Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3945 | CA9495 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 25 |
| 2 | DDI | 21 |
| 3 | 3TC+D4T | 13 |
| 4 | 3TC+D4T+IDV | 8 |
| 5 | AZT+DDI+NFV | 91 |
| 6 | RTV+SQV | 30 |
| 7 | EFV+SQV | 7 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | G48GW, F53FL | L10V, K20R, E35D, M36I, N37E, R57K, L63P, A71V, I93L |
| >CA9495| codons 1-99 PQITLWQRPVVTIKIGGQLREALLDTGADDTVLEDIELPGRWKPKMIWGIGGLVKVKQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W | T215C | Y188L | K43E, K101Q, V118I, D123E, S162C, T200A, R211K, L228H, I270IV, A272P, V292I, E297K |
| >CA9165| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRAKIEELRQHLWKWGFCTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQVYPGIKVKQLCKLLRGTKALTEIIPLTKEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |