Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1145 | CA9977 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI+ D4T | 39 |
| 2 | IDV+ AZT+ 3TC | 52 |
| 3 | SQV+ RTV+ D4T+ 3TC | 17 |
| 4 | NFV+ NVP+ D4T+ 3TC | 48 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84IV, L90M | V11VI, G73T | L10I, T12A, I15V, L19I, K20I, L63P, I64IV, A71IV, I93L |
| >CA9977| codons 1-99 PQITLWQRPIIAIKVGGQIIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKIITTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219Q | K101PQ, K103KN | T39A, E40F, K43E, V60I, K122E, D123E, I135T, I178M, V179I, Y181X, G196E, E203K, Q207D, H208Y, R211K, H221HY, L228H, A272P, T286A |
| >CA9912| codons 1-293 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAFLEEEGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLPKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII XQYVDDLYVGSDLEIEQHRTKIKELRDYLWKWGFYTPDQKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVI |
References
| Author | Title | Citation |
| Shulman, NS | Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: clinical and genotypic predictors of virologic response. | JAIDS, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |