Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3891 | CA9641 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 156 |
| 2 | DDI | 60 |
| 3 | D4T | 26 |
| 4 | AZT | 8 |
| 5 | 3TC+D4T | 17 |
| 6 | 3TC+AZT+RTV | 13 |
| 7 | 3TC+AZT+IDV | 35 |
| 8 | 3TC+D4T+IDV | 25 |
| 9 | D4T+DDC+NFV | 52 |
| 10 | ABC+EFV+RTV | 27 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, V11VA, I15V, K20R, E35D, M36I, N37D, L63T, I72V |
| >CA9641| codons 1-99 PQITLWQRPVATIKVGGQLREALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | I135T, R211K, V245K | L234LH |
| >CA9083| codons 1-261 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYEHHPDKWT VQPIKLPEKDSWTVNDIQKLV |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |