Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4042 | CA9746 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 104 |
| 2 | D4T | 104 |
| 3 | 3TC+ AZT+ RTV+ SQV | 52 |
| 4 | 3TC+ AZT+ EFV+ RTV+ SQV | 52 |
| 5 | 3TC+ D4T+ IDV+ NVP | 62 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I84V, L90M | E34EQ, N37S, I62V, L63P, V77I, I93L |
| >CA9746| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLQEMSLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | G190S | A98AG | K20KR, T27S, K43E, K101X, V118I, K122E, S162C, E169D, I178L, M184X, R211K, L228H |
| >CA9305| codons 1-234 PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLXKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPDLVI YQYXDDLYVSSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFHWMGYEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |