283GA
 CG-0378-02VCG-0378-02VKY392771None   K14R, V31I, I72V, L101I, G106A, S119T, T124A, T125A, G134D, I135V, D167E, V201I, T206S, D207E, L234I, D253E, S255N, S283G, R284G, D286AA