Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3983 | CA9562 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 83 |
| 2 | D4T | 39 |
| 3 | D4T+SQV | 13 |
| 4 | 3TC+D4T+IDV | 65 |
| 5 | 3TC+D4T+NFV | 80 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30DN, L90M | N88D | R41K, K43R, K45R, L63P, A71V, I72V, V77I, I85IV, Q92K |
| >CA9562| codons 11-99 VTIKIGGQLKEALLDTGADNTVLEEMNLPGKWRPRMIGGIGGFIKVRQYDQIPIEICGHK VVGTVLIGPTPVNIVGRDLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, T215Y | K219Q | S3SC, V35L, T39A, V60I, K122E, I135T, I167IV, D177DN, I178M, G196E, E203K, Q207E, H208Y, W212LM, D218DE, K223E, L228H, V245K, E248EV | L234LV |
| >CA9232| codons 1-252 PICPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKVLEPFRKQNPNMVI YQYVDDLYVGSDLEIEQHRTKIKELREYLLRLGFYTPEQKHQEEPPFHWMGYEVHPDKWT VQPIKLPVKDSW |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |