Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3870 | CA9651 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NNRTI | NA |
| 2 | 3TC+D4T+SQV | 52 |
| 3 | Unknown | 52 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L90M | G73T | L10I, L19I, N37T, D60E, L63P, I64V, A71V, V77I, I93L |
| >CA9651| codons 1-99 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVLEEMTLPGRWKPKMIGGIGGFVKVRQYE QIPVEICGHKVITTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | K103KN, V106VA, Y181C, G190A | A98G, F227L | E6K, M16V, T39A, K43Q, E44D, L109I, V118I, K122E, S162X, G196E, T200I, E203K, Q207E, H208Y, R211K, H221Y |
| >CA9046| codons 1-264 PISPIKTVPVKLKPGVDGPKVKQWPLTEEKIKALVEICAELEQDGKISKIGPENPYNTPV FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPGGLKKNKSATVIDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQXSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIEQHRIKIKELREYLWKWGFYTPDKKYQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |