Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3977 | CA9548 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 43 |
| 2 | AZT+ 3TC | 39 |
| 3 | AZT+ 3TC+ IDV | 22 |
| 4 | D4T+ 3TC+ SQV | 23 |
| 5 | DDI+ 3TC+ RTV | 25 |
| 6 | None | 20 |
| 7 | D4T+ NVP+ NFV | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I84V | L10V, I15V, G16E, E34N, E35D, N37S, P39PS, R41K, L63T, I72V, V77I |
| >CA9548| codons 1-99 PQITLWQRPVVTIKVEGQLKEALLDTGADDTILNDMSLSGKWKPKIIGGIGGFIKVRQYD QITIEICGHKAVGTVLIGPTPVNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K103KN, V106VA, Y181YC | A98G | K20R, V35I, K43N, E44ED, D123E, E203D, H208Y, R211K, A272P, K277R, I293V, E297R |
| >CA9224| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELENDGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSATVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIDELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |