Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3937 | CA9709 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 35 |
| 2 | 3TC+AZT | 9 |
| 3 | 3TC+AZT+SQV | 4 |
| 4 | 3TC+AZT+RTV | 65 |
| 5 | DDI+NFV+NVP | 91 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82IM, L90M | K43T | I15IV, K20R, E35D, M36I, L63P, I64V, T74TS, I93L |
| >CA9709| codons 1-99 PQITLWQRPLVTIKVGGQLREALLDTGADDTILEDINLPGRWTPKIIGGIGGFVKVRQYD QIPVEICGHKAIGSVLVGPTPINIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, M184V, L210LW, T215Y | K101E, Y181C, G190A | V21I, T27X, K43KR, V60I, K122P, I135T, E138A, I142IV, S162C, Q207E, H221HY, L228LR, A272P, K277KR, T286A, E297K | M41MI |
| >CA9147| codons 1-303 PISPIETVPVKLKPGMDGPKIKQWPLXEEKIKALVEICTEIEREGKISKIGPENPYNTPI FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSTNNATPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRTKIEELREHLWRWGFYTPDKKYQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |