Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4035 | CA9748 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 28 |
| 2 | AZT+DDI | 14 |
| 3 | 3TC+AZT | 9 |
| 4 | 3TC+AZT+RTV | 35 |
| 5 | 3TC+D4T | 49 |
| 6 | 3TC+D4T+NFV | 42 |
| 7 | Unknown | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | L10I, E35D, M36V, N37Y, R41K, I62V, L63T, A71V, I72V, I93L |
| >CA9748| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADNTVLEDVYLPGKWKPKMIGGIGGFIKVRQYD QVTIEICGHKVVGTVLVGPTPVNIIGRDLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V, T215Y | L100LI, K103N | K20R, A98AS, K101R, K122E, I135IT, I142IT, K173Q, Q174K, D177E, T200TA, Q207E, R211K |
| >CA9298| codons 1-252 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGIRKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRQKNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSW |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |