Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1437 | CA9688 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 95 |
| 2 | 3TC+AZT | 74 |
| 3 | 3TC+AZT+IDV | 15 |
| 4 | 3TC+DDI+IDV | 17 |
| 5 | D4T+DDC+SQV | 18 |
| 6 | D4T+DDI+SQV | 5 |
| 7 | 3TC+DDI+SQV | 32 |
| 8 | Unknown | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V | L10I, K20KR, E35D, M36I, I62V, L63P, A71T, V77I, I93L |
| >CA9688| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLIGPTPVNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184MV, T215F | K219Q | L100LI, Y188L | V35VL, T39E, R83K, K173KE, I178L, Q207E, A272P, K277R, T286A, E297K |
| >CA9114| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICEEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKKTQDFWEVQLGIPHPAGIKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPDLVI YQYVDDLLVGSDLEIGQHRTKIEELREHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE LEL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |