<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA3935 CA9708 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 D4T 38
2 D4T+RTV+SQV 31
3 3TC+D4T+IDV 126

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82F, L90M G73S L10I, A22AV, L63P, A71V, V77I, I93L  
>CA9708| codons 1-99
PQITLWQRPIVTIKIGGQLKEVLLDTGADDTVLEEMNLPGRWKPKMIGGIGGFVKVRQYD
QIPIEICGHKVISTVLIGPTPFNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, M184V, L210W, T215Y K219Q     K20R, V21VI, T39A, E44D, V60I, K103R, V118I, K122E, I132IV, I135T, K173R, Q174K, N175Y, G196E, H208Y, R211K, D218E, A272P, I293V, A304G  
>CA9143| codons 1-304
PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPI
FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSIPL
DEDFRKYTAFTVPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKYPDIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELG

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005