Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3955 | CA9513 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 67 |
| 2 | AZT+DDI | 59 |
| 3 | None | 68 |
| 4 | 3TC+D4T+IDV | 54 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82T | K20I, L63C, A71AV, V77I |
| >CA9513| codons 1-99 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QICIEICGHKVIGTVLIGPTPTNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V | V35M, T39A, T139M, A158S, I178IM | L168*S |
| >CA9186| codons 1-203 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPSIFQSSMTKISEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRTKIE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Kantor, R | Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. | AAC, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |