Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA606 | CA9976 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 209 |
| 2 | DDI | 82 |
| 3 | D4T | 39 |
| 4 | 3TC+AZT | 17 |
| 5 | 3TC+AZT+SQV | 9 |
| 6 | 3TC+AZT+IDV | 57 |
| 7 | 3TC+D4T+RTV+SQV | 40 |
| 8 | 3TC+D4T+EFV+RTV+SQV+Unknown | 13 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | G73S | L10I, K20I, N37D, I62V, L63P, K70R, A71AT, I72IT |
| >CA9976| codons 1-99 PQITLWQRPIVTIKIGGQLIEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHRTTSTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | K103N | K20R, A98S, K122E, A158S, Q197E, L228LH, V245E |
| >CA9911| codons 1-250 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGEHRTKIEELRQHLLRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKD |
References
| Author | Title | Citation |
| Shulman, NS | Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: clinical and genotypic predictors of virologic response. | JAIDS, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |