Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
CA637 | CA9994 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT | 52 |
2 | DDI | 52 |
3 | 3TC+D4T | 17 |
4 | 3TC+D4T+SQV | 22 |
5 | 3TC+D4T+IDV | 13 |
6 | 3TC+AZT+IDV | 13 |
7 | 3TC+AZT+NFV | 13 |
8 | 3TC+D4T+RTV+SQV | 47 |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
M46MI, I84V, L90M | L10LF | K20KIM, E35D, M36I, N37E, I62V, I64V, H69Y |
>CA9994| codons 1-99 PQITLWQRPFVTIKIGGQLMEALLDTGADDTVLEDIELPGRWKPKIIGGIGGFIKVRQYD QVLVEICGYKAIGTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, M184V, T215Y | K20R, K122E, I135T, T200A, R211K, A272P, I293V, E297K |
>CA9928| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LEL |
References
Author | Title | Citation |
Shulman, NS | Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: Clinical and genotypic predictors of virologic response. | JAIDS, 2000 |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |