<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Integrase Inhibitors

Subtype A
Gene IN
Mutation I203M
Rx II-naive
IncludeMixtures No
References 13
Patients 28
Isolates 28
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# INIs WksINIMajorDRMs INIMinorDRMs OtherMutSubtype
Alizon (1986)MALCGMALMALCGX04415None   V31I, L74I, L101I, T112V, I113V, T124A, T125A, G134N, D167E, V201I, I203M, S230N, L234I, S283G, R284GA
Njai (2006)MP141199CM.1411AM279396None  T97AV31I, L63M, I72V, L74I, T112V, I113L, T124N, T125A, V126M, G134N, K136Q, L158LF, D167E, V201I, I203M, T218S, L234IA
Rodriguez (2006)1579A1579ADQ083238None  L74MV31I, M50I, I72V, P90Q, L101I, T112V, I113V, T124A, T125A, K136Q, D167E, V201I, I203M, K219R, S283GA
Sanders-Buell (2007)AF10405AF104EF158042None   D6E, K14R, V31I, S39N, I60M, I72V, T112I, I113V, T124A, T125A, V126F, K136H, D167E, V201I, I203M, S283GA
Vidal (2009)KS069KS069FM877780None  F121LE11D, S24H, V32I, D41N, M50I, I60V, I72V, L101I, T112I, T124A, G134D, K136Q, D167E, I203M, T218I, L234I, S283GA
Tovanabutra (2010)KECst_006KECst_006FJ623475None   K14R, V31I, V32I, I72T, L74I, T112V, I113V, S119P, T124S, T125A, K136Q, D167E, V201I, I203M, K219N, N222K, S283GA
 KECst_010KECst_010FJ623491None   K14R, V32I, D41N, M50I, I60M, I72V, T112I, T124A, T125A, K136Q, D167E, V201I, I203M, Q216H, Y227F, S255G, S283GA
Jahanbakhsh (2012)KSH29KSH29INTAB716168None   D6E, K14R, A21AT, M22MI, A23V, E35EQ, S39N, M50MI, I60M, I72IV, T112V, I113V, T124S, T125A, V126F, G134S, K136Q, D167EK, V201I, I203M, I208IM, D232DN, L234LH, S283GA
 SYZ40SYZ40INTAB716178None  L74MD6E, K14R, S17N, N27NI, V31I, E35Q, S39N, I60M, I72V, T112I, I113V, T124A, T125A, V126F, G134S, K136Q, D167E, V201I, I203M, S283GA
 THR02THR02INTAB716143None   K14R, E35Q, S39N, I60M, I72V, L74I, G106GA, K111R, T112V, I113V, T124A, T125A, V126F, G134S, K136Q, I141IF, D167EK, I191IM, S195T, V201I, I203M, S283G, R284RGA
 THR07THR07INTAB716148None  L74LIMVD6E, K14R, R20RG, V31I, S39SN, I60M, K71KR, I72V, T112V, I113V, T124A, T125A, V126F, G134S, I135IV, K136Q, D167E, K173R, V201I, I203M, I204IT, S283GA
 THR15THR15INTAB716156None R263RK K14R, L28I, V31I, V32I, K34KR, S39N, I60M, I72V, T112V, I113V, T124A, T125A, V126F, G134GS, K136Q, N144NY, D167E, H171HP, R187RK, V201I, I203M, N222K, R231RK, D232DN, K240R, V259VI, A265AT, S283GA
 KSH24KSH24INTAB716163None   D6E, K14R, P30AS, S39C, I60M, I72V, T112A, I113V, T124A, T125A, V126F, K136Q, D167EK, V201I, I203M, I220V, D232DN, L234I, S283GA
Jahanbakhsh (2013)11IR.KSH24F11IR.KSH24FAB703609None   D6E, K14R, P30A, S39C, I60M, I72V, T112A, I113V, T124A, T125A, V126F, K136Q, D167E, V201I, I203M, I220V, L234I, S283GA
 10IR.THR01F10IR.THR01FAB703607None   K14R, V31I, S39N, I60M, I72V, T112V, I113V, T124A, T125A, V126F, K136Q, D167E, V201I, I203M, S283GA
 11IR.SYZ38F11IR.SYZ38FAB703614None   D6E, K14R, V31I, S39N, I60M, I72V, I84L, T112I, I113V, T124A, T125A, V126F, G134S, K136Q, D167E, V201I, I203M, Q216H, S283GA
 11IR.KSH29F11IR.KSH29FAB703611None   D6E, K14R, A21T, A23V, S39N, D41DN, I60M, T112V, I113V, T124S, T125A, V126F, G134S, K136Q, D167E, V201I, I203M, D232DN, L234LH, S283GA
Reigadas (2013)600600JX425845None   E11D, K14R, A21T, A23V, V31I, M50I, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136Q, D167E, V201I, I203M, L234I, V260I, S283GA
 1812118121JX451890None   E11D, V31I, I72V, T112V, I113V, S119T, T122TI, T124A, T125A, K136Q, V201I, I203M, L234I, D279GA
Billings (2016)KE406723V2KE406723V2KT022365None   K14R, V31I, I60M, T97S, T112V, I113V, T124A, T125A, V126F, K136N, D167E, S195T, V201I, I203M, K211R, T218I, L234I, S255N, I268L, D270H, S283GA
 KE185405V4KE185405V4KT022370None   K14R, V31I, I72V, T112V, I113V, T124A, T125A, K136Q, K160R, D167E, V201I, I203M, S283GA
Billings (2016)CO0439V5CO0439V5KX907347None   E11D, K14R, I72V, L101I, G106A, T112I, T124A, T125A, G134D, K136Q, D167E, I200M, V201I, I203M, I220LA
 CO3083V4CO3083V4KX907364None   E11D, V31I, L45Q, I60M, I72V, A98G, T112V, I113V, T124A, T125A, V126F, K136Q, D167E, V201I, I203M, Q216N, N222T, R224Q, L234I, D270N, S283GA
 CO0329V1CO0329V1KX907342None  T97AE11D, K14R, V31I, V32I, D41N, I60M, T112I, I113V, T124A, T125A, V126F, G134D, I135V, K136Q, D167E, V201I, I203M, I208L, E212A, Q216H, T218I, D232E, L234I, D253H, S283GA
Gashnikova (2016)Tyumen60Tyumen60KX640235None   V31I, I72V, L74I, A91T, T112I, I113V, S119P, T124S, T125A, G134N, K136Q, V201I, I203M, L234IA
 Tyumen04Tyumen04KX640188None  T97AD3E, K14R, R20K, V31I, V32I, L63V, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, I203M, L234I, S255HA
 Tyumen62Tyumen62KX640237None   D3E, E11D, R20K, A21T, V31I, D64DN, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, I203M, T218I, L234I, S255NA
Pandey (2016)NARI-FLS_VB11VB11KT152841None  L74IME10D, V31I, V32I, M50I, I72V, T93S, L101I, T112V, I113V, T124A, T125A, K136Q, V165I, D167E, V201I, I203M, S283GA