Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2100 | CA9577 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 46 |
| 2 | DDC | 53 |
| 3 | D4T | 91 |
| 4 | 3TC+D4T+IDV | 52 |
| 5 | DLV+AZT+NFV+SQV | NA |
| 6 | Unknown | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, L90M | K20R, E35D, M36I, Q61E, I62V, L63P, I66F, A71T, I72T |
| >CA9577| codons 1-99 PQITLWQRPLVTIKIGGQLREALLDTGADDTILEDINLPGRWKPKMIGGIGGFIKVRQYD EVPIEFCGHKTTGTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, T215Y | D67G, K219KN | L100I, M230L | V179D | V35I, K103R, K122E, I202V, R211K, T240K, V276VI, I329V, Q334E, A371V, K390R, K395R, E399D, A400S, S468P |
| >CA9235| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKGSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKKRKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIDI YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGFYTPDNKHQKEPPFLWLGYELHPDKWK VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKIKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGEGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQRETWDSWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPLTDTTNQKTELQ AIHLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |