Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3985 | CA9560 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 78 |
| 2 | AZT+DDC | 86 |
| 3 | 3TC+AZT | 30 |
| 4 | 3TC+AZT+SQV | 13 |
| 5 | 3TC+D4T+RTV | 17 |
| 6 | D4T+DDI+IDV | 26 |
| 7 | AZT+DDI+NFV | 17 |
| 8 | NVP+AZT+DDI+NFV | 13 |
| 9 | DDI+RTV+SQV | 30 |
| 10 | D4T+DDI+RTV+SQV | 13 |
| 11 | D4T+DDI+NFV+SQV | 18 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V | L24I | L10I, A22V, N37S, K55R, R57K, D60E, Q61E, I62V, L63P, A71V, V77I, I93L |
| >CA9560| codons 1-99 PQITLWQRPIVTIKIGGQLKEVLIDTGADDTVLEEMSLPGRWKPKIIGGIGGFIRVKQYE EVPIEICGHKVIGTVLIGPTPVNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | D67E | K103KN | K32N, K49KR, S68G, R211K |
| >CA9234| codons 1-227 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTELEKEGKISRIGPENPYNTPV FAIKKKEGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |