Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4153 | CA9970 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 56 |
| 2 | AZT+DDI | 31 |
| 3 | 3TC+AZT+RTV | 52 |
| 4 | 3TC+AZT+NFV+NVP | 21 |
| 5 | 3TC+AZT+NFV | 52 |
| 6 | 3TC+D4T+EFV+NFV | 26 |
| 7 | 3TC+D4T+IDV+RTV | 15 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, L90M | N88D | L10I, I13V, E35D, M36I, R41K, L63P, H69Y, A71T, I72T, Q92K |
| >CA9970| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADNTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGYKTTGTVLVGPTPVNIIGRDLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | L100I, K103N | M16MV, E44D, V118I, K122E, Q174R, D177E, G196E, Q207E, R211K, V245K, A272P, K277R, I293V |
| >CA9906| codons 1-303 PISPIETVPVKLKPGVDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPEIVI YQYVDDLYVGSDLEIEQHRTKIEELREHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |