<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype A
Gene IN
Mutation T206S
Rx II-naive
IncludeMixtures No
References 33
Patients 100
Isolates 100
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Gao (1996)92UG03792UG037U51190None   K14R, V31I, I72V, I84V, T112V, I113V, T124A, T125A, G134N, I135V, D167E, V201I, T206S, I208L, N222K, Y226C, L234I, A265V, R269K, S283GA
Dowling (2002)KER2008KER2008AF457052None   K14R, S17N, L28I, V31I, V32I, I60M, I72V, T112V, I113V, T124A, T125A, V126F, G134N, I135V, K136Q, F139Y, V201I, T206S, S283GA
Wilbe (2002)CM-449696CM-4496AF492623None   K14R, K34R, M50I, L101LI, T112V, S119T, T124A, T125A, G134N, D167E, K173R, T206S, L234I, N254K, S283GA
Kijak (2004)0190MA01CM.0190AY371145None  L68IE11D, K14R, V31I, D41N, M50I, I72V, L101I, T112V, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, T218I, L234I, S283G, D288NA
 4041HAN01CM.4041AY371150None   K14R, A21T, V31I, S39N, M50R, L101I, T112V, T124S, G134D, K136Q, D167E, T206S, T218I, L234I, S283G, R284G, D286AA
 4118STN02CM.4118AY371153None   K14R, A21T, V31I, S39N, L101I, T112V, T124S, G134N, K136Q, D167E, V201I, T206S, T218I, L234I, S283G, R284G, D286AA
 1152NG01CM.1152AY371163None   E11D, K14R, A21T, A23V, S24N, D25E, V31I, M50I, I72V, L101I, T112V, T124A, T125A, G134N, K136Q, V165I, D167E, V201I, T206S, D207E, T218I, I220V, L234I, S283GA
Meloni (2004)DDJ362DDJ362AY521632None   S24N, V31I, V32I, I72V, L74I, T112V, T124A, T125A, G134N, I135V, K136T, V165I, D167E, V201I, T206S, L234I, D279G, S283GA
Njai (2006)MP102098CM.1020AM279379None   M50R, L63I, L74I, L101I, T112V, S119A, T124A, T125A, G134S, K136N, D167E, V201I, T206S, I208L, T218I, L234VA
Brennan (2008)119-28119-28EU618073None   K14R, V31I, L101I, T112V, I113IL, S119SG, T124G, T125A, G134N, K136Q, D167E, T206S, I208IL, T210TI, K211KR, L234I, S283G, R284G, D288NA
 531-2531-2EU618234None   K14R, V31I, S39N, L45I, M50T, I60M, I72V, L74I, A91G, K111T, T112V, T124G, T125A, V126M, G134N, K136Q, G163E, V201I, T206S, T218I, L234I, D279G, S283G, D286AA
 803-12803-12EU618301None   E11D, K14R, A21T, V31I, D41N, M50I, I72V, I84IM, L101I, T112V, S119P, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, Q214E, Q221N, L234I, S283G, D286E, D288NA
 A1705A1705EU618421None   E11D, K14R, A23V, S24N, D41N, M50I, I72V, L101I, T112V, T122I, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, T218I, L234I, D270E, S283G, D286E, D288NA
 AB1073AB1073EU618473None   K14R, A21T, V31I, I72V, L101I, T112V, T124G, T125A, G134N, K136Q, D167E, V201I, T206S, I208L, L234I, S283GA
 AB268AB268EU618479None   E11D, K14R, A21T, L28I, V31I, V32I, M50I, I72V, I84L, T112V, I113V, T124A, T125A, V126F, G134S, I135V, K136Q, V201I, T206S, L234I, S255N, S283GA
 ABB43-96ABB43-96EU618530None  T97TAS17N, V31I, L101LI, T112V, T124G, T125A, G134N, K136Q, D167E, V201I, T206S, Y227F, L234I, S255N, D256E, S283GA
 ABB73-96ABB73-96EU618558None   E11D, K14R, A21T, A23V, V31I, D41N, M50I, I72V, T112V, I113V, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, L234I, S283G, D288NA
Land (2008)ML2000ML2000EU110093None   S17N, V31I, I72V, L101I, T112V, T124A, T125A, I135L, K136Q, F181L, K188KR, V201I, T206S, D256DE, I268L, D270H, S283GA
Van Laethem (2008)AR04-1158AR04-1158EU882801None   E11D, K14R, S24H, V31I, L101I, T112IV, S119P, T122I, T124TA, T125S, I135V, K136Q, V201I, T206S, K215R, L234I, D256E, S283GA
Brumme (2009)Q4515Q4515GQ372109None  P145PLK14R, R20K, K34R, L101I, T112V, T124A, T125A, A133AG, G134N, I135V, K136Q, D167E, V201I, T206S, T210TA, L234I, S255N, D270E, D278A, S283G, R284G, D288NA
Eshleman (2009)ABB144-98ABB144-98FJ480308None   E11D, S24N, P30S, V31I, M50I, I60IMV, L101I, T112V, T124S, T125A, G134N, K136T, V165I, D167DE, V201I, T206S, L234I, D256E, S283G, Q285QHA
Garrido (2009)15INT-15GU216862None   K7E, E11D, S24N, I72V, L74I, T112I, T124A, T125A, V126M, K136Q, M154ML, V201I, T206S, Q209R, L234I, S255N, D256EA
 92INT-92GU216939None   A21T, M22I, N27I, V31I, V32I, D41N, M50I, I72V, L101I, T112V, T124A, T125A, G134D, K136Q, I161IT, D167E, V201I, T206S, D207E, Q221N, L234I, I268LA
 351INT-351GU217198None   H16HR, S24N, L63I, L74I, T112V, T124S, T125A, G134D, K136T, K156KR, E157Q, H171Q, V201I, T206S, I220IV, L234I, D256E, S283GA
 370INT-370GU217217None   K14R, A21T, S39SN, M50MI, I60M, I72V, L101I, T112V, T124A, T125A, K136Q, V201I, T206S, D207E, K211R, K219KR, L234I, V259VA, R269K, S283GA
Niama (2009)97CD.MBS30CD.MBS30FN392875None   A21T, P30S, L74I, T124A, T125A, G134D, D167E, V201I, T206S, T218S, I220L, Q221H, N222R, L234I, A265AV, I268L, M275V, S283GA
 97GA.TB45GA.TB45FN392877None   K14KR, V31I, L101I, T124A, T125A, K136H, V201I, T206S, D207E, I220V, L234I, A265V, S283GA
Sichtig (2009)55-E55-EFJ183551None   S24H, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, D207E, L234I, D256DEA
 57-E57-EFJ183552None   E11D, K14R, S24N, V31I, M50I, A91E, L101I, T112V, S119R, T122I, T124N, T125A, G134N, K136T, V165I, V201I, T206S, L234IA
 54-E54-EFJ183555None   V31I, I60IL, I72V, L74I, T112V, I113V, T124A, T125S, V126M, G134N, K136Q, K173KR, I182V, V201I, T206S, I208L, L234IA
 52-E52-EFJ183639None   V31VA, Y99H, L101V, T112V, H114HR, S119P, T124A, T125A, G134D, I135V, F181L, V201I, T206S, I208L, T218I, L234I, D256EA
Avi (2010)N69N69GQ926814None   R20K, V31I, I72V, L74I, T112V, T124A, T125A, G134N, K136T, V201I, T206S, T218I, L234I, S255NA
Fish (2010)P3509ZAP35GQ872493None   K14R, S24N, S39C, I60M, I72V, T112V, I113V, T124A, T125A, K136Q, V201I, T206S, T218I, Q221R, L234I, S283GA
Tovanabutra (2010)KECst_013KECst_013FJ623485None   K14R, V31I, I72V, L101I, T112V, I113V, S119P, T124A, T125A, I135V, K136Q, D167E, G193E, V201I, T206S, L234I, D278N, S283GA
 KECst_001KECst_001FJ623487None   K14R, V31I, I72V, L101I, T112V, I113V, T124A, T125A, K136R, K156N, G193R, V201I, T206S, A265V, S283GA
 KECst_027KECst_027FJ623492None   S24H, I72V, S81G, T112V, S119P, T122I, T125P, I135V, V201I, A205S, T206S, D207E, I208L, K215R, L234IA
Brenner (2011)89898989HQ207784None   E11D, E13D, S24N, D25E, V31I, M50L, L101I, G106A, T112V, S119T, T124TA, K136Q, V165I, D167E, V201I, T206S, L234I, S255NA
Jahanbakhsh (2012)THR19THR19INTAB716159None   K14R, E35Q, S39N, I60M, T112V, I113V, T124A, T125A, K136Q, D167EK, E198Q, V201I, T206S, S230SN, A265AT, R269RK, S283DGA
Zhao (2012)LB013LB013JN864058None   K14R, A21T, D41N, M50I, I72V, L101I, T112V, S119T, T124S, T125A, G134D, K136Q, D167E, G190R, G192E, T206S, E212L, T218I, K219Q, L234I, S283G, D286GA
 LPH27MFLPH27MFJN864049None   E11D, A23V, D25E, V31I, D41N, M50I, I72V, L101I, T112V, S119T, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, I208L, Q216H, L234I, S255Q, S283G, R284G, E287QA
 LB054LB054JN864059None   K14R, V31I, D41N, M50I, I72V, L101I, T112V, S119P, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, T218S, I220L, Y227F, L234I, S283G, D288NA
Reigadas (2013)317317JX425438None   K14R, A21T, S39C, M50R, I72V, L74I, G106A, T112V, S119T, T124A, T125A, V126M, G134N, K136Q, V165I, G193E, V201I, T206S, T210I, T218S, Q221E, L234I, S283GA
 319319JX425440None   S24N, V31I, L63I, I72V, L74I, K111KQ, T112MV, T124A, T125A, G134N, K136T, D167E, V201I, T206S, E212A, L234I, D256E, S283GA
 335335JX425456None   K14R, A23V, S24N, V31I, D41S, M50I, I72V, L101I, T112V, I113V, T124A, T125A, G134D, K136Q, D167E, E170K, V201I, T206S, L234I, S283G, D288NA
 336336JX425457None   V31I, L74LI, L101I, G106GA, T112M, S119SAGT, T122TI, T124A, T125A, G134N, D167E, V201I, T206S, D207E, K211Q, E212A, T218L, K219Q, Q221QK, L234I, S283G, D286NA
 347347JX425468None  L68IK14R, A21T, A23V, V31I, S39N, I72V, A98AE, L101I, T112V, T124A, T125A, G134N, I135V, K136Q, D167DE, V201I, T206S, Q221T, L234I, S283GA
 601601JX425846None   V31I, I72V, T112V, T124A, T125A, G134N, I135V, E157Q, K160Q, F181L, V201I, T206S, L234I, A265V, R269K, S283GA
 602602JX425847None   K14R, S24H, I72V, L101I, T112V, S119P, T124A, I135V, K136Q, K173R, V201I, T206S, K215R, T218I, L234I, D256E, S283GA
 607607JX425852None   K14R, V31I, L45Q, I72V, L74I, E96D, T112V, T124A, T125A, V126M, G134N, I135V, K136Q, V201I, T206S, E212HQ, L234I, D256E, S283G, D286EA
 613613JX425857None   K14R, A21T, V31I, L63LV, I72IV, I84M, T112V, I113V, T124A, T125A, K136Q, V201I, T206S, Q221K, L234I, S255N, S283GA
 4163841638JX451916None   E11D, K14R, A21T, V31I, D41N, M50I, I72V, I84L, L101I, T112V, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, I208L, E212I, Q216H, K219N, L234I, S283G, D288NA
Foster (2014)1279212792JN417240None   E11D, K14R, A21T, I72V, T112V, I113V, T124A, T125A, G134N, K136Q, G163T, V201I, A205S, T206S, V260L, D278S, V281M, S283GA
Hora (2015)DE02210CM006DE02210CM006KP109500None   K14R, A21T, V31I, D41N, M50I, I72V, L101I, T112V, S119P, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, T218S, I220L, Y227F, L234I, S283G, D288NA
 DEMA07UG005DEMA07UG005KC596070None   K14R, V31I, I60M, T112V, I113V, T124A, T125A, V126F, G134N, K136Q, D167E, K173R, V201I, T206S, D207E, S255Q, S283GA
 DE02210CM014DE02210CM014KF716463None   K14R, A21T, V31I, M50I, I72V, L101I, T112V, S119P, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, T210S, T218S, I220L, Y227F, L234I, S283G, D288NA
Tongo (2015)BS13BS13KR017772None   K14R, A21T, E69G, I72V, L74I, T112V, T124A, T125A, V126M, G134N, I135V, K136T, D167E, V201I, T206S, I208L, Q221T, L234I, S255N, A265V, S283G, R284G, D286AA
Billings (2016)KE196199V6KE196199V6KT022378None   K7R, K14R, A21T, V31I, I72V, T112V, I113V, T124A, T125A, V126F, G134Q, I135V, D167E, K188R, V201I, T206S, T218S, K219N, I220L, N222K, L234I, I268L, S283GA
 KE809646V6KE809646V6KT022416None   K14R, D25E, V31I, V54L, I72V, T112V, I113V, T124A, T125A, D167E, V201I, T206S, L234V, D256E, S283GA
 KE884468V5KE884468V5KT022377None   E11D, K14R, V31I, V32I, I72V, L101I, T112V, I113V, T124A, T125A, G134D, K136Q, G163T, D167E, V201I, T206S, I208L, E212A, S283GA
Billings (2016)CO6637V7CO6637V7KX907414None   D3E, K7I, K14R, A21T, V31I, E35Q, S39N, I60M, I72V, I113V, S119T, T124A, T125A, V126F, G134N, I135V, K136Q, F139Y, D167E, K173R, V201I, T206S, Q216H, L234I, A265V, I268V, S283G, D286NA
 CO0098V3CO0098V3KX907340None   K14R, A21T, V31I, M50I, I60M, I72V, I113V, S119T, T124A, T125A, V126F, G134N, K136Q, F139Y, D167E, V201I, T206S, T218I, L234I, S283D, D288NA
Chen (2016)PK036PK036KX232626None  L74MK14R, R20K, V31I, D41N, I84L, T112V, I113V, T124A, T125A, V126F, I135A, D167E, V201I, I204L, T206S, K211R, T218S, N222K, Y227F, L234I, S255G, M275V, S283G, R284GA
 PK034PK034KX232624None   E11D, K14R, R20K, V31I, T112V, I113V, T124A, T125A, V126F, G134S, I135V, D167E, V201I, I204L, T206S, K211R, N222K, Y227F, L234I, D253H, S255N, R269K, M275V, S283G, R284GA
 PK033PK033KX232623None   E11D, K14R, V31I, V32I, L45Q, T112V, I113V, T124A, T125A, V126F, G134S, I135V, V201I, T206S, K211R, L234I, S255R, S283G, D286NA
 PK027PK027KX232619None   E11D, K14R, R20K, V32I, I60M, I72V, L74I, T112V, I113V, T124A, T125A, V126F, G134S, I135V, D167E, V201I, I203M, T206S, K211R, N222K, Y227F, L234I, D253H, D256E, M275V, S283G, R284GA
 PK026PK026KX232618None  L74MK14R, R20K, V32I, I60M, I72V, I84L, T112V, I113V, T124A, T125A, V126F, G134S, I135V, D167E, V201I, I203M, T206S, K211R, N222K, Y227F, L234I, D253Y, M275V, S283G, R284GA
 PK021PK021KX232614None   K14R, R20K, V32I, M50R, I72V, I84L, G106A, T112V, I113V, T124A, T125A, V126F, G134S, I135V, D167E, G193E, V201I, I203M, T206S, K211R, N222K, L234I, D279G, S283GA
 PK018PK018KX232611None   E11D, R20K, V32I, I72V, I84L, T112V, I113V, T124A, T125A, V126F, I135V, D167E, V201I, T206S, K215N, N222K, L234I, S283G, R284G, D286NA
 PK017PK017KX232610None   K14R, R20K, V32I, I60M, I72V, G82S, I84L, T112V, I113V, T124A, T125A, V126F, I135V, D167E, V201I, A205S, T206S, D207E, N222K, L234I, S283G, R284G, D286NA
 PK016PK016KX232609None   K14R, R20K, V32I, I60M, I72V, I84L, T112V, I113V, T124A, T125A, V126F, I135V, D167E, V201I, A205S, T206S, D207E, N222K, L234I, S283G, R284G, D286NA
 PK015PK015KX232608None   K14R, R20K, V31I, L101I, T112V, T124A, T125A, K136T, G163E, D167E, V201I, T206S, L234I, S283G, D286NA
 PK014PK014KX232607None  T97AA21T, I72V, I84L, T112V, I113V, T124A, T125A, V126F, G134S, I135V, V165I, D167E, V201I, T206S, N222K, L234I, M275V, S283G, R284G, E287AA
 PK012PK012KX232605None   K14R, R20K, A21T, V31I, I72V, L74I, I84L, T112V, I113V, T124A, T125A, V126F, G134S, I135V, D167E, V201I, I203M, T206S, K211R, N222K, Y227F, L234I, D253Y, M275V, S283G, R284GA
 PK004PK004KX232597None   E11D, K14R, R20K, V31I, V32I, I72V, I84L, T112I, I113V, T124A, V126F, I135V, D167E, V201I, A205S, T206S, I208L, N222K, L234I, S283G, R284GA
 PK002PK002KX232595None   K14R, R20K, V31I, S39N, Y83F, T112I, I113V, T124A, T125A, V126F, G134S, I135V, D167E, K173R, V201I, T206S, K215N, N222K, L234I, D279G, S283G, R284GA
 PK001PK001KX232594None   E11D, K14R, R20K, S24N, L101I, T112I, T124A, T125A, I135V, D167E, V201I, T206S, K219N, N222K, L234I, S255N, S283G, R284G, D288NA
Gashnikova (2016)5IN_5KX574446None   D3E, E11D, R20K, V31VI, V32VI, L63LV, I72IV, L74I, T112I, I113V, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, T206S, L234I, S255NA
Gashnikova (2016)Tyumen64Tyumen64KX640239None   D3E, R20K, V31I, S39N, H51HR, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T206S, T218I, L234I, K244R, S255NA
 Tyumen14Tyumen14KX640197None   S24G, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, H171Q, V201I, T206S, L234I, S255NA
Heipertz (2016)NG010499NG010499KX389622None   V31I, L101I, G106A, T112V, T124A, T125A, G134D, D167E, V201I, T206S, D207E, I208L, L234I, S283GA
 NG020382NG020382KX389616None   E11D, H16HR, D25E, V31I, I72V, L74I, T112V, T124A, T125A, V126M, G134D, I135V, K136H, F181L, V201I, T206S, L234I, S283GA
 NG010131NG010131KX389633None  L74MK14R, V31I, K111T, T112V, T124A, T125A, K136Q, D167E, T206S, I208L, L234I, D278G, R284G, D288NA
Bradley-Stewart (2017)WoSSVC_INT57WoSSVC_INT57MF442496None   E11D, K14R, R20K, L101I, T112V, I113V, S119P, T125A, K127R, I135V, G149GE, D167E, G193D, S195T, V201I, T206S, T218I, L234I, R269K, K273Q, D278N, S283G, D286NA
 WoSSVC_INT60WoSSVC_INT60MF442499None   K14R, R20K, M50MR, I72IV, L101I, T112V, I113V, S119P, T122I, T124N, T125A, I135V, D167E, G193D, S195T, V201I, T206S, T218I, L234I, R269K, K273Q, A276AV, D278N, S283G, D286NA
 WoSSVC_INT89WoSSVC_INT89MF442528None   K14R, V32I, I72V, L74X, T112V, I113V, T124A, T125A, V126M, G134N, K136Q, V165VI, V201I, T206S, I220V, L234I, V281M, S283G, D286NA
Rodgers (2017)CG-0086-01VCG-0086-01VKY365208None  T97AV31I, M50I, L74I, L101I, T112V, I113L, T124G, T125A, G134D, T206S, T218S, L234I, S283GA
 CG-0378-02VCG-0378-02VKY392771None   K14R, V31I, I72V, L101I, G106A, S119T, T124A, T125A, G134D, I135V, D167E, V201I, T206S, D207E, L234I, D253E, S255N, S283G, R284G, D286AA
Inzaule (2018)UGJFPPM182UGJFPPM182MG694077None   S17N, V31I, S39N, I60M, I72V, I113V, T124A, T125A, V126F, G134D, I135F, F139Y, D167E, V201I, T206S, K211R, Q221T, S255N, D270H, S283GA
 UGJFPPM072UGJFPPM072MG694063None   K14R, S17N, V31I, I60M, I72V, I84M, K111R, T112V, I113V, S119T, T124A, T125A, K136Q, V201I, T206S, I208L, L234V, D256E, S283GA
 UGJCRPM219UGJCRPM219MG694054None   K14R, V32I, I60M, I72V, T112V, I113V, S119T, T124A, T125A, V126F, K136Q, F139Y, D167E, K173R, V201I, T206S, Q221K, N222K, L234I, S283GA
 UGJCRPM217UGJCRPM217MG694052None  T97AE11D, K14R, S24N, V31I, M50I, I60M, T112V, I113V, S119T, T124A, T125A, V126F, G134S, I135V, K136Q, V201I, T206S, T218S, Y227F, L234I, S255G, S283GA
 UGJCRPM165UGJCRPM165MG694043None   K14R, S39C, M50L, I60M, I72V, T112V, I113V, S119P, T124A, T125A, G134N, K136Q, D167E, V201I, T206S, D207E, M275V, S283GA
 NILUTPM085NILUTPM085MG693883None   K14R, V31I, S39N, M50R, I72V, L74I, T112V, I113V, T124A, T125A, V126M, G134K, K136Q, G163E, V201I, A205S, T206S, L234I, D270E, S283GA
 KEMATPM018KEMATPM018MG693832None   E11D, K14R, N27G, V31I, L101I, T112V, I113V, T124A, T125A, K136Q, V176L, V201I, T206S, L234I, S283GA
 KECRHPM089KECRHPM089MG693804None   S17N, V31I, V32I, L45I, I72V, K111R, I113V, T124A, T125A, V126F, K136Q, V165I, D167E, V201I, T206S, S230N, D279G, S283GA
 KECRHPM085KECRHPM085MG693803None   K14R, S17N, V31I, I72V, K111R, T112V, I113V, T124A, T125A, K136Q, I182V, V201I, T206S, T218L, R224Q, D232E, L234V, S255N, D270N, S283GA
 KECRHPM082KECRHPM082MG693802None   K14R, S17N, V31I, L45Q, I72V, L101I, T112V, I113V, T124A, T125A, K136Q, D167E, K173R, G193D, V201I, T206S, L234I, S255N, R269K, D270H, S283G, D288NA
 KECRHPM032KECRHPM032MG693792None   K14R, V31I, I72V, T112V, I113V, T124N, T125A, D167E, V201I, T206S, K211T, I268L, D270H, S283GA
 KECRHPM022KECRHPM022MG693789None   K14R, A21T, V31I, I60M, I72V, K103R, I113V, S119T, T124A, T125A, V126F, I135V, K136Q, D167E, V201I, T206S, Q216N, L234I, S283G, D288NA
 KECRHPM016KECRHPM016MG693788None   K14R, S24H, V31I, I72V, L74I, I84M, L101V, T112V, S119P, T124A, T125P, I135V, F181L, V201I, T206S, K219N, N222K, L234I, S283GA