Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1813 | CA9691 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 112 |
| 2 | AZT+ 3TC | 56 |
| 3 | 3TC+ D4T+ IDV | 34 |
| 4 | IDV+ DDI+ DLV+ 3TC | 29 |
| 5 | SQV+ RTV+ DDI+ 3TC | 35 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, N88S, L90M | L10V, I13V, I15V, K20M, E35D, M36I, I62V, L63P, A71T, I93L |
| >CA9691| codons 1-99 PQITLWQRPVVTVKVGGQLMEALLDTGADDTVLEDINLPGRWKPKLIGGIGGFIKVRQYD QVPIEICGHKTIGTVLVGPTPVNIIGRSLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, V75M, M184V, L210W, T215Y | K219Q | K103N | V60I, K102KR, V118I, K122KE, I135T, H208Y, R211K, F214L, D218E, L228H, R284K, T286A, I293V, E297K |
| >CA9124| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKRNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGLYTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKALTEVVPLTKEAE LEL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |