Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3999 | CA9598 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 130 |
| 2 | AZT+DDC | 57 |
| 3 | DDC+DDI | 74 |
| 4 | AZT+DDC | 30 |
| 5 | 3TC | 87 |
| 6 | 3TC+IDV | 35 |
| 7 | 3TC+D4T+IDV | 43 |
| 8 | 3TC+D4T+DLV+IDV | 18 |
| 9 | 3TC+D4T+RTV+SQV | 50 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73S | L10I, N37D, I62V, L63P, A71V, I72M, V77I, I93L |
| >CA9598| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGHKVMSTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K103N | K43N, E44D, A98S, V118I, K122E, I135V, E138Q, S162C, G196E, E203K, Q207E, H208Y, R211K |
| >CA9256| codons 1-221 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNQTPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIKELREYLWKWGFYTPDKKH |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |