Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4127 | CA9838 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T | 69 |
| 2 | 3TC+D4T+IDV | 61 |
| 3 | 3TC+D4T+NFV+NVP | 31 |
| 4 | 3TC+D4T+NFV+RTV+SQV | 62 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | F53L, G73GS | L10I, I13V, I15V, K20I, N37T, K55R, L63P, A71I |
| >CA9838| codons 1-99 PQITLWQRPIVTVKVGGQLIEALLDTGADDTVLEEMTLPGRWKPKIIGGIGGLIRVRQYD QIPIEICGHKIISTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V75T | A62V | K103N, Y181C | V35I, A98S, D123E, Q174R, I178L, V179I, Q207E, R211K, T240TA, V245Q, I293V, E297V |
| >CA9436| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLTDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDLII CQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWA VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTVEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |