Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4142 | CA9956 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | NRTI | NA |
| 3 | D4T | 21 |
| 4 | 3TC+ D4T+ SQV | 65 |
| 5 | 3TC+ D4T+ RTV | 65 |
| 6 | 3TC+ D4T+ RTV+ SQV | 12 |
| 7 | AZT+ DDI+ NVP+ NFV | 17 |
| 8 | D4T+ DDI+ NVP+ NFV | 34 |
| 9 | 3TC+ ABC+ D4T+ EFV | 7 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10I, R41K, K55R, L63P, I64IV |
| >CA9956| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFVRVRQYD QIPVEICGHKAIGTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y115F, Q151M, M184V, T215Y | F77L, F116Y | Y181C, G190S | T58N, S68G, K101Q, I142V, T200A, I202V, F214L, I293V, E297K |
| >CA9892| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNNPV FAIKKKDGTKWRKLVDLRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAFYSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVSSDLEIGQHRAKVEELRQHLLRWGLYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |