Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1446 | CA9992 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | 3TC+DDI | 8 |
| 3 | 3TC+D4T+IDV | 22 |
| 4 | NFV+NVP+SQV | 35 |
| 5 | None | 24 |
| 6 | 3TC+AZT+IDV+RTV | 13 |
| 7 | 3TC+AZT+IDV+SQV | 18 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V | L24I, L33I, L89V | L10I, I13V, E35D, M36I, N37D, R57K, L63P, A71V, I85V, I93L |
| >CA9992| codons 1-99 PQITLWQRPIVTVKIGGQLKEALIDTGADDTVIEDIDLPGRWKPKIIGGIGGFVKVKQYD QIPIEICGHKVIGTVLVGPTPTNVVGRNVLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K20R, V35VI, R83K, E169D, T200A, H208Y, R211K, L228Q, R284K, I293V |
| >CA9926| codons 1-302 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTPDKKHQKEPPFQWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKALTEVVPLTEEAE LE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |