Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1271 | CA9580 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | DDI | 52 |
| 3 | D4T | 100 |
| 4 | 3TC+AZT | 35 |
| 5 | 3TC+AZT+IDV | 22 |
| 6 | 3TC+D4T+IDV | 13 |
| 7 | 3TC+D4T+IDV+NVP | 4 |
| 8 | 3TC+RTV+SQV | 77 |
| 9 | 3TC+DDI+EFV+RTV+SQV+Unknown | 27 |
| 10 | DDI+EFV+Unknown | 1 |
| 11 | None | 5 |
| 12 | 3TC+RTV+SQV | 10 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, L90M | F53FL, L89LV | L10I, K20R, E35D, M36I, N37E, R41K, L63P, K70KT, A71AV, G73X, V77I, I93L |
| >CA9580| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTILEDIELPGKWKPKIVGGIGGLIKVRQYD QIPIEICGHTVIXTVLIGPTPVNIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | V75L, K219N | K103N | V108I | K20R, T39A, E44D, V118I, K122E, I135T, D177E, H208Y, R211N |
| >CA9345| codons 1-262 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWNWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVG |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |