<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA3871 CA9643 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDI 13
2 AZT+DDC 92
3 3TC+AZT+SQV 16
4 3TC+D4T+IDV 142

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54A, V82F   L10I, I13V, K14R, I15V, K20M, M36V, N37T, I62V, I64V, A71V, L89I  
>CA9643| codons 1-99
PQITLWQRPIVTVRVGGQLMEALLDTGADDTVLEEVTLPGRWKPKMIGGIGGFAKVRQYD
QVLVEICGHKVIGTVLVGPTPFNIIGRNILTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y K219R M230ML V108I V35I, K43Q, E44D, V60I, V118I, K122E, D123N, I135M, G196E, I202IT, E203ED, H208Y, R211KN, H221Y, A272P D218DH, G273GRW, Q278QP, A299AG
>CA9047| codons 1-303
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPI
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPL
DENFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKTDELRQYLWNWGFYTPHRKYQKEPPFLWLGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPWIKVKPLCKLLRGTKALTEVIPLTEEGE
LEL

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005