<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA3985 CA9560 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 78
2 AZT+DDC 86
3 3TC+AZT 30
4 3TC+AZT+SQV 13
5 3TC+D4T+RTV 17
6 D4T+DDI+IDV 26
7 AZT+DDI+NFV 17
8 NVP+AZT+DDI+NFV 13
9 DDI+RTV+SQV 30
10 D4T+DDI+RTV+SQV 13
11 D4T+DDI+NFV+SQV 18

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V L24I L10I, A22V, N37S, K55R, R57K, D60E, Q61E, I62V, L63P, A71V, V77I, I93L  
>CA9560| codons 1-99
PQITLWQRPIVTIKIGGQLKEVLIDTGADDTVLEEMSLPGRWKPKIIGGIGGFIRVKQYE
EVPIEICGHKVIGTVLIGPTPVNVIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L210W, T215Y D67E K103KN   K32N, K49KR, S68G, R211K  
>CA9234| codons 1-227
PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTELEKEGKISRIGPENPYNTPV
FAIKKKEGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPF

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005