Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4050 | CA9749 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 56 |
| 2 | DDI | 134 |
| 3 | D4T | 26 |
| 4 | 3TC+AZT | 13 |
| 5 | 3TC+D4T+IDV | 39 |
| 6 | D4T+DDI+RTV+SQV | 30 |
| 7 | 3TC+AZT+NFV+SQV | 56 |
| 8 | ABC+AZT+EFV+NFV | 32 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A, L90M | F53L | R41K, L63P, A71V, T74S, V77I, I93L |
| >CA9749| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIVGIGGLVKVRQYD QIPIEICGHKVIGSVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Y115F, Q151M | V75I, F77L, F116Y, K219KE | K103N, Y181C | K238T | K20R, V35M, S68G, R83K, K122E, D123E, R172RK, G196K, T200A, H221Y, V245E, S251N, V292I, I293V, E297K |
| >CA9313| codons 1-302 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKRKDGTRWRKLIDLRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAFYSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFKKQNPDIVI CQYMDDLYVGSDLEIKQHRAKIEELRQHLLRWGFTTPDEKYQKEPPFLWMGYELHPDTWT VQPIELPEKDNWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEIVPLTKEAE LE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |