<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA794 CA9584 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 78
2 DDI 43
3 DDC 13
4 D4T 30
5 AZT+D4T 18
6 3TC+AZT+IDV 52
7 D4T+DDI+NVP 19
8 3TC+D4T+RTV+SQV 58
9 3TC+DDI+EFV+RTV+SQV 17
10 3TC+RTV+SQV 21

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, I84V, L90M K43T L10I, E35D, M36V, D60E, I62V, L63P, A71V  
>CA9584| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDVNLPGRWTPKLIGGIGGFVKVRQYE
QVPIEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K65R, D67N, Q151M, L210W, T215Y A62V, V75I, F116Y L100I, Y181I V179D M16V, K20R, V21I, V35I, K43Q, S68N, E79D, R83K, K122E, K166KR, I167V, G196E, Q197K, D218E K154K*
>CA9253| codons 1-222
PISPIETVPVKLKPGVDGPRIKQWPLTEEKIKALIEICTELEQEGKISKIGPENPYNTPV
FVIKRKNNTKWRKLIDFRDLNKKTQDFWEVQLGIPHPAGIKKKKSVTVLDVGDAYYSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGW*GSPAIFQSSMTRVLEPFRKQNPDIDI
IQYMDDLYVGSDLEIEKHRTKIEELRQHLWRWGFYTPEKKHQ

References
Author Title Citation
Shulman, NS Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: Clinical and genotypic predictors of virologic response. JAIDS, 2000
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005