Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4075 | CA9597 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 65 |
| 2 | D4T | 43 |
| 3 | D4T+3TC+IDV | 112 |
| 4 | D4T+DDI+NVP | 42 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I | L10F, N88T | I15V, K20T, M36MI, L63P, A71T |
| >CA9597| codons 1-99 PQITLWQRPFVTIKVGGQLTEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKTIGTVLVGPTPVNIIGRTLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | V21I, V35M, K43N, E44D, V106I, V118I, K122E, D123E, I135T, I178M, Q197I, H208Y, R211K |
| >CA9355| codons 1-244 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALMEICTELENDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGIHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPI |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |