Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1485 | CA95095 | U.S. | 2007 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 74 |
| 2 | D4T+DDC | 31 |
| 3 | 3TC+AZT | 9 |
| 4 | 3TC+AZT+IDV | 31 |
| 5 | AZT+DDI+IDV | 22 |
| 6 | 3TC+DDI+NFV | 17 |
| 7 | None | 61 |
| 8 | D4T+DDI+SQV | 22 |
| 9 | AZT+EFV+SQV | 48 |
| 10 | ABC+AZT+EFV+SQV | 165 |
| 11 | 3TC+ABC+TDF | 17 |
| 12 | 3TC+ABC+ATV+DDI+RTV+TDF | 96 |
| 13 | 3TC+ABC+ATV+RTV+TDF | 125 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69DN, K70R, T215F | K219Q | K20R, V35M, T39A, E40ED, V60VI, A98S, K104N, I135T, S162Y, G196GE, E203EK, R211Q, L228H, V245E, T286A, V292I, E297K |
| >CA95095| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKNSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIKELRQHLLQWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEIIPLTKEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, K14R, L63X, I72V, V77I, I93L |
| >CA95094| codons 1-99 PQITLWQRPIVTIRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIXIEICGHKAVGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |