Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1480 | CA9765 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | 3TC+ AZT | 24 |
| 3 | AZT+ 3TC+ IDV | 14 |
| 4 | AZT+ 3TC+ SQV | 57 |
| 5 | DDI+ NVP+ NFV | 23 |
| 6 | D4T+ DDI+ RTV+ SQV | 32 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | F53FL, Q58E, T74P | L10I, K20M, E35ED, M36I, R41K, K55R, I62V, L63A, A71V, I93L |
| >CA9765| codons 1-99 PQITLWQRPIVTIKIGGQLMEALLDTGADDTVLEDINLPGKWKPKIIGGIGGLIRVREYD QVAIEICGHKVIGPVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | Y181C | V21I, K101X, K122KE, I178M, R211K, L228R |
| >CA9331| codons 1-250 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLXKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQPIVLPEKD |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |