Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
CA796 | CA9973 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT | 104 |
2 | AZT+DDI | 266 |
3 | 3TC+D4T+SQV | 39 |
4 | D4T+DDC+NFV | 17 |
5 | 3TC+AZT+IDV+NVP | 17 |
6 | 3TC+AZT+IDV | 10 |
7 | 3TC+AZT+RTV+SQV | 28 |
8 | 3TC+AZT+EFV+Unknown | 5 |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
M46I, L90M | F53FL, G73S | L10I, N37D, D60DE, L63P, A71V, V77I, I93IL |
>CA9973| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGLIKVRQYE QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, D67N, T69D, K70R, M184V, T215F | V75M, K219W | K103N, Y181C | V108I | K20KR, V35T, V60I, I94IL, K122E, I135T, V179VI, H208Y, D218E, L228H, V245E, E248Q |
>CA9908| codons 1-264 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLMDFRELNKRTQDFWEVQLGLPHPAGLKKNKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYVDDLYVGSDLEIGQHRTKIEELRQYLLRWGFFTPEWKHQKEPPFHWMGYELHPDKWT VQPIELPQKDSWTVNDIQKLVGKL |
References
Author | Title | Citation |
Shulman, NS | Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: Clinical and genotypic predictors of virologic response. | JAIDS, 2000 |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |