Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4034 | CA9684 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | 3TC+SQV | 13 |
| 3 | DDC | 4 |
| 4 | IDV | 17 |
| 5 | RTV | 8 |
| 6 | RTV+SQV | 30 |
| 7 | DLV+IDV | 17 |
| 8 | NVP+IDV | 12 |
| 9 | 3TC+D4T+DDI+NFV | 30 |
| 10 | DDI+NFV | 12 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84IV, L90M | L10F, L33I, G73S | E35D, M36I, P39Q, I62V, L63P, A71V, V82I |
| >CA9684| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVIEDINLQGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLVGPTPINVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | K103N | T39A, V118I, K122E, Q207K, F214L, L228H |
| >CA9297| codons 1-243 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRKHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQP |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |