Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4159 | CA9921 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 13 |
| 2 | 3TC+D4T+NFV | 98 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, Q151M, M184V | V75A | S68SG, D121H, K122E, K173Q, D177E, I178L, G196E, T200A, F214FL, T215X, V245M, E248D, D250A, A272P, E291D, I293V |
| >CA9921| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLADFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRQQNPELVI YQYVDDLYVGSDLEIEQHRAKIEELRQHLLRWGLXTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPDKASWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVVPLTEEAE LE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | Q2QH, I13V, L19I, K20I, E35N, M36I, N37D, D60E, Q61E, L63P, A71V, I72T |
| >CA9986| codons 1-99 PHITLWQRPLVTVKIGGQIIEALLDTGADNTVLENIDLPGRWKPKMIGGIGGFIKVRQYE EIPIEICGHKVTGTVLVGPTPVNIIGRDLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |